Sativa Vs. Indica Vs. Hybrid: Chart, Different Use, Side Effects, More

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HealthlineSubscribeWhat to Know About the Differences Between Sativa, Indica, and Hybrid Strains of Weed

Medically reviewed by Alex Nguyen, PharmD, RPh, CPh — Written by Kimberly Holland — Updated on February 26, 2025

Cannabinoids and terpenes
Sativa
Indica
Hybrid
Ruderalis
Risks
Strain chart
How to choose
Legality
Takeaway

Instead of looking at the cannabis type alone — like sativa, indica, or hybrid — look at the description the grower and dispensary provide.

More and more, the cannabis industry is moving away from the term “strains” and using chemovars (chemical varieties), since the word “strain” is often used to refer to bacteria and viruses.

Chemical varieties include:

Type I: High THC
Type II: THC/CBD combined
Type III: High CBD

In other words, the category or type of cannabis may not be the greatest indicator of the effects you’ll experience.

What to look for to understand the potential effects

The often-applied rule of thumb is that sativa is more invigorating and energizing, while indica is more relaxing and calming — but it’s not that simple.

Individual plants produce varying effects, even among the same type of cannabis. It all depends on the plant’s chemical composition and the growing technique used.

Cannabinoids

Cannabis plants contain dozens of chemical compounds called cannabinoids. These naturally occurring components are responsible for producing many of the effects — both negative and positive — of cannabis use.

Researchers still don’t understand what all of the cannabinoids do, but they have identified two main ones: tetrahydrocannabinol (THC) and cannabidiol (CBD).

Less common compounds include:

Cannabinol (CBN): CBN is used to ease symptoms and side effects of some neurological conditions.
Tetrahydrocannabinol acid (THCA): This is similar to THC but has no psychoactive effects.
Cannabigerol (CBG): CBG is thought to help reduce anxiety and symptoms of obsessive-compulsive disorder, post-traumatic stress disorder, and depression.

Terpenes

A great deal of attention is paid to the amount of THC and CBD in a given type of cannabis, but research suggests that terpenes may be just as impactful.

Terpenes are other naturally occurring compounds in the cannabis plant that may influence the effects that specific types produce.

Sativa in-depth

Cannabis sativa leaf — GoodLifeStudio/Getty Images

Origin: Cannabis sativa is found primarily in hot, dry climates with long sunny days. These include Africa, Central America, Southeast Asia, and portions of Western Asia.
Plant description: Sativa plants are tall and thin with finger-like leaves. They can grow to about 6 feet (ft) or 2 meters (m). They take longer to mature than some other types of cannabis.
Typical CBD-to-THC ratio: Sativa often has lower doses of CBD and higher doses of THC, whereas indica tends to have less THC than CBD.
Commonly associated effects of use: Sativa often produces a “mind high” or an energizing, anxiety-reducing effect.
Daytime or nighttime use: Because of its stimulating effects, sativa is often used in the daytime.

Indica in-depth

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Origin: Cannabis indica is native to Afghanistan, India, Pakistan, and Turkey. The plants have adapted to the often harsh, dry, and turbulent climate of the Hindu Kush mountains.
Plant description: Indica plants are short and stocky with bushy greenery and chunky leaves that grow wide and broad. They grow faster than sativa, and each plant produces more buds.
Typical CBD-to-THC ratio: Indica strains often have higher levels of CBD, but the THC content isn’t necessarily less.
Commonly associated effects of use: Indica is sought after for its intensely relaxing effects. It may also help reduce nausea and pain and increase appetite.
Daytime or nighttime use: Because of its deep relaxation effects, indica is typically consumed at night.

Hybrid in-depth

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Each year, cannabis growers produce new and unique strains from different combinations of parent plants. These cannabis hybrids are often grown to target specific effects.

Origin: Hybrids are typically grown on farms or in greenhouses from a combination of sativa and indica plants.
Plant description: The appearance of hybrid strains depends on the combination of the parent plants.
Typical CBD-to-THC ratio: Many hybrid cannabis plants are grown to increase the THC percentage, but each type has a unique ratio of the two cannabinoids.
Commonly associated effects of use: Farmers and producers select hybrids for their unique effects. They can range from reducing anxiety and stress to easing symptoms of chemotherapy or radiation.
Daytime or nighttime use: This depends on the hybrid’s predominant effects. Hybrids are typically classified as indica-dominant (indica-dom), sativa-dominant (sativa-dom), or balanced.

Ruderalis in-depth

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On its own, Cannabis ruderalis isn’t a popular cannabis option. However, cannabis farmers may breed ruderalis with other cannabis types, including sativa and indica.

The plant’s rapid growth cycle is a positive attribute for producers, so they may want to combine more potent strains with ruderalis to create a more desirable product.

Origin: Ruderalis plants adapt to extreme environments, such as Eastern Europe, the Himalayan regions of India, Siberia, and Russia. These plants grow quickly, which is ideal for the cold, low-sunlight environments of these places.
Plant description: These small, bushy plants rarely grow taller than 12 inches (in), but they grow rapidly. One can go from seed to harvest in little more than a month.
Typical CBD-to-THC ratio: This strain typically has little THC and higher amounts of CBD, but it may not be enough to produce any effects.
Commonly associated effects of use: Because of its low potency, ruderalis isn’t routinely used for medicinal or recreational purposes.
Daytime or nighttime use: This cannabis plant produces few effects, so it can be used anytime.

Potential side effects and risks

Although cannabis use is often associated with potential benefits, it can also produce unwanted side effects.

