Gene Group: HEAT SHOCK PROTEIN 70 CHAPERONES - FlyBase

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FlyBase in AWS Open Data FlyBase NIH Grant Terminated Previous Next FB2025_05 , released December 11, 2025 Open Close General Information Name HEAT SHOCK PROTEIN 70 CHAPERONES Species D. melanogaster Symbol HSP70 FlyBase ID FBgg0000497 Date last reviewed 2024-07-02 Number of members 13 Description Description The Heat Shock Protein 70 (Hsp70) superfamily of chaperones assist in numerous folding processes and are upregulated by heat stress and toxic chemicals. Hsp70 chaperones share a highly conserved bipartite domain structure composed of an ATPase domain and a substrate-binding domain. (Adapted from PMID:17441502, FBrf0232269 and FBrf0174945).Notes on Group

Kaneko (2022, FBrf0253513) has further classified D. mel Hsp70s into cytosolic A, cytosolic B, ER, and mitochondrial linages based on phylogenetic analysis.

Source Material The HEAT SHOCK PROTEIN 70 CHAPERONES Gene Group has been compiled using the following publication(s): Kaneko, 2022, Ratheesh et al., 2012, Takahashi et al., 2010, and Nikolaidis and Nei, 2004 . Key Gene Ontology (GO) terms Molecular FunctionATP-dependent protein folding chaperoneBiological Processresponse to heatCellular Component Related Gene Groups Parent group(s)ATP-DEPENDENT PROTEIN FOLDING CHAPERONESHEAT SHOCK PROTEINS Members (13) For all members: View Orthologs Export to HitList Export to Batch Download GO ribbon stack

molecular function	biological process	cellular component

×body Unable to display GO ribbon stack for gene groups with more than 100 members. External Data Equivalent Group(s) Human Heat shock 70kDa proteins (HGNC) Other resource(s)

[Heat shock protein information resource:Hsp70 ](http://pdslab.biochem.iisc.ernet.in/hspir/hsp70.php)

Synonyms and Secondary IDs Synonym(s) HSP70HEAT SHOCK PROTEIN 70 CHAPERONESHeat shock proteins 70kDa Secondary FlyBase ID(s) References (6)

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