Specific Inhibitory Effect Of H1e Histone Somatic Variant On In Vitro ...

Clipboard, Search History, and several other advanced features are temporarily unavailable. Skip to main page content

The .gov means it’s official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation Search: Search Advanced Clipboard Save Email Send to

• Clipboard
• My Bibliography
• Collections
• Citation manager

Display options Display options Format Abstract PubMed PMID

Save citation to file

Format: Summary (text) PubMed PMID Abstract (text) CSV Create file Cancel

Email citation

Email address has not been verified. Go to My NCBI account settings to confirm your email and then refresh this page. To: Subject: Body: Format: Summary Summary (text) Abstract Abstract (text) MeSH and other data Send email Cancel

Add to Collections

• Create a new collection
• Add to an existing collection

Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error Please try again Add Cancel

Add to My Bibliography

• My Bibliography

Unable to load your delegates due to an error Please try again Add Cancel

Your saved search

Name of saved search: Search terms: Test search terms Would you like email updates of new search results? Saved Search Alert Radio Buttons

• Yes
• No

Email: (change) Frequency: Monthly Weekly Daily Which day? The first Sunday The first Monday The first Tuesday The first Wednesday The first Thursday The first Friday The first Saturday The first day The first weekday Which day? Sunday Monday Tuesday Wednesday Thursday Friday Saturday Report format: Summary Summary (text) Abstract Abstract (text) PubMed Send at most: 1 item 5 items 10 items 20 items 50 items 100 items 200 items Send even when there aren't any new results Optional text in email: Save Cancel

Create a file for external citation management software

Create file Cancel

Your RSS Feed

Name of RSS Feed: Number of items displayed: 5 10 15 20 50 100 Create RSS Cancel RSS Link Copy

Full text links

Elsevier Science Full text links

Actions

CiteCollectionsAdd to Collections

• Create a new collection
• Add to an existing collection

Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an errorPlease try again Add Cancel PermalinkPermalinkCopyDisplay options Display options Format AbstractPubMedPMID

Page navigation

• Title & authors
• Abstract
• Publication types
• MeSH terms
• Substances
• LinkOut - more resources

Title & authors Abstract Publication types MeSH terms Substances LinkOut - more resources Full text links CiteDisplay options Display options Format AbstractPubMedPMID

Abstract

H1e and H1c histone variants were purified from mouse L929 fibroblasts using a reverse phase HPLC, and their effect on in vitro DNA methylation was investigated, together with their ability to bind unmethylated or methylated CpG-rich 44bp oligonucleotides. In a "physiological" range of H1:DNA ratios only H1e, at variance from H1c, was found to cause a marked inhibition of in vitro enzymic DNA methylation. It was also shown that both variants have a similar affinity in binding a methylated CpG-rich oligonucleotide, but that the binding to the same oligonucleotide in the unmethylated form occurs preferentially with H1e rather than with H1c. H1e is therefore likely to be directly involved in maintaining CpG-rich sequences in the unmethylated state.

PubMed Disclaimer

Publication types

• Research Support, Non-U.S. Gov't Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search

MeSH terms

• Animals Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Base Sequence Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Cell Line Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• CpG Islands Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• DNA / genetics Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• DNA / metabolism* Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Genetic Variation Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Histones / genetics* Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Histones / metabolism* Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Histones / pharmacology Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Methylation Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Mice Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Molecular Sequence Data Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Oligodeoxyribonucleotides / genetics Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Oligodeoxyribonucleotides / metabolism Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Protein Binding Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search

Substances

• Histones Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Oligodeoxyribonucleotides Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• DNA Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

Full text links [x] Elsevier Science [x] Cite Copy Download .nbib .nbib Format: AMA APA MLA NLM Send To

• Clipboard
• Email
• Save
• My Bibliography
• Collections
• Citation Manager

[x]

NCBI Literature Resources

MeSH PMC Bookshelf Disclaimer

The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.