G0-C14 - The chemical structure of PLGA-PEG/G0-C14 nanoparticles was studied.The particles are composed of three parts:outer peg surface,PLGA/G0-C14 layer ...
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This trilayer particle comprises three compartments: an PEG shell, a PLGA/G0-C14 layer, and an amphiphilic core containing siRNA. (B, C) Synthesis of the ...
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28 thg 10, 2013 · The G0-C14 compound is synthesized with cationic head groups that can efficiently bind siRNA via electrostatic interactions and flexible ... Significance · Abstract · Results and Discussion · Summary
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26 thg 4, 2019 · G0-C14 was used for mRNA complexation, and PLGA, a widely clinically used biodegradable and biocompatible polymer, was used to make a stable NP ...
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8 thg 6, 2015 · With G0-C14 as the cationic lipid component, the hybrid NP was ∼100 nm in size (Fig. 1B), with siRNA encapsulation efficiency at ∼80% and a ...
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23 thg 6, 2015 · cationic lipids (e.g., G0-C14) into small nanocomplexes with a size of ... transfection with G0-C14 NPs (50 nM siRNA), whereas only.
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4 thg 2, 2022 · The cationic lipid termed G0-C14 is synthesized by a unique synthetic strategy involving effective ring-opening of 1,2-epoxytetradecane ...
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12 thg 4, 2018 · amphiphilic dendrimer (G0–C14) by a simple double emulsion-solvent evaporation technique. In contrast, the lipid hybrid nanoparticles formed ...
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Anti-Reverse Cap Analog [ARCA; 3´-O-Me-m7G(5')ppp(5')G> ... This procedure used the cationic lipid-like molecule G0-C14 for mRNA complexation, ...
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10 thg 7, 2020 · The carbohydrate-decorated polymer/G0-C14 exhibited strong entrapment of mRNA and pDNA with an encapsulation efficiency of above 95%. The ...
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Aqueous siRNA was first mixed with water-miscible organic solution containing cationic lipid-like compound G0-C14 and PLGA polymer.
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... made with a TME-pH responsive Meo-PEG-b-PPMEMA polymer and a cationic lipid-like compound G0–C14 for in vivo delivery of cytotoxic saporin and brea.
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22 thg 6, 2022 · a self-created cationic lipid-like molecule G0-C14 to enable efficient transmucosal delivery of siIL11. Noninvasive.
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accessory excipients, G0-C14 confers high accumulation and effective transfection of various RNA therapeutics in tumors26–29,.
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