Frequently Asked Questions | LINZESS (linaclotide)

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FAQs

 

Frequently Asked Questions About IBS-C, CIC & LINZESS

 

IBS-C, CIC & Chronic Constipation

What’s the difference between occasional and chronic constipation?

Sudden or short periods of difficult, infrequent, or incomplete bowel movements may be occasional constipation. Constipation symptoms that keep coming back or seem to last for a long time—more than 3 months—could indicate a medical condition known as chronic constipation.

Irritable Bowel Syndrome with Constipation (IBS-C) and Chronic Idiopathic Constipation (CIC) are types of chronic constipation.

Is there a cure for IBS-C or CIC?

There is no known cure for IBS-C or CIC, but LINZESS can help you proactively manage your symptoms and is proven to treat multiple symptoms of IBS-C. Healthy diet and lifestyle habits may also help you manage your symptoms.

 

What LINZESS Does & How it Can Help

How is LINZESS different than a laxative?

LINZESS can help you proactively manage symptoms of IBS-C or CIC. It was the first approved treatment in a class of drugs that work differently than other medications. The once-daily prescription acts locally in the intestine and is thought to work in 2 ways: by helping to calm pain-sensing nerves* and by accelerating bowel movements.

*This was seen in animal studies, and the relevance to humans is not known.

What does LINZESS do?

LINZESS helps you have more frequent and complete bowel movements and helps relieve belly pain and overall abdominal symptoms* (pain, discomfort, and bloating) associated with IBS-C.

*Abdominal symptoms were studied in combination, not individually.

When can I expect to start seeing my symptoms improve with LINZESS?

Constipation relief is typically felt in about 1 week. IBS-C patients may begin to experience relief of belly pain and overall abdominal symptoms* (pain, discomfort, and bloating) in about 1 week, with symptoms typically improving over 12 weeks.

*Abdominal symptoms were studied in combination, not individually.

 

Getting Treatment & More Resources

How do I start a conversation with a doctor about my symptoms?

In order to help you find the right treatment, your doctor needs to know all of your symptoms and how they’re affecting you. The quick 5-question Gut Check helps summarize your symptoms. You can then use your summary as a conversation guide when speaking to the doctor.

Besides talking to a doctor, where else can I find information about IBS-C or CIC?

The following resources can help you learn more or stay informed about your condition.

Helpful Links for IBS-C

American College of Gastroenterology

Healthline

IBS Patient

My GI Health

National Digestive Diseases Information Clearinghouse

WebMD

Helpful Links for CIC

American College of Gastroenterology

International Foundation for Functional Gastrointestinal Disorders

My GI Health

National Digestive Diseases Information Clearinghouse

WebMD

 

Your LINZESS Prescription

How much does LINZESS cost?

Check the Financial Support page to learn more about the cost of LINZESS and the LINZESS savings card.

Why do I need to take LINZESS daily?

LINZESS was studied and shown to be effective when taken once daily. When taken daily as prescribed by your doctor, LINZESS may help you proactively manage your symptoms of IBS-C or CIC. If you stop taking LINZESS, your symptoms may return in about 1 week.

What is the best time of day to take LINZESS?

Take LINZESS on an empty stomach, at least 30 minutes before a meal at approximately the same time each day. Remember to take LINZESS daily, as prescribed by your doctor, to proactively manage your symptoms.

How do I know if LINZESS is working for me?

When LINZESS is taken daily, your constipation and abdominal symptoms may improve over time. Constipation relief is typically felt in about 1 week. IBS-C patients may begin to experience relief of belly pain and overall abdominal symptoms* (pain, discomfort, and bloating) in about 1 week, with symptoms typically improving over 12 weeks.

*Abdominal symptoms were studied in combination, not individually.

Is it common to experience diarrhea when starting LINZESS?

Diarrhea is the most common side effect of LINZESS and can sometimes be severe. Diarrhea often begins within the first 2 weeks of treatment. Stop taking LINZESS and call your doctor right away if you experience severe diarrhea while taking LINZESS.

What should I do if I experience any severe side effects?