Most of these effects are associated with THC, not CBD or other cannabinoids. However, any cannabis product can produce side effects.

The method of use may increase the risk of side effects, too. For example, smoking or vaping cannabis can irritate your lungs and airways. This may lead to coughing and increase your risk of respiratory conditions.

Oral cannabis preparations, such as gummies or cookies, are less likely to affect your overall respiratory health.

However, though the effects are felt more slowly, ingested cannabis, especially THC, is more potent as it converts to 11-hydroxy-THC, which produces stronger psychoactive effects that can last for hours and, in some people, days.

Common strains to consider for certain conditions

The potency of cannabinoids and terpenes varies among growers, and while certain strains may be helpful for certain conditions, your own experience may vary.

Strain	Category	CBD	THC	Conditions
Acapulco Gold	sativa	0.11%	15–23%	• fatigue• stress• nausea• pain
Blue Dream	hybrid	1%	about 30%	• pain• cramps• inflammation• insomnia• mental fog• PTSD
Purple OG Kush	indica	less than 0.1%	19%	• chronic pain• muscle spasms• insomnia
Sour Diesel	hybrid	less than 0.1%	about 31%	• fatigue• stress• acute pain• mental fog• anxiety• PTSD
Bubba Kush	indica	less than 0.1%	14–25%	• insomnia• acute pain• nausea• low appetite• PTSD
Granddaddy Purple	hybrid	0.1%	17–23%	• low appetite• restless leg syndrome• insomnia
Afghan Kush	indica	less than 0.1%	13–17%	• acute pain• insomnia• low appetite
LA Confidential	indica	0.3%	16–20%	• inflammation• pain• stress
Maui Waui	sativa	0.55%	13–19%	• fatigue• depression
Golden Goat	hybrid	1%	23%	• depression• anxiety• mental fog• low energy
Northern Lights	indica	0.1%	16%	• pain• mood disorders• insomnia• low appetite
White Widow	hybrid	1%	12–20%	• low mood• mental fog• social anxiety
Super Silver Haze	hybrid	0.03%	16%	• stress• anxiety• mental fog• low energy
Pineapple Express	hybrid	less than 0.1%	about 23%	• mental fog• acute pain• social anxiety
Supernatural	hybrid	1%	22%	• migraine• glaucoma• headache• low mood

How to choose the right cannabis product for you

Talk with the dispensary employee about your goals for cannabis use, whether that’s treating insomnia, reducing anxiety, or increasing energy.

Some strains are considered “entry level.” Their effects are typically mild and tolerable. Strains with higher levels of cannabinoids may be too potent for a first-time user.

It’s important to know your tolerance level, as well as your medical history, in case of potential interactions with other drugs.

Each technique for consuming cannabis has benefits and drawbacks. If you smoke or vape cannabis, you may feel the effects more quickly, but it can irritate your lungs and airways.

Gummies, chewables, and other edibles may be easier to tolerate, but the effects take longer. They may also be much more potent than inhalation.

Cannabis legality varies from state to state

Cannabis isn’t legal everywhere. A few years ago, all cannabis products were illegal in most parts of the United States. Today, many states have legalized cannabis for medical or recreational purposes or both.

CBD laws are also evolving. Some states allow it for medicinal purposes, but they heavily regulate the source to prevent THC-laced CBD products.

Before you attempt to purchase or use cannabis, know the laws in your state.

Keep in mind that cannabis is still illegal under federal law. If you don’t know the laws where you are, you could face legal consequences.

You may be subject to different laws if you live outside the United States.

The bottom line

If you’re curious how cannabis might help you, talk with a doctor or other qualified healthcare professional, or speak with a knowledgeable cannabis clinician.

They can discuss its potential positive and negative effects on your individual health and help you find something that suits your needs.

Then, you can begin to explore your options. Finding the right option for you may take time. You may also find that you don’t tolerate cannabis well.

If you live in a state that has legalized cannabis, you can visit a dispensary and talk with a trained staff member. They may be able to recommend specific strains or other products to suit your individual needs.

How we reviewed this article:

SourcesHistoryHealthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical journals and associations. We only use quality, credible sources to ensure content accuracy and integrity. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.

Anderson PJ, et al. (2021). How to identify hemp, Cannabis sativa L. (and lookalike) plants.https://www.fdacs.gov/ezs3download/download/96962/2651285/Media/Files/Plant-Industry-Files/CIRCULAR-Hemp-01945.pdf
Barcaccia G, et al. (2020). Potentials and challenges of genomics for breeding cannabis cultivars.https://www.frontiersin.org/articles/10.3389/fpls.2020.573299/full
Hanus LO, et al. (2020). Terpenes/terpenoids in Cannabis: Are they important?https://karger.com/mca/article/3/1/25/188913/Terpenes-Terpenoids-in-Cannabis-Are-They-Important
Kaplan AG. (2021). Cannabis and lung health: Does the bad outweigh the good?https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589923/
McPartland JM. (2018). Cannabis systematics at the levels of family, genus, and species.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225593/
Sommano SR, et al. (2020). The cannabis terpenes.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763918/

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Medically reviewed by Alex Nguyen, PharmD, RPh, CPh — Written by Kimberly Holland — Updated on February 26, 2025

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What to look for to understand the potential effects

Cannabinoids

Terpenes

Sativa in-depth

Indica in-depth

Hybrid in-depth

Ruderalis in-depth

Potential side effects and risks

Common strains to consider for certain conditions

How to choose the right cannabis product for you

Cannabis legality varies from state to state

The bottom line

How we reviewed this article:

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