Wnt-C59 | Wnt Signaling Inhibitor - Cellagen Technology

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• Wnt-C59 | Wnt signaling inhibitor

Wnt-C59 | Wnt signaling inhibitor

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See 1 more picture RRP: Price: $159.00 SKU: C7641-2s Brand: Condition: Weight: Rating: ( ) Availability: Shipping: Minimum Purchase: unit(s) Maximum Purchase: unit(s) : Gift Wrapping: * Package Size:

• 2 mg (10 mM solution in DMSO)
• 2 mg (powder)
• 10 mg (powder)
• 50 mg (powder)

Quantity: Buy in bulk and save Bulk Discounts for Wnt-C59 | Wnt signaling inhibitor

Below are the available bulk discount rates for each individual item when you purchase a certain amount

• Buy 3 or above and get 10% off

Product Description

Wnt-C59 was first disclosed in patent WO2010101849 as a potent Wnt signaling modulator. It has IC50 less than 0.11 nM in Wnt-Luc reporter assay for Wnt pathway inhibition. In the study, Wnt-C59 prevents palmitylation of Wnt proteins by Porcupine (Porcn, a membrane-bound O-acyltransferase), thereby blocking Wnt secretion and activity, similar to Wnt inhibitors IWP-2, IWP-3 and IWP-4. But Wnt-C59 is more potent and selective, and has better chemical/physical properties, suitable for in vitro/in vivo studies.

Product Citation

Technical information:

Chemical Formula:	C25H21N3O
CAS #:	1243243-89-1
Molecular Weight:	379.45
Purity:	>98%
Appearance:	Pale Yellow solid
Chemical Name:	2-(4-(2-methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide
Solubility:	Up to 50 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature. Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.

Reference:

1.	Dai Chen et al. (N-(HETERO)ARYL,2-(HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS WNT SIGNALING MODULATORS. PCT WO/2010/101849.
2.	Chen B, Dodge ME, Tang W, Lu J, Ma Z, Fan CW, Wei S, Hao W, Kilgore J, Williams NS, Roth MG, Amatruda JF, Chen C, Lum L. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol. 2009;5(2):100-7.

Other Information:

Product Specification (pdf) MSDS (pdf)

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