XYY Spermatogenesis In XO/XY/XYY Mosaic Mice - PubMed

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Abstract

The relative frequencies of XYY and XY cells in XO/XY/XYY mosaic mice were compared between somatic cells (bone marrow) and spermatogonia, and between spermatogonia and pachytene or MI spermatocytes. The results indicated there was no selection either for or against XYY spermatogonia. There was, however, a strong selection against XYY spermatocytes during pachytene, with their almost total elimination by the first meiotic metaphase. At pachytene, most XYY cells had trivalent or X univalent/YY bivalent configurations. These findings are contrasted with previous studies of XYY spermatogenesis in mice and are discussed with respect to a model that invokes sex-chromosome univalence as the cause of XYY spermatogenic failure.

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• Sex chromosome configurations in pachytene spermatocytes of an XYY mouse. Tease C. Tease C. Genet Res. 1990 Oct-Dec;56(2-3):129-33. doi: 10.1017/s0016672300035205. Genet Res. 1990. PMID: 2272502
• Selective advantage of euploid spermatocytes I in an azoospermic 47,XYY man with gonadal mosaicism. Sciurano RB, Rahn IM, González Arias B, Rey Valzacchi G, Benavente R, Solari AJ. Sciurano RB, et al. Hum Reprod. 2019 Mar 1;34(3):568-573. doi: 10.1093/humrep/dey387. Hum Reprod. 2019. PMID: 30597018
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• The mouse A/HeJ Y chromosome: another good Y gone bad. Hunt PA, Jackson JM, Horan S, Lawson CA, Grindell L, Washburn LL, Eicher EM. Hunt PA, et al. Chromosome Res. 2008;16(4):623-36. doi: 10.1007/s10577-008-1216-8. Epub 2008 May 20. Chromosome Res. 2008. PMID: 18483871
• Persistence of two Y chromosomes through meiotic prophase and metaphase I in an XYY man. Speed RM, Faed MJ, Batstone PJ, Baxby K, Barnetson W. Speed RM, et al. Hum Genet. 1991 Aug;87(4):416-20. doi: 10.1007/BF00197159. Hum Genet. 1991. PMID: 1879828
• Fertile male mice with three sex chromosomes: evidence that infertility in XYY male mice is an effect of two Y chromosomes. Hunt PA, Eicher EM. Hunt PA, et al. Chromosoma. 1991 Jun;100(5):293-9. doi: 10.1007/BF00360527. Chromosoma. 1991. PMID: 1860375
• Sex-chromosome pairing: evidence that the behavior of the pseudoautosomal region differs during male and female meiosis. Hunt PA, LeMaire R. Hunt PA, et al. Am J Hum Genet. 1992 Jun;50(6):1162-70. Am J Hum Genet. 1992. PMID: 1598900 Free PMC article.

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