Pipeline - CytomX

Advancing our pipeline

Our expanding pipeline of Probody® therapeutics is built on a robust portfolio of proprietary and patented technology. Rooted in innovation and differentiation, and driven by our vision and mission, we are advancing a deep oncology pipeline of Probody therapeutics through our own bold science and partnerships with some of the world’s leading biopharmaceutical companies.

Research & development

Product Candidate Target Indication Preclinical Phase 1 Phase 2 Partner

Wholly-Owned or Retained US Rights*

❯ CX-2051 EpCAM Solid Tumors ❯ CX-801 IFN-α2b Solid Tumors Probody TCBs Undisclosed TBD

*U.S. Rights include wholly-owned molecules or collaboration molecules in which CytomX has a right or option to share in U.S. commercial profits

Fully Partnered Pipeline

Probody TCBs Undisclosed TBD Various Undisclosed TBD Various Undisclosed Oncology & Non-Oncology Probody® Modality: ADCs TCBs mRNA Immunotherapy Undisclosed

Lead candidates

We are utilizing our Probody® platform to develop potential best-in-class therapies against clinically validated targets and potential first-in-class therapeutics against novel, difficult-to-treat targets.

We believe our Probody therapeutics have the potential to:

• Create or widen therapeutic window – the balance between a therapy’s dose that is effective without causing unacceptable toxicity
• Enable new combinations of drugs previously not possible due to toxicities
• Expand the universe of viable therapeutic targets by opening “undruggable” target space
• Make new treatment options possible for more patients

CX-2051 (EpCAM-directed conditionally activated antibody-drug conjugate)

CX-2051 is a conditionally activated ADC directed toward the epithelial cell adhesion molecule (EpCAM), with potential applicability across multiple EpCAM-expressing epithelial cancers. EpCAM is a validated anti-cancer target for which systemic therapies not yet been developed due to widespread expression on normal tissues. CX-2051 is designed to open a therapeutic window for a systemically administered anti-EpCAM ADC. The drug candidate is currently in Phase 1a dose-escalation study in patients with advanced colorectal cancer; initial Phase 1a clinical data is expected in the first half of 2025.

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CX-801 (Interferon alpha-2b Probody cytokine)

CX-801 is a wholly-owned interferon (IFN) alpha-2b Probody® therapeutic. Interferons are approved anti-cancer therapies but are limited by narrow therapeutic windows. Based on preclinical studies, CX-801 demonstrated a wide therapeutic index with an enhanced tolerability profile versus unmasked IFN, without compromising its potent antitumor effects. CX-801 has broad potential applicability in traditionally immuno-oncology sensitive as well as insensitive (cold) tumors. The drug candidate is currently in Phase 1a dose-escalation study in patients with metastatic melanoma; initial Phase 1a translational and biomarker data is expected in the second half of 2025.

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Clinical trials

Two of our drug candidates are currently in clinical trials, investigating their potential utility in advanced or recurrent cancers.

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Access information for healthcare providers & patients

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