Top 14+ Cb 839 hay nhất
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1.Telaglenastat (CB-839) - Glutaminase Inhibitor
Biological Activity ; Telaglenastat (CB-839) is a potent, selective, and orally bioavailable glutaminase inhibitor with IC50 of 24 nM for recombinant human GAC.
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2.Study Of CB-839 (Telaglenastat) In Combination With Talazoparib In ...
800 mg CB-839 taken twice daily and 1 mg talazoparib taken once daily in participants with incurable/locally advanced or metastatic triple-negative breast ...
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3.The Glutaminase Inhibitor CB-839 (Telaglenastat) Enhances The ...
CB-839 treatment decreased the conversion of glutamine to alpha-ketoglutarate (αKGA) more potently in tumor cells versus TILs in these cocultures. These results ...
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4.Antitumor Activity Of The Glutaminase Inhibitor CB-839 In ... - PubMed
CB-839 had antiproliferative activity in a triple-negative breast cancer (TNBC) cell line, HCC-1806, that was associated with a marked decrease in glutamine ...
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5.CB-839, A Glutaminase Inhibitor, In Combination With Cabozantinib In ...
26 Feb 2019 · CB-839 is a first-in-clinic, small molecule, reversible, oral GLS inhibitor that synergizes with cabozantinib (Cabo), a VEGFR2/MET/AXL inhibitor ...
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6.A Phase Ib Trial Of CB-839 (telaglenastat) In Combination With ...
26 May 2019 · This defect causes these tumors to become more reliant on glutaminase for glutamate biosynthesis from glutamine. CB-839 (telaglenastat) is a ...
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7.Antitumor Activity Of The Glutaminase Inhibitor CB-839 In Triple ...
CB-839 (Fig. 1A) is a novel glutaminase inhibitor that exhibits low nanomolar potency in biochemical and cellular assays and has good oral bioavailability. In a ...
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8.CB 839 Supplier | CAS 1439399-58-2 | CB839 - Tocris Bioscience
CB 839 is a potent non-competitive glutaminase (GLS1) inhibitor (IC50 = 24 nM for recombinant human GAC). The compound exhibits selectivity for GLS1 over ...
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9.[PDF] FOR CONDUCTING CLINICAL TRIALS USING CB-839 ... - DF/HCC
CB-839 has antineoplastic and pro-apoptotic activity in a variety of human tumor cell lines, including triple-negative breast cancer (TNBC), clear cell ...
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10.Metabolomic, Proteomic And Genomic Profiling Identifies ...
3 Dec 2015 · Selective glutaminase inhibitors BPTES and CB-839 have anti-proliferative activity in several pre-clinical cancer models including breast, ...
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11.Telaglenastat (CB-839) | GLS1 Inhibitor - MedChemExpress
Telaglenastat (CB-839) is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat selectively inhibits GLS1 ...
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12.GLS1 Inhibitor III, CB-839 - CAS 1439399-58-2 - Calbiochem
GLS1 Inhibitor III, CB-839 - CAS 1439399-58-2 - Calbiochem · Cell-permeable, orally available, potent, selective & non-competitive GLS1 inhibitor. Reduces ...
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13.CB 839 (CAS 1439399-58-2) - R&D Systems
CB 839 ; Description: Potent glutaminase GLS1 inhibitor ; Biological Activity. CB 839 is a potent non-competitive glutaminase (GLS1) inhibitor (IC50 = 24 nM for ...
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14.Glutaminase Inhibitor CB-839 Increases Radiation Sensitivity Of Lung ...
Since our previous work, several novel GLS inhibitors became available and we report herein effects of CB-839 in A427, H460 and A549 lung tumor cells and ...
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