Call your doctor or go to the nearest emergency room right away if you develop unusual or severe stomach-area (abdominal) pain, especially if you also have bright red, bloody stools or black stools that look like tar.

Where should I store LINZESS?

LINZESS should be stored at room temperature (68°F-77°F). It is important to keep LINZESS in the bottle it comes in. Keep your LINZESS bottle tightly closed in a dry place. Do not remove the desiccant (drying agent) from the bottle.

Check My Symptoms

Learn More

How LINZESS Can Help

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USES

LINZESS® (linaclotide) is a prescription medication used to treat irritable bowel syndrome with constipation (IBS-C) in adults and in children and adolescents 7 years of age and older, chronic idiopathic constipation (CIC) in adults, and functional constipation (FC) in children and adolescents 6 years of age and older. “Idiopathic” means the cause of the constipation is unknown. It is not known if LINZESS is safe and effective in children with functional constipation less than 6 years of age or in children with IBS-C less than 7 years of age.

IMPORTANT RISK INFORMATION

• Do not give LINZESS to children who are less than 2 years of age. It may harm them. LINZESS can cause severe diarrhea and your child could get severe dehydration (loss of a large amount of body water and salt). 
• Do not take LINZESS if a doctor has told you that you have a bowel blockage (intestinal obstruction).

Before you take LINZESS, tell your doctor about your medical conditions, including if you are:

• Pregnant or plan to become pregnant. It is not known if LINZESS will harm your unborn baby.
• Breastfeeding or plan to breastfeed. You and your doctor should decide if you will take LINZESS and breastfeed.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Side Effects

LINZESS can cause serious side effects, including diarrhea, which is the most common side effect and can sometimes be severe. Diarrhea often begins within the first 2 weeks of LINZESS treatment. Stop taking LINZESS and call your doctor right away if you get severe diarrhea during treatment with LINZESS.

Other common side effects of LINZESS in people with IBS-C and CIC include gas, stomach-area (abdomen) pain, and swelling, or a feeling of fullness or pressure in your abdomen (distention).

Call your doctor or go to the nearest hospital emergency room right away if you develop unusual or severe stomach-area (abdomen) pain, especially if you also have bright red, bloody stools or black stools that look like tar.

These are not all the possible side effects of LINZESS. For more information, ask your doctor or pharmacist. 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you are having difficulty paying for your medicine, AbbVie and Ironwood may be able to help. Visit AbbVie.com/PatientAccessSupport to learn more.

Please see full Prescribing Information, including Boxed Warning, and Medication Guide.

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For adults with Irritable Bowel Syndrome with Constipation (IBS-C) or Chronic Idiopathic Constipation (CIC)

TALK TO A DOCTOR ONLINE TODAY*

Answer a few quick questions about your symptoms.

Connect with a doctor online to find out if it could be IBS-C or CIC.

If approved, pick up your prescription from your local pharmacy.

*Third-party website; does not constitute an endorsement or recommendation by AbbVie. A fee will be charged by the telemedicine provider.

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By clicking “Acknowledge and Continue” above, you acknowledge and agree that neither AbbVie nor Ironwood does, in any way, endorse or recommend UpScript, a telemedicine provider, the qualifications of any physician associated with UpScript, or the quality of medical care any of those physicians can provide. You also acknowledge and agree that neither AbbVie nor Ironwood makes any guarantees that using UpScript will result in your desired outcome. It is wholly and solely your responsibility to assess the qualifications of a potential physician. AbbVie and Ironwood recommend that you meet and discuss the benefits and risks of all potential treatments with the potential physician. ABBVIE, IRONWOOD, AND THEIR RESPECTIVE AFFILIATES HEREBY DISCLAIM ANY LIABILITY ARISING FROM YOUR USE AND/OR RELIANCE ON THE INFORMATION CONTAINED ON THE UPSCRIPT WEBSITE. If you agree to the above, click “Acknowledge and Continue” to proceed to the UpScript website. If you do not agree to the above, click “Cancel” to remain on LINZESS.com.

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Did you know you can talk to a doctor today from the comfort of your home? Connect with a healthcare professional online about your symptoms.

