Osmosis Jones - Where To Watch And Stream - TV Guide

X Close Ad

Join or Sign In

Sign in to customize your TV listings

Continue with Facebook Continue with email

By joining TV Guide, you agree to our Terms of Use and acknowledge the data practices in our Privacy Policy.

• Live & Upcoming Live & Upcoming
  • TV Schedule
  • New Tonight
  • Streaming
  • Live Sports
  New This Month
  • The Ultimate Guide to What to Watch on Netflix, Hulu, Prime Video, HBO Max, and More in February 2026
  • New and Upcoming Netflix Shows and Movies
  • New and Upcoming Hulu Shows and Movies
  • What's New on and Coming to Max and HBO
  • Everything New on and Coming to Amazon Prime Video
• Shopping Shopping
  • The 5 Best Live TV Streaming Services in 2025
  • 7 Prime Video Add-Ons That'll Supercharge Your Streaming Lineup
  • What Is a VPN?
  • How to Get an ESPN+ Free Trial in 2025
  The Latest
  • Where to Watch RuPaul's Drag Race Season 18 in 2026
  • Where to Watch Los Angeles Chargers vs New England Patriots Game on Jan. 11
  • Where to Watch San Francisco 49ers vs Philadelphia Eagles Game on Jan. 11
  • Where to Watch Buffalo Bills vs Jacksonville Jaguars Game on Jan. 11
• What to Watch What to Watch
  • The New Winter 2025-2026 Shows
  • The Big Winter TV Guide
  • Recommendations Newsletter
  • The Best Shows on Netflix Right Now
  • The Best Shows on Hulu Right Now
  • The Best Shows on Prime Video Right Now
  • The Best Shows on HBO Max Right Now
  If You Like...
  • 8 Epic Fantasy Shows Like The Wheel of Time to Watch Next
  • 8 Shows Like The Summer I Turned Pretty
  • 8 Shows Like Severance to Watch Next
  • 8 Shows Like Netflix's Adolescence
• News News
  • Latest News
  • Shopping and Best TV Deals
  • TV Recommendations Newsletter
  The Latest News on Your Favorite Shows
  • Paradise Season 2: What to Expect in the Thriller's Next Chapter
  • Landman Season 2: Expect More Demi Moore
  • The Summer I Turned Pretty Season 3 Is Oh So Close Now
  • Neagley: Everything to Know About the Reacher Spin-Off Show
  • Star Trek: Strange New Worlds Season 3 Has an Exciting New Trailer

• Overview
• Cast & Crew
• TV Listings
• Trailers & Videos

Osmosis Jones

• Watchlist

• 57   Metascore
• 2001
• 1 hr 35 mins
• Animation, Action & Adventure, Comedy, Suspense, Family, Fantasy, Science Fiction
• PG

• Watchlist

• Watchlist

Frank Detorre is a slovenly zookeeper and widowed father to his daughter, Shane. He catches a cold right after he swallows a germ-ridden egg. The inside of his body is known as the "City of Frank". An unlikely hero of a white blood cell named Osmosis Jones works as a member of Immunity cell. But with that egg comes a mortal danger: Osmosis discovers that Frank has really contracted a villainous and black-hearted deadly virus known as Thrax who arrives and is plotting to ultimately overheat his body, killing him from the inside out. Thrax is motivated by trying to become the nastiest new virus, attempting to kill each new victim faster than the previous ones. His grandiose plan for Frank is death in 48 hours, breaking previous medical records. Meanwhile the cold pill that Frank took, Drix, arrives in his body and covers his throat with ice to cover the irritation. Osmosis becomes his newest partner. Now it's all up to them to put an end of Thrax's plans before Frank dies and Shane becomes an orphan.

• Streaming
• Airings

Loading. Please wait...

Content not available in your region? ExpressVPN can help you stay connected wherever you are. Get 4 extra months FREE with TV Guide's exclusive offer.

