CMR Classification / Work With CMR Substances - Security Information

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Laboratory Safety Manual

CMR classification / work with CMR substances

The rules that apply to CMR substances are set out on the Swedish Work Environment Authority’s website on substances that are carcinogenic, mutagenic or toxic to reproduction, Sections 38-49.

Substances that are carcinogenic, mutagenic or toxic to reproduction (CMRs) may only be handled if a documented study shows that it is not technically possible to replace the product with other chemical products that are less harmful and thus present less risk. This study must be enclosed along with the results of the risk assessment that just be performed before starting the work. Employees exposed to levels of carcinogenic and mutagenic substances that pose a health risk must be recorded in a register (the activity manager is responsible for the compilation of the register), and the data must be stored for 40 years.

CMR classified substances are products with the following hazard statements

Under the CLP Regulation (EC) No 1272/2008, CMR classified substances are classified with the following hazard statements:

• H350: May cause cancer
• H340: May cause genetic defects
• H360: May damage fertility or the unborn child

These hazard statements replace the previous risk phrases:

• R45: May cause cancer; R46: May cause heritable genetic damage; R49: May cause cancer by inhalation; R60: May impair fertility; R61: May cause harm to the unborn child

Risk assessment of work with CMR substances

The following information must be included in the risk assessment documentation:

1. The locations and areas where the substance may be present, and the measures taken to ensure that only persons who are needed for the work are present in these locations.
2. The safety measures necessary in order to minimise exposure.
3. The personal protective equipment required, and in what situations it is needed.
4. How the handling and function of equipment, processes or ventilation should be monitored to enable early detection of irregularities that may lead to an increased risk.