Xi Chen - Memorial Sloan Kettering Cancer Center

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Neurologist

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Areas of Expertise

Conditions I Treat

• Neuromuscular disorders

My Specialties

• Clinical neurophysiology

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Get to Know Me

I am a board-certified neurologist and clinical neurophysiologist. My clinical expertise includes examining the nervous system function using electrodiagnostic tests. My research interest is in diagnosis and management of neuromuscular disorders associated with cancer.

What I Do at MSK

I'm a neurologist, which is a doctor with special training in the brain, spinal cord, nerves, and muscles.

• Director, Clinical Neurophysiology Fellowship Program

Conditions I Treat

• Neuromuscular disorders

My Specialties

• Clinical neurophysiology

Education

• MD, Fujian Medical College

Residencies

• Neurology - New York University Medical Center

Fellowships

• Clinical Neurophysiology - New York University Medical Center

Board Certifications

• Neurology
• Clinical Neurophysiology

Insurance Information

Understanding your insurance options is an important part of managing your cancer care. We have relationships with many common healthcare providers and plans.

Aetna

In Network Coverage TypeHMO, EPO PPO, POS, Transplant

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Aetna Medicare Advantage (MTA and NYC retirees only)

In Network Coverage TypePPO

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Anthem BCBS and other BCBS licensee plans

In Network Coverage TypePPO, POS, EPO, HMO

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Anthem BCBS Health Plus

In Network Coverage TypeHMO

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Blue Cross Blue Shield Federal Employee Program

In Network Coverage TypeHMO, PPO

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Blue Cross Blue Shield states outside of NY/NJ

In Network Coverage TypeHMO, EPO PPO, POS

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Carrum Health

In Network Coverage TypeSupplemental

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Cigna

In Network Coverage TypePPO, POS, HMO

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Connecticare

In Network Coverage TypePOS, EPO, HMO

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Emblem

In Network Coverage TypePPO, POS, EPO, HMO

Offers a qualified health plan from the Health Insurance Marketplace. Call Emblem to learn more.

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Emblem Essential

In Network Coverage TypeHMO

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Emblem Medicare Advantage (Medicare Choice PPO Network and VIP Prime Network Only)

In Network Coverage TypePPO, HMO

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Empire Essential

In Network Coverage TypeHMO

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Empire Plan / NYSHIP (Blue Cross/UnitedHealthcare split plan)

In Network Coverage TypePPO

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Fidelis

In Network Coverage TypeHMO, EPO

Offers a qualified health plan from the Health Insurance Marketplace. Call Fidelis to learn more.

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Fidelis Managed Medicaid & HARP

In Network Coverage TypeHMO

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Fidelis Medicare Advantage

In Network Coverage TypeHMO

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First Health

In Network Coverage TypePPO

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Healthfirst

In Network Coverage TypeEPO, HMO, PPO, POS

Offers a qualified health plan from the Health Insurance Marketplace. Call Healthfirst to learn more.

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Healthfirst Managed Medicaid

In Network Coverage TypeHMO

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Healthfirst Medicare Advantage

In Network Coverage TypeHMO, PPO

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Healthsmart

In Network Coverage TypePPO EPO

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Horizon Blue Cross Blue Shield New Jersey (HMO)

In Network Coverage TypeHMO

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Horizon Blue Cross Blue Shield New Jersey (PPO)

In Network Coverage TypePPO

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Horizon Blue Cross Blue Shield New Jersey Omnia Tier I (EPO)

In Network Coverage TypeEPO

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Horizon Blue Cross Blue Shield New Jersey Omnia Tier II (EPO)

In Network Coverage TypeEPO

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Horizon Medicare Advantage

In Network Coverage TypePPO, HMO

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Husky CT Medicaid

In Network Coverage TypeState Government

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Magnacare

In Network Coverage TypePPO, POS, EPO

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Medicare Part A&B (traditional Medicare)

In Network Coverage TypeFederal Government

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Metroplus

In Network Coverage TypeHMO

City Employee Health Plans (Gold and Gold Care)

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Multiplan/Beech Street/PHCS

In Network Coverage TypeSupplemental

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MVP

In Network Coverage TypePPO/OAP

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Non-Participating Plans with Out of Network Benefits

In Network Coverage TypePPO, POS, EPO, HMO

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NYC Medicare Advantage Plus for City Employees

In Network Coverage TypeTBD

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Oxford

In Network Coverage TypePPO, EPO

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Qualcare

In Network Coverage TypePPO, POS, HMO

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Straight NJ Medicaid

In Network Coverage TypeState Government

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Straight NY Medicaid

In Network Coverage TypeState Government

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Tricare

In Network Coverage TypePPO, HMO

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UMR

In Network Coverage TypePPO, POS

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United Healthcare

In Network Coverage TypePPO, POS, HMO

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World Trade Center Health Program (WTC)

In Network Coverage TypeState Government

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Contact and Location

Office Phone 212-639-7507 Location New York, NY Montvale, NJ Rockefeller Outpatient Pavilion 160 East 53rd Street New York NY 10022 Get Directions Memorial Sloan Kettering Bergen 225 Summit Avenue Montvale NJ 07645 Get Directions

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Colleagues

Doctors at Memorial Sloan Kettering work as teams, with specialists from all different areas. This allows us to consider all your needs together, and to give you the best possible care.