Cast & Crew See All

Laurence Fishburne

Thrax

Chris Rock

Osmosis Jones

David Hyde Pierce

Drix

See Full Cast & Crew

Featured Video

Osmosis Jones 1:11 Watch Now

1:11 Osmosis Jones

Trailers & Videos See All

Osmosis Jones

1:11 See All Trailers & Videos

Awards

• 2002 - Golden Reel Award - Best Sound Editing - Animated Feature Film, Domestic and Foreign - nominated
• 2001 - Annie - Outstanding Achievement in an Animated Theatrical Feature - nominated
• 2001 - Annie - Outstanding Individual Achievement for Character Animation - nominated
• 2001 - Annie - Outstanding Individual Achievement for Effects Animation - nominated

You May Also Like See All

Celine and Julie Go Boating

Pinocchio

Singin' in the Rain

City Lights

Popular Movies See all movies

Sing 2

1 hr 50 mins With his theatrical company a local success, Buster Moon is dreaming of bigger things. Unfortunately, when a talent scout dismisses their work as inadequate for the big time, Buster is driven to prove her wrong, and he inspires his players to gamble everything to sneak into a talent audition in Redshore City for demanding entertainment mogul Jimmy Crystal. Against the odds, they catch his interest with some frantic creative improvisation and even more desperate lies, like personally knowing reclusive rock star Clay Calloway, who has not been seen in 15 years. Now faced with a tight production window with only a vague story idea and dire consequences for failure, Buster and his friends must all stretch their talents put on a show. The gang's challenges seem insurmountable, but each of them finds new inspirations and friends where they least expect them to pursue an artistic dream worthy of them. 49   Metascore 2021 Animation, Action & Adventure, Comedy, Family, Music Watchlist Where to Watch

Cars

1 hr 56 mins Hotshot race car Lightning McQueen (Owen Wilson) is living life in the fast lane...until he hits a detour and gets stranded in Radiator Springs, a forgotten town on Route 66. There he meets Sally, Mater, Doc Hudson (Paul Newman) and a heap of hilarious characters who help him discover there's more to life than trophies and fame. 73   Metascore 2006 Animation, Action & Adventure, Comedy, Family, Sports Watchlist Where to Watch

Our Friend, Martin

1 hr 0 mins This is the story of a Black teenager named Miles, who goes on a class field trip to the museum of learning what Dr. Martin Luther King, Jr. did for humanity, but at first his mind is focused on wishing he could be playing baseball instead. But the trip turns into an exciting adventure when he and his best friend Randy, who is white, are sent back in time, where they meet Dr. Martin Luther King, Jr. at several points during his life. 1999 Animation, Action & Adventure, Drama, Family, Documentary Watchlist Where to Watch

Space Jam

1 hr 28 mins Swackhammer, owner of the amusement park planet Moron Mountain is desperate get new attractions and he decides that the Looney Tune characters would be perfect. He sends his diminutive underlings to get them to him, whether Bugs Bunny and Co. want to go or not. Well armed for their size, Bugs Bunny is forced to trick them into agreeing to a competition to determine their freedom. Taking advantage of their puny and stubby legged foes, the gang selects basketball for the surest chance of winning. However, the Nerdlucks turn the tables and steal the talents of leading professional basketball stars to become massive basketball bruisers known as the Monstars. In desperation, Bugs Bunny calls on the aid of Michael Jordan, the Babe Ruth of basketball, to help them have a chance at winning their freedom. 57   Metascore 1996 Animation, Action & Adventure, Comedy, Family, Fantasy, Science Fiction, Sports Watchlist Where to Watch

Madagascar

1 hr 26 mins Spoiled by their upbringing with no idea what wild life is really like, four animals from New York Central Zoo escape, unwittingly assisted by four absconding penguins, and find themselves in Madagascar, among a bunch of merry lemurs. 57   Metascore 2005 Animation, Action & Adventure, Comedy, Family Watchlist Where to Watch

The Lego Movie

1 hr 40 mins The LEGO Movie is a 3D animated film which follows lead character, Emmet, a completely ordinary LEGO mini-figure who is identified as the most "extraordinary person" and the key to saving the Lego universe. Emmet and his friends go on an epic journey to stop the evil tyrant, Lord Business. 83   Metascore 2014 Animation, Action & Adventure, Comedy, Family, Fantasy, Science Fiction Watchlist Where to Watch