Linzess | Side Effects | Dosage | Precautions | Medicine

Linzess tablet is a prescription medication commonly used to treat gastrointestinal conditions such as Irritable Bowel Syndrome with Constipation (IBS-C) and Chronic Idiopathic Constipation (CIC). It improves bowel function by increasing fluid secretion in the intestines, making stools softer, and promoting regular bowel movements.

What is Linzess Tablet?

Linzess (linaclotide) tablet belongs to a class of drugs known as guanylate cyclase-C agonists. It works by enhancing intestinal fluid secretion and transit, helping relieve symptoms such as bloating, straining, and infrequent bowel movements. Linzess is typically prescribed when dietary changes and over-the-counter laxatives do not provide relief.

What are the Uses of the Linzess Tablets?

Linzess tablets are mainly used to treat chronic constipation and irritable bowel syndrome with constipation (IBS-C). They help improve bowel movements by increasing fluid secretion in the intestines. This action softens stools and reduces discomfort, bloating, and abdominal pain, offering relief to patients who struggle with regularity and digestive discomfort. Always follow your doctor's guidance. Linzess is primarily used to manage:

• Irritable Bowel Syndrome with Constipation (IBS-C)
• Chronic Idiopathic Constipation (CIC)
• Its benefits include:
• Softening of stools
• Promoting regular and complete bowel movements
• Reducing abdominal discomfort, bloating, and gas

Conditions Linzess Treats

• Irritable Bowel Syndrome with Constipation (IBS-C)
• Chronic Idiopathic Constipation (CIC)

Secondary Uses of Linzess

Though not officially approved for other conditions, Linzess may be considered in some instances of treatment-resistant constipation when other options fail under the guidance of a physician.

How Does Linzess Tablet Work?

Linzess tablet works by stimulating guanylate cyclase-C receptors on the intestinal lining, increasing cyclic GMP levels. This process boosts the secretion of chloride and water into the intestines, helping to soften stools. As a result, bowel movements become easier, intestinal motility improves, and symptoms related to constipation are effectively relieved, offering smoother digestive function and comfort.

Linzess Tablet Dosage

Linzess tablet dosage typically depends on the condition being treated. For adults with chronic constipation, the usual dose is 145 mcg once daily, taken on an empty stomach. For IBS with constipation, 290 mcg once daily is recommended. Always follow your doctor's instructions and avoid adjusting the dosage without medical advice. Learn about the recommended dosage guidelines for Linzess and how it's typically taken for optimal results.

• For IBS-C: 290 mcg orally once daily
• For CIC: 145 mcg orally once daily; 72 mcg may be used in certain patients based on response or tolerability
• Take Linzess at least 30 minutes before your first meal of the day on an empty stomach. Swallow the capsule whole, or mix its contents with a teaspoon of applesauce if swallowing is difficult.

What Should I Do If I Miss a Dose?

If you miss a dose of Linzess, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue your regular schedule. Do not double up to make up for the missed dose.

What Happens If an Overdose?

An overdose of Linzess may cause severe diarrhea or dehydration. Seek immediate medical help if you experience dizziness, fainting, or signs of severe fluid loss.

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What are the Side Effects of Linzess Tablets?

Linzess tablets may cause some side effects, which can vary from person to person. Common side effects include diarrhea, gas, stomach pain, and bloating. In rare cases, more serious issues like severe diarrhea or allergic reactions can occur. Always consult your doctor if you notice any unusual or persistent symptoms. Understand the possible side effects that may occur while using Linzess, from common reactions to more serious ones.

Common Side Effects:

• Diarrhea
• Abdominal pain
• Gas
• Bloating

Serious Side Effects:

• Severe diarrhea with dizziness or lightheadedness
• Dehydration (increased thirst, dry mouth, leg cramps)
• Irregular heartbeat or chest fluttering
• Muscle weakness or a limp feeling

Contact your doctor immediately if you experience any severe symptoms or allergic reactions.

Precautions and Warnings for Linzess Tablets

Find out what safety considerations you should be aware of before starting Linzess, including who should use it with caution.

• Do not use Linzess if you have a known allergy to linaclotide or any inactive ingredients in the formulation.
• Avoid use if you have a history of gastrointestinal obstruction or suspected bowel blockage.
• Caution is advised in patients with severe kidney failure or lung problems.

Are There Any Age Restrictions for Using Linzess?

Linzess is not approved for use in children under 18 years of age due to the risk of severe dehydration.

Alcohol or Food Interactions

Linzess should be taken on an empty stomach. Alcohol doesn't have a direct interaction, but excessive intake may worsen digestive symptoms and reduce the medicine's effectiveness.

Possible Interactions with Other Medications (Drug Interactions)

Linzess is not known to have major drug interactions, but it's important to inform your doctor about all medications you use. This includes any prescription drugs, over-the-counter treatments, herbal supplements, or vitamins. Sharing this information ensures safe use of Linzess and helps avoid any unexpected side effects or complications.

How Should Linzess Tablets Be Stored?

Linzess tablets should be stored at room temperature, away from moisture, heat, and direct sunlight. Keep them in their original packaging to protect them from humidity. Do not store in the bathroom. Always keep the medicine out of reach of children and pets, and never use expired tablets. Dispose of properly as advised. Learn about the correct storage method for Linzess to maintain its effectiveness and ensure its continued safety for use.

• Store Linzess at room temperature: 68ºF to 77ºF (20ºC to 25ºC)
• Keep the capsules in the original blister pack until use
• Protect from heat, moisture, and direct sunlight
• Keep out of reach of children

What Happens If Linzess Is Not Stored Properly?

Improper storage may reduce the effectiveness of the medication. Moisture or heat can degrade the contents, so it is essential to store it as directed to maintain its stability and potency.

Linzess Vs Bisacodyl

Linzess	Bisacodyl
Linzess is a medication used to treat symptoms of Irritable Bowel Syndrome (IBS) and Chronic Idiopathic Constipation. Linzess may be used on its own or with other medicines.	Bisacodyl is an over-the-counter medication used to treat constipation. It is a stimulant laxative that works by increasing bowel movement and helping stool pass.
Linzess is prescribed for gastrointestinal issues such as irritable bowel syndrome with constipation and chronic idiopathic constipation.	Bisacodyl is used to relieve constipation and is also used before intestinal or surgical procedures for bowel cleansing.
Some serious side effects include Diarrhea with dizziness Lightheadedness Increased thirst or urination Leg cramps Feeling unsteady	Some serious side effects include Dizziness Blood in stool Vomiting Vertigo Abdominal cramping Rectal burning

References

Linzess: A Novel Treatment Option for Constipation Associated with Irritable Bowel Syndrome Linaclotide Capsules (Linzess)