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Clinical Trials

Find a Clinical Trial for You

Memorial Sloan Kettering's doctors and scientists are constantly developing new treatments for cancer. MSK is typically running hundreds of clinical trials at a given time.

You may be able to participate in a clinical trial even if you are new to MSK. Search our online directory to find trial information and see more about who can participate.

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Research and Publications

Ren Y, Xu HW, Davey F, Taylor M, Aiton J, Coote P, Fang F, Yao J, Chen D, Chen JX, Yan SD, Gunn-Moore FJ. Endophilin I expression is increased in the brains of Alzheimer disease patients. J Biol Chem. 2008 Feb 29;283(9):5685-91

Chen JX, Yan SD. Pathogenic role of mitochondrial amyloid-beta peptide. Expert Rev Neurother. 2007 Nov; 7(11): 1517-25.

Yao J, Taylor M, Davey F, Ren Y, Aiton J, Coote P, Fang F, Chen JX, Yan SD, Gunn-Moore FJ. Interaction of amyloid binding alcohol dehydrogenase/Abeta mediates up-regulation of peroxiredoxin II in the brains of Alzheimer’s disease patients and a transgenic Alzheimer’s disease mouse model. Mol Cell Neurosci. 2007 Jun;35(2):377-82. Epub 2007 Apr 1.

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Chen X, Sterio D, Ming X, Para DD, Butusova M, Tong T, Beric A. Success rate of motor evoked potentials for intraoperative neurophysiologic monitoring: effects of age, lesion location, and preoperative neurologic deficits. J Clin Neurophysiol. 2007 Jun;24(3):281-5.

Chen X, Stern D, and Yan SD. Cellular targets of amyloid beta Peptide: potential roles in neuronal stress and toxicity. Chapter 11, Neurobiology of Alzheimer’s Disease (Molucelar and cellular biology series) 3rd edition, Oxford Publications, 2007; pp227-244.

Yan SD, Chen X, and Wu H. ABAD: mitochondrial target for amyloid-induced cellular perturbation relevant to Alzheimer disease.Research Progress in Alzheimer’s Disease and Dementia. Book Chapter, Nova Science Publishers, Inc. 2006

Chen X, Stern D, Yan SD. Mitochondrial dysfunction and Alzheimer’s disease. Curr Alzheimer Res. 2006 Dec;3(5):515-20.

Chen X, Yan SD. Mitochondrial Abeta: a potential cause of metabolic dysfunction in Alzheimer’s disease. IUBMB Life. 2006 Dec;58(12):686-94.

Caspersen C, Wang N, Yao J, Sosunov A, Chen X, Lustbader JW, Xu HW, Stern D, McKhann G, Yan SD. Mitochondrial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer’s disease. FASEB J. 2005 Dec;19(14):2040-1. Epub 2005 Oct 6.

Takuma K, Yao J, Huang J, Xu H, Chen X, Luddy J, Trillat AC, Stern DM, Arancio O, Yan SS. ABAD enhances Abeta-induced cell stress via mitochondrial dysfunction. FASEB J. 2005 Apr;19(6):597-8. Epub 2005 Jan 21.

Arancio O, Zhang HP, Chen X, Lin C, Trinchese F, Puzzo D, Liu S, Hegde A, Yan SF, Stern A, Luddy JS, Lue LF, Walker DG, Roher A, Buttini M, Mucke L, Li W, Schmidt AM, Kindy M, Hyslop PA, Stern DM, Du Yan SS. RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice. EMBO J. 2004 Oct 13;23(20):4096-105. Epub 2004 Sep 30

Lustbader JW, Cirilli M, Lin C, Xu HW, Takuma K, Wang N, Caspersen C, Chen X, Pollak S, Chaney M, Trinchese F, Liu S, Gunn-Moore F, Lue LF, Walker DG, Kuppusamy P, Zewier ZL, Arancio O, Stern D, Yan SS, Wu H. ABAD directly links Abeta to mitochondrial toxicity in Alzheimer’s disease. Science. 2004 Apr 16;304(5669):448-52.

