Dai Et Al., 2016 - ZFIN Publication

• Dai et al., 2016 ZDB-PUB-161025-44 PMID:27751705

• Summary
• Abstract
• Genes / Markers
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• Mutations / Transgenics
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PUBLICATION Cebpα is essential for the embryonic myeloid progenitor and neutrophil maintenance in zebrafish Authors Dai, Y., Zhu, L., Huang, Z., Zhou, M., Jin, W., Liu, W., Xu, M., Yu, T., Zhang, Y., Wen, Z., Liao, W., Zhang, W. ID ZDB-PUB-161025-44 Date 2016 Source Journal of genetics and genomics = Yi chuan xue bao 43(10): 593-600 (Journal) Generate reference Registered Authors Huang, Zhibin, Liu, Wei, Wen, Zilong, Xu, Mengchang, Zhang, Wenqing, Zhang, Yiyue Keywords Cebpα, Development, Embryonic myelopoiesis, Zebrafish MeSH Terms

• Mutation
• Embryo, Nonmammalian/cytology*
• Embryo, Nonmammalian/metabolism
• CCAAT-Enhancer-Binding Proteins/metabolism*
• Cell Cycle Checkpoints/genetics
• Base Sequence
• Animals
• Neutrophils/cytology*
• Myeloid Progenitor Cells/cytology*
• Exons/genetics
• Zebrafish/embryology*
• Zebrafish/genetics
• Zebrafish/metabolism*
• Macrophages/cytology
• Myelopoiesis

PubMed 27751705 Full text @ J. Genet. Genomics Citation Dai, Y., Zhu, L., Huang, Z., Zhou, M., Jin, W., Liu, W., Xu, M., Yu, T., Zhang, Y., Wen, Z., Liao, W., Zhang, W. (2016) Cebpα is essential for the embryonic myeloid progenitor and neutrophil maintenance in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 43(10):593-600. Abstract In vertebrates, myeloid cells arise from multiple waves of development: the first or embryonic wave of myelopoiesis initiates early from non-hematopoietic stem cell (HSC) precursors and gives rise to myeloid cells transiently during early development; whereas the second or adult wave of myelopoiesis emerges later from HSCs and produces myeloid cells continually during fetal and adult life. In the past decades, a great deal has been learnt about the development of myeloid cells from adult myelopoiesis, yet the genetic network governing embryonic myelopoiesis remains poorly defined. In this report, we present an in vivo study to delineate the role of Cebpα during zebrafish embryonic myelopoiesis. We show that embryonic myelopoiesis in cebpα-deficient zebrafish mutants initiates properly but fails to produce macrophages and neutrophils. The lack of macrophages and neutrophils in the mutants is largely attributed to the cell cycle arrest of embryonic myeloid progenitors, resulting in the impairment of their maintenance and subsequent differentiation. We further show that Cebpα, perhaps acting cooperatively with Runx1, plays a critical role in embryonic neutrophil maintenance. Our findings reveal a new role of Cebpα in embryonic myelopoiesis. Genes / Markers Figures Show all Figures Expression Phenotype Mutations / Transgenics Human Disease / Model Sequence Targeting Reagents Fish Antibodies Orthology Engineered Foreign Genes Mapping Your Input Welcome Your Input Welcome We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly. Please check the highlighted fields and try again. Name: Institution: Email address: Please leave blank: Subject: Comments: Send your comments Thank you for submitting comments. Your input has been emailed to ZFIN curators who may contact you if additional information is required. Oops. Something went wrong. Please try again later.