HIST1H1E - Histone Cluster 1, H1e - WikiGenes

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound    Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008) [search][options]Editor

• Edit this page
• Discussion
• History
• Edit alert 
• Permanent link
• Print
• Export

Share

• Send to a friend
• Share

Personal info

• Your homepage
• Your articles
• Create article

 View

• Font size
• Color scheme

Links

HIST1H1E	Bos taurus
LOC696872	Macaca mulatta
LOC471881	Pan troglodytes

Homology information is based on Homologene.
• Homologues
• NCBI Gene
• NCBI SNP
• iHOP resource
• OMIM
• SNPedia
• UniProt
• Ensembl
• HGNC

Table of contents

• Disease relevance of HIST1H1E

• High impact information on HIST1H1E

• Biological context of HIST1H1E

• Anatomical context of HIST1H1E

• Associations of HIST1H1E with chemical compounds

• Other interactions of HIST1H1E

About

• Introduction
• Tutorial
• About
• Contact us
• Language [English]

Terms

• Terms of Use
• Privacy Policy
• Open Access

 

 [edit this page]Gene Review: HIST1H1E  -  histone cluster 1, H1eHomo sapiensSynonyms: H1.4, H1E, H1F4, H1e, H1s-4, ...    Sarg, B. et al., Meergans, T. et al., Davie, J.R. et al., Kratzmeier, M. et al., Yasutomo, Y. et al., et al.    Pałyga,  Górnicka-Michalska,  Kowalski,  Ksiazkiewicz,   Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more. Welcome to WikiGenes! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text.

Ideally this entry shall become one comprehensive and continuous article. Bulleted lists, for instance, were only used because it is impossible to automatically integrate independent facts into a continuous text.

Much of the current information on this page has been automatically compiled from Pubmed.

This precompiled information serves as a substrate and matrix to embed your contributions, but it is by no means the final word - Homo sapiens can do much better!

WikiGenes is a non-profit and open access community project - Read more.

 

Disease relevance of HIST1H1E

• These results indicate that the AC inhibitor in the pancreatic cancer extract is histone H1b or H1d and histones H2A, H2B and H3 also have an AC inhibitory activity [1].
• The AAA-->AGA codon change in H1.4 was detected only in Raji cells and was not present in a normal population or in six other cell lines derived from individuals suffering from Burkitt's lymphoma [2].
• Monoubiquitinated histone H1B is required for antiviral protection in CD4(+)T cells resistant to HIV-1 [3].

 

High impact information on HIST1H1E

• During early apoptosis of three of these cell lines, we observed the induction of internucleosomal DNA cleavage and, simultaneously, a typical change in the histone H1 protein pattern, leading to an increase in the relative amounts of histone subtypes H1.4 and H1 [4].
• Histone H1b was isolated, and the N-terminal amino acid sequence of histone H1b was found to be highly similar to that of mammalian histone H1(0) and duck H5 [5].
• Histone H1b was present in the chromatin of liver, but not in the chromatin of hepatocellular carcinoma, testis or erythrocyte [5].
• Natural allelic variation of duck erythrocyte histone H1b [6].
• The H1.4 gene is associated with an H2B gene, whereas genes coding for all four core histones are located in the vicinity of the H1.3 gene [7].

 

Biological context of HIST1H1E

• One of these phosphorylation sites was found on the serine residue on the H1.4 peptide KARKSAGAAKR [8].

 

Anatomical context of HIST1H1E

• With the exception of H1.2 and H1.4, we found substantial differences between the H1 mRNA levels in the different cell lines tested [9].

 

Associations of HIST1H1E with chemical compounds

• In K562 erythroleukemic cells, alanine at position 17 in H1.2 was replaced by valine, and, in Raji B lymphoblastoid cells, lysine at position 173 in H1.4 was replaced by arginine [2].

 

Other interactions of HIST1H1E

• In contrast to the differential patterns of the other subtypes, H1.2 and H1.4 were in all cells expressed at a high level, indicating a basal function compared with the other H1 histones [9].

References

1. Purification and partial sequencing of inhibitory factor on renal membrane adenylate cyclase in pancreatic cancer extract: identity with histones H1b or H1d. Yasutomo, Y., Suga, T., Wada, S., Kosano, H., Takishima, K., Mamiya, G., Kugai, N., Nagata, N. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
2. Characterization of sequence variations in human histone H1.2 and H1.4 subtypes. Sarg, B., Gréen, A., Söderkvist, P., Helliger, W., Rundquist, I., Lindner, H.H. FEBS J. (2005) [Pubmed]
3. Monoubiquitinated histone H1B is required for antiviral protection in CD4(+)T cells resistant to HIV-1. Lesner, A., Kartvelishvili, A., Lesniak, J., Nikolov, D., Kartvelishvili, M., Trillo-Pazos, G., Zablotna, E., Simm, M. Biochemistry (2004) [Pubmed]
4. Changes in the protein pattern of H1 histones associated with apoptotic DNA fragmentation. Kratzmeier, M., Albig, W., Meergans, T., Doenecke, D. Biochem. J. (1999) [Pubmed]
5. Characterization and chromatin distribution of the H1 histones and high-mobility-group non-histone chromosomal proteins of trout liver and hepatocellular carcinoma. Davie, J.R., Delcuve, G.P. Biochem. J. (1991) [Pubmed]
6. Natural allelic variation of duck erythrocyte histone H1b. Pałyga, J., Górnicka-Michalska, E., Kowalski, A., Ksiazkiewicz, J. Int. J. Biochem. Cell Biol. (2000) [Pubmed]
7. Isolation and characterization of two human H1 histone genes within clusters of core histone genes. Albig, W., Kardalinou, E., Drabent, B., Zimmer, A., Doenecke, D. Genomics (1991) [Pubmed]
8. Characterization of phosphorylation sites on histone H1 isoforms by tandem mass spectrometry. Garcia, B.A., Busby, S.A., Barber, C.M., Shabanowitz, J., Allis, C.D., Hunt, D.F. J. Proteome Res. (2004) [Pubmed]
9. Varied expression patterns of human H1 histone genes in different cell lines. Meergans, T., Albig, W., Doenecke, D. DNA Cell Biol. (1997) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg