C-021 Dihydrochloride | CCR4 Antagonist - MedChemExpress

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1. GPCR/G Protein Immunology/Inflammation
2. CCR
3. C-021 dihydrochloride

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C-021 dihydrochloride is a potent CC chemokine receptor-4 (CCR4) antagonist. C-021 dihydrochloride potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM, respectively. C-021 dihydrochloride effectively prevents human CCL22-derived [35S]GTPγS from binding to the receptor with an IC50 of 18 nM.

For research use only. We do not sell to patients.

C-021 dihydrochloride Chemical Structure

CAS No. : 1784252-84-1

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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of C-021 dihydrochloride:

• C-021 In-stock
• C-021 dihydrochloride (Standard) Get quote

C-021 dihydrochloride Related Antibodies

2 Publications Citing Use of MCE C-021 dihydrochloride

• •J Immunother Cancer. 2024 Dec 4;12(12):e009629. [Abstract]
• •Biochem Pharmacol. 2023 Apr:210:115475. [Abstract]

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View All CCR Isoform Specific Products:

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• Customer Review

• [1]. Yokoyama K, et al. Potent and orally bioavailable CCR4 antagonists: Synthesis and structure-activity relationship study of 2-aminoquinazolines. Bioorg Med Chem. 2009 Jan 1;17(1):64-73.

  [2]. Matthew McMillin, et al. Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline. J Neuroinflammation. 2014 Jul 10;11:121.

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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C-021 dihydrochloride Related Classifications

• Disease Areas
• Inflammation or Immune System Disease Digestive System Disease Respiratory Disease Musculoskeletal Disease Cancer
• Pulmonary Disease Autoimmune Disease Arthritis Digestive System Inflammation
• Lung Fibrosis Rheumatoid Arthritis

• Inflammation/Immunology

• GPCR/G Protein Immunology/Inflammation
• CCR

• Do most proteins show cross-species activity?

  Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

C-0211784252-84-1C021C 021CCRCC chemokine receptorCCR4CCL22GTPγSchemotaxisInhibitorinhibitorinhibit

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