C-reactive Protein | Diagnostic Laboratory Of Oklahoma

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C-reactive Protein

Test Code: 4420

CPT Code(s): 86140

Methodology: Nephelometry

Limitations: Oral contraceptives, IUDs, pregnancy, and menstruation may raise CRP levels. Levels are lowest during ovulation.

Clinical Significance: Increased CRP levels are found in inflammatory conditions including: bacterial infection, rheumatic fever, active arthritis, myocardial infarction, malignancies and in the post-operative state. This test cannot detect the relatively small elevations of CRP that are associated with increased cardiovascular risk.

Alternative Name(s): CRP

Collection Guide

Supply: #T157 Red/Yellow SST 8mL

Preferred Specimen: Serum

Preferred Volume: 1mL

Transport Container: Serum Separator Tube (SST)

Transport Temperature: Room Temperature

Specimen Stability: Room Temperature: 7 days

Rejection Criteria:

• Hemolysis
  • What are hemolyzed specimens?
    • Hemolysis occurs when the red cells are damaged during sample collection causing them to rupture. Hemolyzed serum or plasma is pale pink to red rather than the normal clear straw or pale-yellow color.
  • What causes a specimen to be hemolyzed?
    • Mixing tubes too vigorously
    • Placing tubes in the refrigerator without allowing 30 minutes at room temperature for complete clotting
    • Exposure to heat or in a refrigerator that is too cold
    • Using a needle with too small of a bore necessary for the venipuncture
    • Using too large a tube when using a butterfly needle
    • Not allowing sufficient time for alcohol to dry on puncture site
    • Leaving the tourniquet on for longer than one minute
  • How can hemolyzed specimens be prevented?
    • For routine collections, use a 20–22-gauge needle
    • Do not remove the needle from the vein with the vacuum tube engaged
    • Do not collect a specimen in a hematoma
    • Do not centrifuge the specimen for a prolonged period of time
    • Draw the sample gently and evenly
• Specimens exceeding stability
• Specimens other than serum
• Unlabeled or improperly labeled specimens

For additional supply or collection device information, please contact DLO's Customer Service at (800) 891-2917, option 2.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the Payor being billed.

Cardiology Immunology Infectious Disease Primary Care A-C Test Listings Additional names CRP CPT Code(s) 86140 Test Code 4420

• Patients
  • Patient Bill Pay
    • Upfront Payment Program
  • Patient Lab Results
    • Create a MyQuest Account
  • Order Your Own Lab Tests/QuestHealth™
  • Insurance List
  • Testing
    • Choose to Know for Patients
      • Cardiovascular Disease
      • Cervical Cancer
      • Sexually Transmitted Infections
      • Syphilis
      • Thyroid Conditions
  • Quest Diagnostics
  • Patient FAQ
  • Locations
• Providers
  • Become a DLO client
  • Services Offered
  • Billing and Payments
  • Quanum® Lab Services - Ordering & Results
  • DLO Go Kit Training Manual
  • Medicare Limited Coverage Policies (MLCP)
  • PECOS Enrollment
  • Testing
    • Choose to Know for Providers
      • Cardiovascular Disease in Oklahoma
      • HPV & Pap Co-testing for Cervical Cancer
      • Hormone Testing for Men and Women
      • Sexually Transmitted Infections
      • Testing to reduce Prescription Drug Abuse
  • Supply Catalog
  • Tools and Resources
    • ICD-10 and CPT 2025
    • ICD-10 and CPT 2024
    • ICD-10 and CPT 2023
    • ICD-10 and CPT 2022
    • ICD-10 and CPT 2021
    • IntelliTest Manager
    • Provider Forms
    • Priority Result Reporting Policy
    • Specimen Collection Charts
  • HLA Lab
  • Online Specimen Pickup Scheduling
• Virtual Test Guide
  • Lock Box Usage Instructions
  • Quest Diagnostics Test Directory
  • Virtual Test Guide Comment Form
• Locations
• About
  • Mission, Vision & Values
  • Leadership Team
  • Central Lab and Corporate Headquarters
  • Community Involvement
  • Accreditations
  • Media Kit
  • News
• Careers
  • Job Search
  • Job Descriptions
    • Client Services Representative
    • Medical Technologist / Clinical Laboratory Scientist
    • Phlebotomy Services Representative
    • Route Service Representative
    • Specimen Preparation Technician
  • Benefits
    • General Employee Information
    • My Health
    • My Life
    • My Wealth
  • Workforce Diversity