Yan SS, Wu ZY, Zhang HP, Furtado G, Chen X, Yan SF, Schmidt AM, Brown C, Stern A, LaFaille J, Chess L, Stern DM, Jiang H. Suppression of experimental autoimmune encephalomyelitis by selective blockade of encephalitogenic T-cell infiltration of the central nervous system. Nat Med. 2003 Mar;9(3):287-93. Epub 2003 Feb 24.

Du Yan S, Zhu H, Fu J, Yan SF, Roher A, Tourtellotte WW, Rajavashisth T, Chen X, Godman GC, Stern D, Schmidt AM. Amyloid-beta peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: a proinflammatory pathway in Alzheimer disease. Proc Natl Acad Sci U S A. 1997 May 13;94(10):5296-301.

Yan SD, Fu J, Soto C, Chen X, Zhu H, Al-Mohanna F, Collison K, Zhu A, Stern E, Saido T, Tohyama M, Ogawa S, Roher A, Stern D. An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer’s disease. Nature. 1997 Oct 16;389(6652):689-95.

Chen X, Yan SD, Fu J, Herbert J. Genetic assay for multimerization of both normal and mutant transthyretin. Amyloid 1996(3): 245-251.

Pallotti F, Chen X, Bonilla E, Schon EA. Evidence that specific mtDNA point mutations may not accumulate in skeletal muscle during normal human aging. Am J Hum Genet. 1996 Sep;59(3):591-602.

Yan SD, Chen X, Fu J, Chen M, Zhu H, Roher A, Slattery T, Zhao L, Nagashima M, Morser J, Migheli A, Nawroth P, Stern D, Schmidt AM. RAGE and amyloid-beta peptide neurotoxicity in Alzheimer’s disease. Nature. 1996 Aug 22;382(6593):685-91.

Yan SD, Yan SF, Chen X, Fu J, Chen M, Kuppusamy P, Smith MA, Perry G, Godman GC, Nawroth P, et al. Non-enzymatically glycated tau in Alzheimer’s disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid beta-peptide. Nat Med. 1995 Jul;1(7):693-9.

Chen X, Prosser R, Simonetti S, Sadlock J, Jagiello G, Schon EA. Rearranged mitochondrial genomes are present in human oocytes. Am J Hum Genet. 1995 Aug;57(2):239-47.

Chen X, Bonilla E, Sciacco M, Schon EA. Paucity of deleted mitochondrial DNAs in brain regions of Huntington’s disease patients. Biochim Biophys Acta. 1995 May 24;1271(1):229-33.

Schon EA, Sciaco M. Palloti F, Chen X, Bonilla E. Mitochondrial DNA muitations and aging. In: Cellular Aging and Cell Death. Ed: NJ Holbrook, GR Martin, and RA Lockshin, John Wiley-Liss, Inc. 1994: 19-34.

Yan SD, Chen X, Schmidt AM, Brett J, Godman G, Zou YS, Scott CW, Caputo C, Frappier T, Smith MA, et al. Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress. Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7787-91.

Chen X, Ma BL. Trichosanthin, an initiator of the alternative complement activation pathway. Clin Exp Immunol. 1993 Aug;93(2):248-52.

Chen X, Sadlock J, Schon EA. RNA-binding patterns in total human tissue proteins: analysis by northwestern blotting. Biochem Biophys Res Commun. 1993 Feb 26;191(1):18-25.

Chen X, Simonetti S, DiMauro S, Schon EA. Accumulation of mitochondrial DNA deletions in oganisms with various life spans. Bull Mol Biol Med 1993; 18: 57-66.

DiMauro S, Simonetti S, Chen X, Petruzzella V, Hirano M, Shanske S, Moraes CT, Schon EA. Mitochondrial dysfunction as a mechanism of CNS injury. Res Publ Assoc Res Nerv Ment Dis. 1993;71:67-79.

Simonetti S, Chen X, DiMauro S, Schon EA. Accumulation of deletions in human mitochondrial DNA during normal aging: analysis by quantitative PCR. Biochim Biophys Acta. 1992 Dec 10;1180(2):113-22.

Petruzzella V, Chen X, Schon EA. Is a point mutation in the mitochondrial ND2 gene associated with Alzheimer’s disease. Biochem Biophys Res Commun. 1992 Jul 15;186(1):491-7.

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Disclosures

Members of the MSK Community often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community. These activities outside of MSK further our mission, provide productive collaborations, and promote the practical application of scientific discoveries.

MSK requires doctors, faculty members, and leaders to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public. Not all disclosed interests and relationships present conflicts of interest. MSK reviews all disclosed interests and relationships to assess whether a conflict of interest exists and whether formal COI management is needed.

Xi Chen discloses the following relationships and financial interests:

No disclosures meeting criteria for time period

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This page and data include information for a specific MSK annual disclosure period (January 1, 2024 through disclosure submission in spring 2025). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].

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