Clinical Significance Of 8q24/c-MYC Translocation In Diffuse Large B ...

Clipboard, Search History, and several other advanced features are temporarily unavailable. Skip to main page content

The .gov means it’s official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation Search: Search Advanced Clipboard Save Email Send to

• Clipboard
• My Bibliography
• Collections
• Citation manager

Display options Display options Format Abstract PubMed PMID

Save citation to file

Format: Summary (text) PubMed PMID Abstract (text) CSV Create file Cancel

Email citation

Email address has not been verified. Go to My NCBI account settings to confirm your email and then refresh this page. To: Subject: Body: Format: Summary Summary (text) Abstract Abstract (text) MeSH and other data Send email Cancel

Add to Collections

• Create a new collection
• Add to an existing collection

Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error Please try again Add Cancel

Add to My Bibliography

• My Bibliography

Unable to load your delegates due to an error Please try again Add Cancel

Your saved search

Name of saved search: Search terms: Test search terms Would you like email updates of new search results? Saved Search Alert Radio Buttons

• Yes
• No

Email: (change) Frequency: Monthly Weekly Daily Which day? The first Sunday The first Monday The first Tuesday The first Wednesday The first Thursday The first Friday The first Saturday The first day The first weekday Which day? Sunday Monday Tuesday Wednesday Thursday Friday Saturday Report format: Summary Summary (text) Abstract Abstract (text) PubMed Send at most: 1 item 5 items 10 items 20 items 50 items 100 items 200 items Send even when there aren't any new results Optional text in email: Save Cancel

Create a file for external citation management software

Create file Cancel

Your RSS Feed

Name of RSS Feed: Number of items displayed: 5 10 15 20 50 100 Create RSS Cancel RSS Link Copy

Full text links

Wiley Free PMC article Full text links

Actions

CiteCollectionsAdd to Collections

• Create a new collection
• Add to an existing collection

Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an errorPlease try again Add Cancel PermalinkPermalinkCopyDisplay options Display options Format AbstractPubMedPMID

Page navigation

• Title & authors
• Abstract
• Figures
• References
• MeSH terms
• Substances
• LinkOut - more resources

Title & authors Abstract Figures References MeSH terms Substances LinkOut - more resources Full text links CiteDisplay options Display options Format AbstractPubMedPMID

Abstract

Diffuse large B-cell lymphoma (DLBCL) has heterogeneous clinical, histological, and molecular features. We evaluated the clinical characteristics and prognoses of patients with DLBCL carrying 8q24 translocations. A total of 1864 consecutive patients with non-Hodgkin's lymphoma were treated in the Adult Lymphoma Treatment Study Group from 1998 to 2005. Of the 252 patients with DLBCL with abnormal karyotypes, 28 patients with DLBCL with the 8q24 translocation were identified. There were 14 men and 14 women, with a median age of 61 years. The 8q24 translocation was observed significantly more frequently among patients with poor performance status, among patients with high lactate dehydrogenase level, and among patients with bone marrow involvement. The 5-year overall survival was 43.9% among the patients with 8q24 translocation, and 67% among the patients with other chromosomal abnormalities. The 8q24 translocation group showed significantly poorer prognosis than the group with other translocations. In addition, patients with t(14;18) and 8q24 translocation showed significantly poorer prognosis than those with 8q24 translocation alone. It will be necessary to study whether more aggressive chemotherapy or rituximab combination chemotherapy is effective in 8q24 translocation cases.

PubMed Disclaimer

Figures

Figure 1

(a) Overall and (b) progression‐free…

Figure 1

(a) Overall and (b) progression‐free survival curves of patients with diffuse large B‐cell…

Figure 2

(a) Overall and (b) progression‐free…

Figure 2

(a) Overall and (b) progression‐free survival curves of patients with diffuse large B‐cell…

Figure 3

(a) Overall and (b) progression‐free…

Figure 3

(a) Overall and (b) progression‐free survival curves of patients with diffuse large B‐cell…

See this image and copyright information in PMC

References

1. 1. Shipp MA. International non‐Hodgkin's lymphoma prognostic factors project. A predictive model for aggressive non‐Hodgkin's lymphoma. N Engl J Med 1993; 329: 987–94. - PubMed
2. 1. Vega F, Medeiros LJ. Chromosomal translocations involved in non‐Hodgkin lymphomas. Arch Pathol Lab Med 2003; 127: 1148–60. - PubMed
3. 1. Au WY, Horsman DE, Gascoyne RD, Viswanatha DS, Klasa RJ, Connors JM. The spectrum of lymphoma with 8q24 aberrations: a clinical, pathological and cytogenetic study of 87 consecutive cases. Leuk Lymphoma 2004; 45: 519–28. - PubMed
4. 1. Niitsu N, Okamoto M, Aoki S, Kuraishi Y, Okumura H, Hirano M. Multicenter phase II study of the CyclOBEAP (CHOP‐like + etoposide and bleomycin) regimen for patients with poor‐prognosis aggressive lymphoma. Ann Haematol 2006; 85: 374–80. - PubMed
5. 1. Sánchez‐Beato M, Sánchez‐Aguilera A, Piris MA. Cell cycle deregulation in B‐cell lymphomas. Blood 2003; 101: 1220–35. - PubMed

Show all 16 references

MeSH terms

• Adult Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Aged Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Aged, 80 and over Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Chromosome Aberrations Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Chromosomes, Human, Pair 8 / genetics* Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Female Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Humans Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Lymphoma, Large B-Cell, Diffuse / genetics* Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Lymphoma, Large B-Cell, Diffuse / pathology Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Male Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Middle Aged Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Prognosis Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Proto-Oncogene Proteins c-myc / genetics* Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Survival Rate Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Translocation, Genetic / genetics* Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search

Substances

• MYC protein, human Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Proto-Oncogene Proteins c-myc Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search

LinkOut - more resources

• Full Text Sources

  • Europe PubMed Central
  • Ovid Technologies, Inc.
  • PubMed Central
  • Wiley

• Research Materials

  • NCI CPTC Antibody Characterization Program

Full text links [x] Wiley Free PMC article [x] Cite Copy Download .nbib .nbib Format: AMA APA MLA NLM Send To

• Clipboard
• Email
• Save
• My Bibliography
• Collections
• Citation Manager

[x]

NCBI Literature Resources

MeSH PMC Bookshelf Disclaimer

The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.