Vitamin K-2: Functions, Sources, Benefits, And Deficiency Symptoms

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Medical News TodaySubscribeWhat to know about vitamin K-2

Medically reviewed by Jared Meacham, PhD., RD, CSCS — Written by Jamie Eske — Updated on November 22, 2023

What is it?
Functions
K-1 vs. K-2
Dietary sources
Health benefits
Daily intake
Deficiency symptoms
Supplements
Summary

Vitamin K is an essential vitamin that occurs in two forms, K-1 and K-2. Dietary sources of vitamin K-2 include animal proteins and fermented foods. The bacteria in the human gut also produce small quantities of vitamin K-2.

Vitamin K helps boost heart and bone health, and may help manage blood sugar and prevent depression, anxiety, and cancer. Vitamin K-1 is the primary form, and it mainly comes from leafy green vegetables.

In this article, we discuss vitamin K-2, its functions, and how it differs from K-1. We also describe dietary sources, health benefits, the recommended daily intake, deficiency symptoms, and supplements.

What is it?

a bowl of sauerkraut — Juan Moyano/Stocksy United

Vitamin K refers to a family of fat-soluble vitamins that the body needs to produce a protein called prothrombin, which promotes blood clotting and regulates bone metabolism.

The vitamin comes in two main forms:

Vitamin K-1, or phylloquinone, occurs naturally in dark leafy green vegetables and is the main dietary source of vitamin K.
Vitamin K-2, or menaquinone, is present in small quantities in organ meats and fermented foods. Gut bacteria also produce vitamin K-2.

Functions

The body needs both types of vitamin K to produce prothrombin, a protein that plays crucial roles in blood clotting, bone metabolism, and heart health. Vitamin K also helps facilitate energy production in the mitochondria of cells.

Vitamin K-1 is primarily involved in blood coagulation. K-2 may have a more diverse range of functions in the body.

In a long-term study involving 36,629 participants, researchers observed an association

between high intakes of vitamin K-2 and a reduced risk of developing peripheral arterial disease (PAD), particularly in people with high blood pressure. However, the authors concluded that K-1 had no effect on PAD risk.

Vitamin K has antioxidant properties. It protects cellular membranes from damage due to excess free radicals, in a process known as peroxidation. Blood thinning medication, such as warfarin, can lower the antioxidative potential of vitamin K.

K-1 vs. K-2

Vitamins K-1 and K-2 have different chemical structures. Both types have a phytyl side chain, but K-2 also has isoprenoid side chains.

K-2 has several subtypes, called menaquinones (MKs), which scientists have numbered MK-4 through MK-13, based on the length of their side chains.

K-1 is the primary form of the vitamin, and it is mainly present in leafy green vegetables. However, the body has difficulty absorbing vitamin K-1 from plants.

According to a 2019 review, research suggests that the body absorbs 10 times more vitamin K-2, in the form of MK-7, than vitamin K-1.

Vitamin K is fat-soluble, so eating dietary fats, such as butter or plant oils, may enhance the body’s absorption of vitamin K-1 from plants.

Bacteria in the gut can synthesize vitamin K-1 into vitamin K-2. Also, fermented foods, meat, and dairy products contain modest amounts of vitamin K-2.

The body stores vitamins K-1 and K-2 differently. K-1 accumulates in the liver, heart, and pancreas. K-2 occurs in high concentrations in the brain and kidneys.

Best dietary sources

Several foods are rich in vitamin K-1, and vitamin K-2 is much less common. Bacteria in the gut can convert some K-1 into K-2.

Fermented foods are a good source of vitamin K-2.

Also, because it is fat-soluble, organ meats and high-fat dairy products contain fairly substantial quantities of vitamin K-2. Conversely, lean meats, such as poultry, are not good sources of K-2.

