23 thg 7, 2021 · CX-072 (pacmilimab) is a Probody therapeutic directed against PD-L1. In preclinical studies, pacmilimab induced antitumor responses ...
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23 thg 7, 2021 · PROCLAIM-CX-072 (PRObody CLinical Assessment In Man, CX-072 Clinical Trial 001) is a first-in-human study evaluating the tolerability, and ...
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CX-072 (pacmilimab), a Probody PD-L1 inhibitor, in combination with ipilimumab in patients with advanced solid tumors (PROCLAIM-CX-072): a first-in-human, dose- ...
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CX-072 (pacmilimab), a Probody ® PD-L1 inhibitor, in advanced or recurrent solid tumors (PROCLAIM-CX-072): an open-label dose-finding and first-in-human study.
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25 thg 5, 2020 · CX-072 is an investigational PD-L1 PROBODY therapeutic that is preferentially activated in the tumor microenvironment (TME); localized ...
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CX-072 is a Probody™ therapeutic directed against PD-L1 (programmed cell death ligand 1). Probody therapeutics are proteolytically-activatable antibodies (Abs) ...
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PROCLAIM: CX-072-002: Study of PD-L1 Probody Therapeutic CX-072 in Combination With Other Anticancer Therapy in Adults With Solid Tumors ...
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CX-072 is an anti–PD-L1 Probody™ therapeutic (Pb-Tx) designed to be preferentially activated by proteases in the tumor microenvironment and not in healthy ...
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Background: CX-072 is a novel protease activatable prodrug (Probody™ therapeutic) derived from a human monoclonal antibody against programmed cell death ligand ...
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CytomX and AbbVie are co-developing CX-2029, a conditionally activated antibody-drug conjugate (ADC) directed against CD71, the transferrin receptor that is ...
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An open-label, dose-finding and proof of concept study of the PD-L1 probody therapeutic, CX-072, as monotherapy and in combination with Yervoy® (Ipilimumab) ...
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Zr-CX-072 accumulates specifically in PD-L1–expressing tumors with limited uptake in murine peripheral lymphoid tissues. Our data may enable clinical evaluation ...
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Request PDF | PROCLAIM-CX-072: Analysis of patients with advanced solid tumors receiving long-term treatment with CX-072, a PD-L1 probody therapeutic, ...
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Purpose of trial The aim of this trial is to test whether CX-072 on its own or in combination with other treatments is safe and effective for people with ...
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