Xiang-Qun (Sean) Xie, PhD, EMBA

Pubmed: https://pubmed.ncbi.nlm.nih.gov/?term=xiang-qun+xie

Selected Publications

• Xing C, Zhuang Y, Xu T, Feng Z, Xu E, Zhang C and Xie XQ* Cryo-EM Structure of Human Cannabinoid Receptor CB2-Gi Signaling Complex. Cell 2020,180(4):645-654, PMID:32004460. Cell press video: 3D protein structure of CB2-Gi
• Jordan CJ, Feng Z-W, Galaj E, Bi G-H, Xue Y, Liang Y, McGuire T, Xie X-Q*, Xi Z-X*: Xie2-64, a novel CB2 receptor inverse agonist, reduces cocaine abuse-related behaviors in rodents. Neuropharmacology 2020, 176:108241. PMID: 32712273
• Feng Z, Shen M, Chen H, Chen M, Liang T, Xie X-Q*: Virus-CKB: an integrated bioinformatics platform and analysis resource for COVID-19 research. Briefing Bioinformatics Jul 27;bbaa155. PMID: 32715315. DOI: 10.1093/bib/bbaa155. (Impact Factor: 6.312).
• Teramachi J, Rebecca S, Anderson HL, Zhou D, Feng R, Myint KZ, Beumer JH, Eiseman, JL, Windle JL, Xie X-Q*, Roodman D*, Kurihara N*. “Blocking the ZZ Domain of Sequestosome1/p62 Suppresses Myeloma Cell Growth and Osteoclast Formation In Vitro and Induces Dramatic New Bone Formation in Myeloma-Bearing Bones In Vivo” Leukemia, 2016;30:390-8. PMID: 2015:1599270
• Gao Y, Yang P, Shen HM, Yu H, Xie ZJ, … Cheng T* and Xie XQ* “Small-molecule inhibitors targeting INK4 protein p18INK4C enhance ex vivo expansion of haematopoietic stem cells”, Nature Communications, 2015, 6:6328. PMID: 25692908;
• Zhang Y, Wang, LR, Feng ZW, Cheng T, Gao YD and Xie XQ* “StemCellCKB: An Integrated Stem Cell-Specific Chemogenomics Knowledge base for Target Identification and Systems-Pharmacology Research”, J Chem Inf Model. 2016, 56 (10), pp 1995–2004. PMID: 27643925
• Chen M, Jing Y, Feng Z*, andXie X-Q*. DAKB-GPCRs: An Integrated Computational Platform for Drug Abuse Related GPCRs. Chem. Inf. Model. 2019, 59 (4):1283–1289. PMCID: PMC6758544
• Hu Z, Jing Y, Xue Y, Fan P, Wang L, Vanyukov M, Kirisci L, Wang J, Tarter RE and Xie X-Q*. Analysis of Substance Use and Its Outcomes by Machine Learning: II. Derivation and Prediction of the Trajectory of Substance Use Severity. Drug and Alcohol Dependence. 2020, 206:107604; PMID: 31615693.
• Zhang H, Ma SF, Feng ZW, Chai YF, Wang LR and Xie XQ* “Cardiovascular Disease-specific (CVD) Chemogenomics Knowledgebase-guided Target Identification and Drug Synergy Mechanism Study of A Combination of Herbal Medications. Scientific Reports, 2016; 28; 6:33963. DOI:1038/srep33963
• Yang P, Wang L, Feng R, Almehizia AA, Myint KZ, Ouyang Q, Alqarni MH, Xie XQ*: “Novel triaryl sulfonamide derivatives as selective cannabinoid receptor 2 inverse agonists and osteoclast inhibitors: discovery, optimization, and biological evaluation.” J Med Chem 2013, 56(5):2045-2058. PMID: 23406429