Heat Shock Protein 70 KDa: Molecular Biology, Biochemistry, And ...

Clipboard, Search History, and several other advanced features are temporarily unavailable. Skip to main page content

The .gov means it’s official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation Search: Search Advanced Clipboard Save Email Send to

• Clipboard
• My Bibliography
• Collections
• Citation manager

Display options Display options Format Abstract PubMed PMID

Save citation to file

Format: Summary (text) PubMed PMID Abstract (text) CSV Create file Cancel

Email citation

Email address has not been verified. Go to My NCBI account settings to confirm your email and then refresh this page. To: Subject: Body: Format: Summary Summary (text) Abstract Abstract (text) MeSH and other data Send email Cancel

Add to Collections

• Create a new collection
• Add to an existing collection

Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error Please try again Add Cancel

Add to My Bibliography

• My Bibliography

Unable to load your delegates due to an error Please try again Add Cancel

Your saved search

Name of saved search: Search terms: Test search terms Would you like email updates of new search results? Saved Search Alert Radio Buttons

• Yes
• No

Email: (change) Frequency: Monthly Weekly Daily Which day? The first Sunday The first Monday The first Tuesday The first Wednesday The first Thursday The first Friday The first Saturday The first day The first weekday Which day? Sunday Monday Tuesday Wednesday Thursday Friday Saturday Report format: Summary Summary (text) Abstract Abstract (text) PubMed Send at most: 1 item 5 items 10 items 20 items 50 items 100 items 200 items Send even when there aren't any new results Optional text in email: Save Cancel

Create a file for external citation management software

Create file Cancel

Your RSS Feed

Name of RSS Feed: Number of items displayed: 5 10 15 20 50 100 Create RSS Cancel RSS Link Copy

Full text links

Elsevier Science Full text links

Actions

CiteCollectionsAdd to Collections

• Create a new collection
• Add to an existing collection

Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an errorPlease try again Add Cancel PermalinkPermalinkCopyDisplay options Display options Format AbstractPubMedPMID

Page navigation

• Title & authors
• Abstract
• Publication types
• MeSH terms
• Substances
• LinkOut - more resources

Title & authors Abstract Publication types MeSH terms Substances LinkOut - more resources Full text links CiteDisplay options Display options Format AbstractPubMedPMID

Abstract

Heat shock proteins (HSPs) are detected in all cells, prokaryotic and eukaryotic. In vivo and in vitro studies have shown that various stressors transiently increase production of HSPs as protection against harmful insults. Increased levels of HSPs occur after environmental stresses, infection, normal physiological processes, and gene transfer. Although the mechanisms by which HSPs protect cells are not clearly understood, their expression can be modulated by cell signal transducers, such as changes in intracellular pH, cyclic AMP, Ca2+, Na+, inositol trisphosphate, protein kinase C, and protein phosphatases. Most of the HSPs interact with other proteins in cells and alter their function. These and other protein-protein interactions may mediate the little understood effects of HSPs on various cell functions. In this review, we focus on the structure of the HSP-70 family (HSP-70s), regulation of HSP-70 gene expression, their cytoprotective effects, and the possibility of regulating HSP-70 expression through modulation of signal transduction pathways. The clinical importance and therapeutic potential of HSPs are discussed.

PubMed Disclaimer

Publication types

• Review Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search

MeSH terms

• Animals Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Autoimmune Diseases / drug therapy Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Calcium / physiology Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Communicable Diseases / drug therapy Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Cyclic AMP / physiology* Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Forecasting Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• HSP70 Heat-Shock Proteins* / chemistry Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• HSP70 Heat-Shock Proteins* / physiology Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• HSP70 Heat-Shock Proteins* / therapeutic use Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Heat Stress Disorders / prevention & control* Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Humans Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Hydrogen-Ion Concentration Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Immune System Diseases / drug therapy Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Inositol 1,4,5-Trisphosphate / physiology Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Neoplasms / drug therapy Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search

Substances

• HSP70 Heat-Shock Proteins Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Inositol 1,4,5-Trisphosphate Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Cyclic AMP Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Calcium Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information

• Miscellaneous

  • NCI CPTAC Assay Portal

Full text links [x] Elsevier Science [x] Cite Copy Download .nbib .nbib Format: AMA APA MLA NLM Send To

• Clipboard
• Email
• Save
• My Bibliography
• Collections
• Citation Manager

[x]

NCBI Literature Resources

MeSH PMC Bookshelf Disclaimer

The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.