Responsive Nanoplatform For Systemic Saporin Delivery And Effective ...

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From the journal:

Chemical Communications

A tumor microenvironment (TME)-responsive nanoplatform for systemic saporin delivery and effective breast cancer therapy†

Qian Shen,‡a Lei Xu,‡b Rong Li,*a Guang Wu,a Senlin Li,b Phei Er Saw,b Yusheng Zhou*ac and Xiaoding Xu *ab Author affiliations

* Corresponding authors

a Institute of Pharmacy & Pharmacology and the Second Affiliated Hospital, University of South China, Hengyang 421001, P. R. China E-mail: [email protected], [email protected]

b Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, P. R. China

c The Affiliated Nanhua Hospital, University of South China, Hengyang 421001, P. R. China E-mail: [email protected]

Abstract

Intracellular delivery of therapeutic proteins remains a challenge for the success of protein-mediated disease treatment. We herein develop a robust nanoplatform made with a TME-pH responsive Meo-PEG-b-PPMEMA polymer and a cationic lipid-like compound G0–C14 for in vivo delivery of cytotoxic saporin and breast cancer therapy. This nanoplatform could respond to a TME pH to rapidly release saporin/G0–C14 complexes, which could significantly improve the uptake of cytosolic saporin by tumor cells and subsequent endosomal escape, thereby leading to an effective inhibition of tumor growth.

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Article information

DOI https://doi.org/10.1039/D0CC07808E Article type Communication Submitted 30 Nov 2020 Accepted 01 Feb 2021 First published 01 Feb 2021

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Chem. Commun., 2021,57, 2563-2566 BibTex EndNote MEDLINE ProCite ReferenceManager RefWorks RIS

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A tumor microenvironment (TME)-responsive nanoplatform for systemic saporin delivery and effective breast cancer therapy

Q. Shen, L. Xu, R. Li, G. Wu, S. Li, P. E. Saw, Y. Zhou and X. Xu, Chem. Commun., 2021, 57, 2563 DOI: 10.1039/D0CC07808E

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Qian Shen Lei Xu Rong Li Guang Wu Senlin Li Phei Er Saw Yusheng Zhou Xiaoding Xu

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