CC-115 Hydrochloride | DNA-PK/mTOR Inhibitor - MedChemExpress

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1. Cell Cycle/DNA Damage PI3K/Akt/mTOR
2. DNA-PK mTOR
3. CC-115 hydrochloride

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Help & FAQs

CC-115 hydrochloride is a potent and dual DNA-PK and mTOR kinase inhibitor with IC50s of 13 nM and 21 nM, respectively. CC-115 blocks both mTORC1 and mTORC2 signaling.

For research use only. We do not sell to patients.

CC-115 hydrochloride Chemical Structure

CAS No. : 1300118-55-1

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of CC-115 hydrochloride:

• CC-115 In-stock

CC-115 hydrochloride Related Antibodies

2 Publications Citing Use of MCE CC-115 hydrochloride

• •Sci Data. 2024 Sep 19;11(1):1024.
• •Front Pharmacol. 2020 Nov 11;11:580407. [Abstract]

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•Related Small Molecules:

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View All mTOR Isoform Specific Products:

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• Customer Review

• [1]. Mortensen DS, et al. Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115. J Med Chem. 2015 Jul 23;58(14):5599-5608.

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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CC-115 hydrochloride Related Classifications

• Disease Areas
• Cancer Neurological, Eye or Ear Disease Blood or Cardiovascular Disease Metabolic or Endocrine Disease Respiratory Disease Digestive System Disease Urogenital Disease
• Blood Disease Lipid Metabolism Pulmonary Disease Lung Cancer Breast Cancer Colorectal Cancer Digestive System Cancer Prostate Cancer Urogenital Cancer Gastric Cancer Liver Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Ovarian Cancer Pain
• Leukemia/Lymphoma/Myeloma Obesity Lung Fibrosis

• Cancer
• Cancer Targeted Therapy Cancer Metabolism and Metastasis

• Cell Cycle/DNA Damage PI3K/Akt/mTOR
• DNA-PK mTOR

• Do most proteins show cross-species activity?

  Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CC-1151300118-55-1CC115CC 115DNA-PKmTORDNA-dependent protein kinaseMammalian target of RapamycinInhibitorinhibitorinhibit

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