ZABOFLOXACIN D-ASPARTATE MONOHYDRATE - Inxight Drugs

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ZABOFLOXACIN D-ASPARTATE MONOHYDRATE A09UU5N4TW Investigational Source: NCT01658020: Phase 3 Interventional Completed Chronic Obstructive Pulmonary Disease (2012) Source URL: https://clinicaltrials.gov/ct2/show/NCT01658020 ZABOFLOXACIN D-ASPARTATE MONOHYDRATE A09UU5N4TW Investigational Source: NCT01658020: Phase 3 Interventional Completed Chronic Obstructive Pulmonary Disease (2012) Source URL: https://clinicaltrials.gov/ct2/show/NCT01658020

Details

Stereochemistry ABSOLUTE
Molecular Formula C19H20FN5O4.C4H7NO4.H2O
Molecular Weight 552.5096
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 1
Charge 0
SHOW SMILES / InChI Structure of ZABOFLOXACIN D-ASPARTATE MONOHYDRATE SHOW STEREO... HIDE STEREO...
  • Structure Search

SMILES

O.N[C@H](CC(O)=O)C(O)=O.CO\N=C1/CN(CC12CNC2)C3=C(F)C=C4C(=O)C(=CN(C5CC5)C4=N3)C(O)=O

InChI

InChIKey=CKUBQLBJSAPAGK-WCRXHYIJSA-N InChI=1S/C19H20FN5O4.C4H7NO4.H2O/c1-29-23-14-6-24(9-19(14)7-21-8-19)17-13(20)4-11-15(26)12(18(27)28)5-25(10-2-3-10)16(11)22-17;5-2(4(8)9)1-3(6)7;/h4-5,10,21H,2-3,6-9H2,1H3,(H,27,28);2H,1,5H2,(H,6,7)(H,8,9);1H2/b23-14+;;/t;2-;/m.1./s1 HIDE SMILES / InChI

DescriptionSources: https://clinicaltrials.gov/ct2/show/NCT01658020 | https://clinicaltrials.gov/ct2/show/NCT01081964 | https://www.ncbi.nlm.nih.gov/pubmed/20403681

Zabofloxacin (also known as DW-224a), a fluoroquinolone antibiotic agent, is a dual inhibitor of both DNA gyrase and topoisomerase IV of Streptococcus pneumonia. Zabofloxacin successfully has completed phase III clinical trial in patients with acute bacterial exacerbation of the chronic obstructive pulmonary disease. In addition, in May 2012, IASO terminated phase II trial of oral zabofloxacin capsules in patients with moderate-to-severe community-acquired pneumonia due to financial considerations.

Originator

Dong Wha5Sources: https://adisinsight.springer.com/drugs/800019661

Approval Year

Unknown149124 PubMed

PubMed

TitleDatePubMed
New treatment options for lower respiratory tract infections. 2017-09 28762839
DNA gyrase and topoisomerase IV are dual targets of zabofloxacin in Streptococcus pneumoniae. 2010-07 20403681
Zabofloxacin (DW-224a) activity against Neisseria gonorrhoeae including quinolone-resistant strains. 2008-09 18620833
Safety pharmacology of DW-224a, a novel fluoroquinolone antibiotic agent. 2004-11 15573468
Patents

Patents

201001847955 83242385 WO2008127060A15

Sample Use Guides

In Vivo Use Guide Sources: https://clinicaltrials.gov/ct2/show/NCT01658020 Zabofloxacin 367mg tablet P.O. once daily for 5days and then Placebo P.O. once daily for 2daysRoute of Administration: Oral
Name Type Language
ZABOFLOXACIN D-ASPARTATE MONOHYDRATE Sources:
Common Name English
Zabofloxacin d-aspartate hydrate [WHO-DD] Source:
Preferred Name English
D-ASPARTIC ACID, 1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-7-((8Z)-8-(METHOXYIMINO)-2,6-DIAZASPIRO(3.4)OCT-6-YL)-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLATE, HYDRATE (1:1:1) Source:
Systematic Name English
Code System Code Type Description
FDA UNII
A09UU5N4TW Created by admin on Tue Apr 01 21:25:43 GMT 2025 , Edited by admin on Tue Apr 01 21:25:43 GMT 2025 PRIMARY
SMS_ID Source:
100000182643 Created by admin on Tue Apr 01 21:25:43 GMT 2025 , Edited by admin on Tue Apr 01 21:25:43 GMT 2025 PRIMARY
EVMPD Source:
SUB196892 Created by admin on Tue Apr 01 21:25:43 GMT 2025 , Edited by admin on Tue Apr 01 21:25:43 GMT 2025 PRIMARY
PUBCHEM Source:
131633976 Created by admin on Tue Apr 01 21:25:43 GMT 2025 , Edited by admin on Tue Apr 01 21:25:43 GMT 2025 PRIMARY
CAS Source:
1808295-60-4 Created by admin on Tue Apr 01 21:25:43 GMT 2025 , Edited by admin on Tue Apr 01 21:25:43 GMT 2025 PRIMARY
PARENT (SALT/SOLVATE) LV66BA6V2G Structure of ZABOFLOXACIN ZABOFLOXACIN SUBSTANCE RECORD A09UU5N4TW Structure of ZABOFLOXACIN D-ASPARTATE MONOHYDRATE ZABOFLOXACIN D-ASPARTATE MONOHYDRATE NIH NCATS PRIVACY NOTICE ACCESSIBILITY DISCLAIMER HHS VULNERABILITY DISCLOSURE For language access assistance, contact the NCATS Public Information Officer National Center for Advancing Translational Sciences (NCATS), 6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966 version 1.1

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