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USES

LINZESS® (linaclotide) is a prescription medication used to treat irritable bowel syndrome with constipation (IBS-C) in adults and in children and adolescents 7 years of age and older, chronic idiopathic constipation (CIC) in adults, and functional constipation (FC) in children and adolescents 6 years of age and older. “Idiopathic” means the cause of the constipation is unknown. It is not known if LINZESS is safe and effective in children with functional constipation less than 6 years of age or in children with IBS-C less than 7 years of age.

IMPORTANT RISK INFORMATION

• Do not give LINZESS to children who are less than 2 years of age. It may harm them. LINZESS can cause severe diarrhea and your child could get severe dehydration (loss of a large amount of body water and salt).
• Do not take LINZESS if a doctor has told you that you have a bowel blockage (intestinal obstruction).

Before you take LINZESS, tell your doctor about your medical conditions, including if you are:

IMPORTANT RISK INFORMATION

• Do not give LINZESS to children who are less than 2 years of age. It may harm them. LINZESS can cause severe diarrhea and your child could get severe dehydration (loss of a large amount of body water and salt).

USES

LINZESS® (linaclotide) is a prescription medication used to treat irritable bowel syndrome with constipation (IBS-C) in adults and in children and adolescents 7 years of age and older, chronic idiopathic constipation (CIC) in adults, and functional constipation (FC) in children and adolescents 6 years of age and older. “Idiopathic” means the cause of the constipation is unknown. It is not known if LINZESS is safe and effective in children with functional constipation less than 6 years of age or in children with IBS-C less than 7 years of age.

IMPORTANT RISK INFORMATION

• Do not give LINZESS to children who are less than 2 years of age. It may harm them. LINZESS can cause severe diarrhea and your child could get severe dehydration (loss of a large amount of body water and salt).
• Do not take LINZESS if a doctor has told you that you have a bowel blockage (intestinal obstruction).

Before you take LINZESS, tell your doctor about your medical conditions, including if you are:

IMPORTANT RISK INFORMATION

• Do not give LINZESS to children who are less than 2 years of age. It may harm them. LINZESS can cause severe diarrhea and your child could get severe dehydration (loss of a large amount of body water and salt).

USES

LINZESS® (linaclotide) is a prescription medication used to treat irritable bowel syndrome with constipation (IBS-C) in adults and in children and adolescents 7 years of age and older, chronic idiopathic constipation (CIC) in adults, and functional constipation (FC) in children and adolescents 6 years of age and older. “Idiopathic” means the cause of the constipation is unknown. It is not known if LINZESS is safe and effective in children with functional constipation less than 6 years of age or in children with IBS-C less than 7 years of age.

IMPORTANT RISK INFORMATION

• Do not give LINZESS to children who are less than 2 years of age. It may harm them. LINZESS can cause severe diarrhea and your child could get severe dehydration (loss of a large amount of body water and salt). 
• Do not take LINZESS if a doctor has told you that you have a bowel blockage (intestinal obstruction).

Before you take LINZESS, tell your doctor about your medical conditions, including if you are:

• Pregnant or plan to become pregnant. It is not known if LINZESS will harm your unborn baby.
• Breastfeeding or plan to breastfeed. You and your doctor should decide if you will take LINZESS and breastfeed.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Side Effects

LINZESS can cause serious side effects, including diarrhea, which is the most common side effect and can sometimes be severe. Diarrhea often begins within the first 2 weeks of LINZESS treatment. Stop taking LINZESS and call your doctor right away if you get severe diarrhea during treatment with LINZESS.

Other common side effects of LINZESS in people with IBS-C and CIC include gas, stomach-area (abdomen) pain, and swelling, or a feeling of fullness or pressure in your abdomen (distention).

Call your doctor or go to the nearest hospital emergency room right away if you develop unusual or severe stomach-area (abdomen) pain, especially if you also have bright red, bloody stools or black stools that look like tar.

These are not all the possible side effects of LINZESS. For more information, ask your doctor or pharmacist. 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you are having difficulty paying for your medicine, AbbVie and Ironwood may be able to help. Visit AbbVie.com/PatientAccessSupport to learn more.

Please see full Prescribing Information, including Boxed Warning, and Medication Guide.

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