Dietary sources of vitamin K-1 include:

dark leafy green vegetables, such as spinach, kale, and collards
lettuce
turnips
broccoli
carrots
vegetable oils
blueberries
grapes

Dietary sources of vitamin K-2 include:

natto, a traditional Japanese dish of fermented soybeans
sauerkraut
dairy products, especially hard cheeses
liver and other organ meats
beef
pork
egg yolks
chicken
fatty fish, such as salmon

Health benefits of vitamin K-2

In addition to its crucial role in blood clotting and wound healing, vitamin K-2 has a number of other health benefits. We discuss some of these below.

Heart health

Vitamin K-2 may lower the risk of cardiovascular damage and improve overall heart health.

According to a 2015 review article, K-2 activates a protein that prevents calcium deposits from forming in the walls of blood vessels. The author cited findings suggesting that a diet high in natural vitamin K2 may decrease the risk of coronary heart disease.

Bone health

Vitamin K-2 promotes healthy bone mineral density by carboxylating osteocalcin, a protein that binds calcium to bones.

A 2019 study investigated the effects of taking MK-4 supplements in 29 postmenopausal females who had experienced hip or vertebral compression fractures.

The researchers concluded that taking 5 milligrams of an MK-4 supplement daily reduced the levels of undercarboxylated osteocalcin to that “typical of healthy, premenopausal women.”

A 2017 study from Japan examined whether vitamin K-2 enhances the effects of standard medication for osteoporosis in adult females aged 65 or older. According to the results, vitamin K-2 did not appear to enhance the effects of the osteoporosis medication.

Anxiety and depression

High blood glucose levels may increase a person’s risk of developing depression, anxiety, and cognitive impairment.

A 2016 study investigated the effects of vitamin K-2 in rats with metabolic syndrome, high blood glucose levels and symptoms of anxiety, depression, and memory deficit.

After 10 weeks, treatment with vitamin K had normalized blood glucose and reduced symptoms of anxiety and depression. However, it did not improve memory deficit in the rats.

Cancer

Vitamin K-2 has antioxidant properties that may help protect against cancer. In addition, findings suggest that K-2 may suppress genetic processes that lead to tumor growth.

According to a 2018 study, vitamin K-2 that scientists had modified with a sialic acid-cholesterol conjugate significantly suppressed tumor growth in mouse cells.

A 2019 study suggests that K-2 significantly reduces the activity of hypoxia-inducible factor 1-alpha (HIF-1A) in hepatocellular carcinoma cells. HIF-1A is an important target for cancer drug therapy.

Recommend daily intake

The Office of Dietary Supplements (ODS) recommend a daily intake of 120 micrograms (mcg) of vitamin K for adult males and 90 mcg for adult females. There is no specific recommendation for vitamin K-2.

Deficiency symptoms

According to the ODS, vitamin K deficiency affects very few adults in the United States. Newborns and people with certain gastrointestinal disorders, such as celiac disease and ulcerative colitis, have a higher risk of vitamin K deficiency.

A severe deficiency increases the time it takes for the blood to clot, making a person more prone to bruising and bleeding and increasing the risk of hemorrhage.

A deficiency of the vitamin can also reduce bone mineralization, which can lead to osteoporosis.

Certain medications can affect vitamin K levels in the body. For example, long courses of antibiotics can kill the gut bacteria that produce vitamin K. Some cholesterol-lowering medications can also interfere with the body’s ability to absorb vitamin K.

Blood thinners, such as warfarin, can interact dangerously with the vitamin. It is important for people taking these medications to consume the same amount of dietary vitamin K each day and to speak to a doctor before taking supplements or making dietary changes.

Supplements

While the ODS report that vitamin K deficiency is very rare and that most people are getting enough of the vitamin from their diet, anyone at risk of a deficiency may wish to consider dietary supplements.

Many multivitamins contain both forms of vitamin K. A person can also purchase vitamin K as a standalone supplement or in combination with specific nutrients, such as vitamin D, calcium, or magnesium.

