Quantification Of Stroke Volume In A Simulated Healthy Volunteer ...

Comparison of change from baseline values for SVTTE and SVTEB / SVSSD

Four quadrant plots comparing changes in SV from baseline for TTE (ΔSVTTE) and SSD (ΔSVSSD) are shown in Fig 4. In the non-tourniquet strand 119 paired measurements were made, ΔSVTTE and ΔSVSSD were positively correlated (r = 0.65, p<0.0001) with a 91% concordance rate. In the tourniquet strand 113 paired measurements were made, ΔSVTTE and ΔSVSSD were positively correlated (r = 0.75, p<0.0001) with a concordance rate of 90%.

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Fig 4. 4 quadrant plot showing changes in stroke volume from baseline (ΔSV) recorded using trans thoracic bioimpedence (TBI) and trans-thoracic echocardiography (TTE).

15% exclusion zone shown as dotted central square. Line of identity (y = x) shown as dotted line and regression line shown as solid line. r value indicates degree of correlation (Pearson’s co-efficient).

https://doi.org/10.1371/journal.pone.0261546.g004

Four quadrant plots comparing changes in SV from baseline for TTE (ΔSVTTE) and TEB (ΔSVTEB) are shown in Fig 5. In the non-tourniquet strand 121 paired measurements were made, ΔSVTTE and ΔSVTEB were positively correlated (r = 0.41, p<0.0001) with a 86% concordance rate. In the tourniquet strand 112 paired measurements were made, ΔSVTTE and ΔSVTEB were positively correlated (r = 0.78, p<0.0001) with a 93% concordance rate.

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Fig 5. 4 quadrant plot showing changes in stroke volume from baseline (ΔSV) recorded using supra-sternal Doppler (SSD) and trans-thoracic echocardiography (TTE).

15% exclusion zone shown as dotted central square. Line of identity (y = x) shown as dotted line and regression line shown as solid line. r value indicates degree of correlation (Pearson’s co-efficient).

https://doi.org/10.1371/journal.pone.0261546.g005

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