C 021 Dihydrochloride | CAS 1784252-84-1 | SCBT

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C 021 dihydrochloride (CAS 1784252-84-1) - chemical structure image
Molecular structure of C 021 dihydrochloride, CAS Number: 1784252-84-1
C 021 dihydrochloride (CAS 1784252-84-1) - chemical structure image
Molecular structure of C 021 dihydrochloride, CAS Number: 1784252-84-1
Molecular structure of C 021 dihydrochloride, CAS Number: 1784252-84-1C 021 dihydrochloride (CAS 1784252-84-1)0.0(0)Write a reviewAsk a questionAlternate Names:2-[1,4′-Bipiperidin]-1′-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinamine dihydrochlorideCAS Number:1784252-84-1Purity:≥99%Molecular Weight:540.57Molecular Formula:C27H41N5O2•2HClFor Research Use Only. Not Intended for Diagnostic or Therapeutic Use. Available in US only.* Refer to Certificate of Analysis for lot specific data.

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Ordering InformationDescriptionTechnical InformationSafety InformationSDS & Certificate of AnalysisDescriptionTechnical InformationSafety InformationSDS & Certificate of Analysis

A potent CCR4 chemokine receptor antagonist (IC50 values are 0.14 and 0.039 μM for inhibition of chemotaxis in human and mouse respectively)

C 021 dihydrochloride (CAS 1784252-84-1) References

Yokoyama et al (2009) Potent and orally bioavailable CCR4 antagonists: synthesis and structure-activity relationship study of 2-aminoquinazolines. Bioorg.Med.Chem. 17 64.

Inhibitor of:CKR-4.

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Physical State :

Solid

Solubility :

Soluble in water (50 mM), and DMSO (100 mM).

Storage :

Desiccate at room temperature

IC50 :

CCR4 chemokine receptor: IC50 = 0.14 µM (human); CCR4 chemokine receptor: IC50 = 0.039 µM (mouse); CCL22-binding: IC50 = 73 nM; CCL22-induced GTPγS recruitment: IC50 = 18 nM

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use. Available in US only.

Transport :

Not available for sale outside of the United States.

PubChem CID :

56972238

MDL Number :

MFCD16618393

SMILES :

COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCC(CC3)N4CCCCC4)NC5CCCCCC5)OC.Cl.Cl

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Region

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SAMPLE Certificate of Analysis (COA)

C 021 dihydrochloride | CAS 1784252-84-1 SAMPLE Certificate of Analysis

Certificate of Analysis

Catalog Number

sc-293973sc-293973A

Lot Number

SUBMIT

SAMPLE Certificate of Analysis (COA)

Catalog Number:sc-293973Lot Number:SAMPLEProduct Name:C 021 dihydrochlorideMolecular Formula:C27H41N5O2•2HClMolecular Weight:540.57
TestSpecificationResults
AppearancePale yellow solid
Identification (1H-NMR)Consistent with structure
Identification (Mass Spectrometry)Consistent with structure
Purity (HPLC)99.6%
TLCRf = 0.4 (Dichloromethane: Methanol [4: 1])
Carbon Content58.06%58.09%
Hydrogen Content8.12%8.13%
Nitrogen Content12.54%12.51%

TEST CONDITIONS

Exp. Date: 9/4/2024

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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

C 021 dihydrochloride, 10 mg

sc-29397310 mg$210.00-+ADD TO CART
US: Only available in the US

C 021 dihydrochloride, 50 mg

sc-293973A50 mg$880.00-+ADD TO CART
US: Only available in the US
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