The types of vitamin K commonly available in dietary supplements include:

vitamin K-1, as either phylloquinone or a synthetic form called phytonadione
vitamin K-2, as either MK-4 or MK-7

The concentrations of K-1 and K-2 vary, depending on the supplement. Always check the nutrition label before purchasing supplements.

Vitamin K can interact with some drugs, especially blood thinners, so it is important for people taking prescription medications to speak to their doctor before using a dietary supplement.

A variety of vitamin K supplements are available to purchase online.

Summary

There are two main forms of vitamin K: vitamin K-1 and vitamin K-2.

K-1 primarily occurs in leafy green vegetables, and it is the main dietary source of vitamin K. However, the body absorbs K-2 more readily, particularly the K-2 subtype MK-7.

Good sources of vitamin K-2 include fermented foods, organ meats, and dairy products. Fermented soybeans, such as natto, are an especially rich source of vitamin K-2. Bacteria that live in the human gut also produce small quantities of K-2.

Both forms of vitamin K are essential for blood clotting and bone health. However, vitamin K-2 may also protect against certain forms of cancer and heart disease.

Vitamin K deficiency is very rare and most people get enough of this vitamin from their diet. Some gastrointestinal conditions can increase the risk of a deficiency. However, people with these conditions should speak to their doctor before taking a dietary supplement.

People currently taking blood thinners, such as warfarin, should not take vitamin K supplements without seeking medical advice first. Sudden changes in vitamin K levels can impact the anticoagulant effects of warfarin and lead to dangerous complications.

Bones / Orthopedics
Cardiovascular / Cardiology
Nutrition / Diet
Complementary Medicine / Alternative Medicine

How we reviewed this article:

SourcesMedical News Today has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical journals and associations. We only use quality, credible sources to ensure content accuracy and integrity. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.

Gancheva, S. M., & Zhelyazkova-Savova, M. D. (2016). Vitamin K2 improves anxiety and depression but not cognition in rats with metabolic syndrome: A role of blood glucose?https://pubmed.ncbi.nlm.nih.gov/28068285/
Giri, T. K., et al. (2019). Maximal dose-response of vitamin-K2 (menaquinone-4) on undercarboxylated osteocalcin in women with osteoporosis.https://econtent.hogrefe.com/doi/abs/10.1024/0300-9831/a000554?rfr_dat=cr_pub%3Dpubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&journalCode=vit&
Halder, M., et al. (2019). Vitamin K: Double bonds beyond coagulation insights into differences between vitamin K1 and K2 in health and disease.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413124/
Maresz, K. (2015). Proper calcium use: Vitamin K2 as a promoter of bone and cardiovascular health.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566462/
Shi, J., et al. (2018). Evaluation of the antitumor effects of vitamin K2 (menaquinone-7) nanoemulsions modified with sialic acid-cholesterol conjugate.https://link.springer.com/article/10.1007%2Fs13346-017-0424-1
Tanaka, S., et al. (2017). Comparison of concurrent treatment with vitamin K2 and risedronate compared with treatment with risedronate alone in patients with osteoporosis: Japanese Osteoporosis Intervention Trial-03.https://link.springer.com/article/10.1007/s00774-016-0768-5
Vissers, L. E. T., et al. (2016). The relationship between vitamin K and peripheral arterial disease.https://www.atherosclerosis-journal.com/article/S0021-9150(16)31216-3/fulltext
Vitamin K: Fact sheet for consumers. (2021).https://ods.od.nih.gov/factsheets/VitaminK-Consumer/
Vitamin K: Fact sheet for health professionals. (2021).https://ods.od.nih.gov/factsheets/VitaminK-HealthProfessional/
Xia, J., et al. (2019). Mechanisms of PKC-mediated enhancement of HIF-1α activity and its inhibition by vitamin K2 in hepatocellular carcinoma cells.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429062/

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Medically reviewed by Jared Meacham, PhD., RD, CSCS — Written by Jamie Eske — Updated on November 22, 2023

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