X-ray Crystal Structure Of C3d: A C3 Fragment And Ligand ... - PubMed

Clipboard, Search History, and several other advanced features are temporarily unavailable. Skip to main page content

The .gov means it’s official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation Search: Search Advanced Clipboard Save Email Send to

• Clipboard
• My Bibliography
• Collections
• Citation manager

Display options Display options Format Abstract PubMed PMID

Save citation to file

Format: Summary (text) PubMed PMID Abstract (text) CSV Create file Cancel

Email citation

Email address has not been verified. Go to My NCBI account settings to confirm your email and then refresh this page. To: Subject: Body: Format: Summary Summary (text) Abstract Abstract (text) MeSH and other data Send email Cancel

Add to Collections

• Create a new collection
• Add to an existing collection

Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error Please try again Add Cancel

Add to My Bibliography

• My Bibliography

Unable to load your delegates due to an error Please try again Add Cancel

Your saved search

Name of saved search: Search terms: Test search terms Would you like email updates of new search results? Saved Search Alert Radio Buttons

• Yes
• No

Email: (change) Frequency: Monthly Weekly Daily Which day? The first Sunday The first Monday The first Tuesday The first Wednesday The first Thursday The first Friday The first Saturday The first day The first weekday Which day? Sunday Monday Tuesday Wednesday Thursday Friday Saturday Report format: Summary Summary (text) Abstract Abstract (text) PubMed Send at most: 1 item 5 items 10 items 20 items 50 items 100 items 200 items Send even when there aren't any new results Optional text in email: Save Cancel

Create a file for external citation management software

Create file Cancel

Your RSS Feed

Name of RSS Feed: Number of items displayed: 5 10 15 20 50 100 Create RSS Cancel RSS Link Copy

Full text links

Atypon Full text links

Actions

CiteCollectionsAdd to Collections

• Create a new collection
• Add to an existing collection

Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an errorPlease try again Add Cancel PermalinkPermalinkCopyDisplay options Display options Format AbstractPubMedPMID

Page navigation

• Title & authors
• Abstract
• Publication types
• MeSH terms
• Substances
• Associated data
• LinkOut - more resources

Title & authors Abstract Publication types MeSH terms Substances Associated data LinkOut - more resources Full text links CiteDisplay options Display options Format AbstractPubMedPMID

Abstract

Activation and covalent attachment of complement component C3 to pathogens is the key step in complement-mediated host defense. Additionally, the antigen-bound C3d fragment interacts with complement receptor 2 (CR2; also known as CD21) on B cells and thereby contributes to the initiation of an acquired humoral response. The x-ray crystal structure of human C3d solved at 2.0 angstroms resolution reveals an alpha-alpha barrel with the residues responsible for thioester formation and covalent attachment at one end and an acidic pocket at the other. The structure supports a model whereby the transition of native C3 to its functionally active state involves the disruption of a complementary domain interface and provides insight into the basis for the interaction between C3d and CR2.

PubMed Disclaimer

Publication types

• Research Support, Non-U.S. Gov't Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search

MeSH terms

• Amino Acid Sequence Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Animals Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Complement C3d / chemistry* Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Complement C3d / metabolism Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Conserved Sequence Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Crystallography, X-Ray Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Humans Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Ligands Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Models, Molecular Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Molecular Sequence Data Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Mutation Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Protein Conformation Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Protein Structure, Secondary Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Receptors, Complement 3d / metabolism* Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Sequence Alignment Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search

Substances

• Ligands Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Receptors, Complement 3d Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Complement C3d Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search

Associated data

• PDB/UNKNOWN Actions
  • Search in PubMed
  • Search in Structure

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Ovid Technologies, Inc.

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • GlyGen glycoinformatics resource

• Miscellaneous

  • NCI CPTAC Assay Portal

Full text links [x] Atypon [x] Cite Copy Download .nbib .nbib Format: AMA APA MLA NLM Send To

• Clipboard
• Email
• Save
• My Bibliography
• Collections
• Citation Manager

[x]

NCBI Literature Resources

MeSH PMC Bookshelf Disclaimer

The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.