MYC (8q24) Break Apart FISH Probe Orange/Green - Biocare Medical

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MYC (8q24) Break Apart FISH Probe Orange/Green SKU: PFR7026A Categories: FISH, FISH Probes, PathoFISH™ Tags: 7026, PFR 7026, PFR 7026A, PFR7026, PFR7026A

Description

Product Description

The MYC (8q24) Break Apart FISH probe is designed to detect chromosomal rearrangements involving the MYC gene on Chromosome 8q24. The MYC gene belongs to a family of transcription factors and under normal conditions it controls cell cycle progression1. However in multiple cancer indications, MYC is considered a Proto-oncogene1. MYC gene deregulation is identified in multiple malignancies such as Burkitt’s lymphoma, diffuse large B-cell lymphoma, and B-cell lymphoma2. MYC gene amplifications, rearrangements, and/or point mutations are considered the underlining mechanisms that induce MYC gene deregulation1. Specifically, a MYC gene rearrangement is considered a prognostic marker in several cancer subtypes. MYC gene rearrangements can be identified using conventional cytogenetic techniques such as fluorescence in situ hybridization (FISH).

Specifications

Specifications

Intended Use	RUO
Volume	100 µl
Target	Breast, Cervical, CLL, Esophogeal, Gastric, Lymphoma, Prostate
Color	Green, Orange
Chromosome	8

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