Hrisi Bahar-Tokman

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Papers by Hrisi Bahar-Tokman

The Distribution of Aerobic and Anaerobic Bacteria in the Etiology of Granulomatous Mastitis and Their Resistance to Antimicrobial AgentsKlimik Dergisi/Klimik Journal, 2021The Distribution of Aerobic and Anaerobic Bacteria in the Etiology of Granulomatous Mastitis and ... more The Distribution of Aerobic and Anaerobic Bacteria in the Etiology of Granulomatous Mastitis and Their Resistance to Antimicrobial Agents ÖZET Amaç: Granülomatöz mastit (GM), memenin nadir görülen kronik inflamatuar bir hastalığıdır. Non-laktasyonel mastitin en sık rastlanılan türü olan GM' de, etyolojik rolü olan bakteriler tam olarak bilinmemektedir.Download The association between cagL and cagA, vacAs-m, babA genes in patients with gastric cancer, duodenal ulcer, and non-ulcer dyspepsia related to Helicobacter pyloriActa gastro-enterologica Belgica, 2020INTRODUCTION As a component of the cag T4SS, the cagL gene is involved in the translocation of Ca... more INTRODUCTION As a component of the cag T4SS, the cagL gene is involved in the translocation of CagA into host cells and is essential for the formation of cag PAI-associated pili between H. pylori and gastric epithelial cells. AIM We aimed to investigate the clinical association of the cagL gene with other virulence factors (VacA, CagA, EPIYA-C, and BabA protein) of H. pylori strains isolated from GC, duodenal ulcer (DU), and non-ulcer dyspepsia (NUD) cases. METHODS The patient group (PG), including 47 patients (22 GC and 25 DU) and a 25 control group (CG= NUD) were included. Amplification of the H. pylori cagL, cagA, vacA, and babA2 genes and typing of EPIYA motifs were performed by PCR methods. RESULTS Sixty-one (84.7%) H. pylori strains were detected with cagL (93.6% in SG, 68% in CG). We detected a significant difference between SG and CG for the presence of cagL (p=0.012) but no statistical comparison was done for (≥2) EPIYA-C repeats In the comparison of H. pylori strains with ...format_quotePresence of cagL genotype significantly differs between groups (p=0.012); vacAs1m1 and EPIYA-C repeats increase GC/DU risk substantially (OR: 2.829 and 3.524, respectively).format_quoteDownload FEMS-2210, Propionibacterium Acnes in Biomaterials-Associated Infection :Frequency and Antimicrobial ResistanceTurkey Background Propionibacterium acnes can cause invasive deep seated infections, usually in t... more Turkey Background Propionibacterium acnes can cause invasive deep seated infections, usually in the setting of implantable devices and its antimicrobial resistance is beginning to emerge. Objectives P.acnes can act as an opportunistic pathogen causing invasive and chronic biomaterials-associated infection through a biofilm mode of growth. In this study we aimed to review the frequency and the antimicrobial resistance of P. acnes in infections involving implants. Methods From March 2011 to April 2014, cerebrospinal fluid specimens (CFS) of 46 patients with internal shunt infection (ISI), corneal scrapings (CS) of 55 patients with delayed postoperative endophthalmitis (DPE) developped after lens implantation, periprosthetic tissues (PT) of 11 patients with prosthetic shoulder infection (PSI) and 17 patients with prosthetic joints infection (PJI)were studied. Samples were inoculated on supplemented Schaedler agars and fluid thioglycolate medium and were incubated during 15 days in anae... Bacteriological evaluation of tonsillar microbial flora according to age and tonsillar size in recurrent tonsillitisEuropean Archives of Oto-Rhino-Laryngology, 2014Although numerous studies based on the bacteriology of the tonsil have been carried out, none of ... more Although numerous studies based on the bacteriology of the tonsil have been carried out, none of them analyzed the variation of tonsillar flora with respect to both age and tonsillar size. The purpose of this study was to isolate the facultative and obligate anaerobes both from the surface and the core of tonsils in recurrent tonsillitis as well as to analyze the variation of isolated bacterial strains according to age and tonsillar size. A prospective study was performed on 111 patients who underwent tonsillectomy. We analyzed the differences between the bacterial pathogens in recurrent tonsillitis and semi-growth estimates with regard to age and tonsillar grade. Among 111 cases, 604 bacterial strains of 21 different from the tonsil superficial and core were isolated. The most common facultative anaerobic species isolated from the surface and core were Coagulase-negative staphylococci, Alpha-hemolytic streptococci and Diphtheroid bacilli in all subgroups except patients below 8 years old. The most commonly obligate anaerobic species isolated from the core were Propionibacterium acnes, Prevotella melaninogenica and Peptostreptococcus anaerobius. We found no significant difference in the cultured bacteria with respect to age and tonsillar size. The study subgroups did not differ in the occurrence of semiquantitative growth estimates of 3-4+. Our study demonstrates that there is polymicrobial aerobic and anaerobic flora in tonsils with regardless of patient&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s age and tonsillar size. This polymicrobial spectrum of bacteria may contribute to recurrence and to the failure of conservative treatment of these cases and therefore leads to surgical therapy. Similar bacterial signatures in the gut microbiota of type 1 and type 2 diabetes patients and its association with G protein-coupled receptor 41 and 43 gene expressionJournal of Diabetes &amp; Metabolic Disorders Randomized double-blind trial of wipes containing terpinen-4-ol and hyaluronate versus baby shampoo in seborrheic blepharitis patientsEye, 2021To investigate the efficacy of lid wipes (LWs) containing terpinen-4-ol and sodium hyaluronate (H... more To investigate the efficacy of lid wipes (LWs) containing terpinen-4-ol and sodium hyaluronate (Hy-ter®) for the treatment of seborrheic blepharitis compared to baby shampoo (BS). This randomized, double-blind, active control, parallel group, multicentre clinical trial included 48 eyes of 48 patients with seborrheic blepharitis who were randomly divided into two treatment arms (1:1, n = 24) using block randomization. LWs or BS were prescribed twice a day for 8 weeks followed by a discontinuation period of 4 weeks. Change in Blepharitis Symptom measure (BLISS), Schirmer’s test, tear breakup time (TBUT), noninvasive TBUT (NI-TBUT), ocular surface disease index (OSDI) score, corneal and conjunctival staining, meibography, and Demodex count at different visits (Baseline, 4th, 8th, and 12th week) were the main outcome measures. The baseline values of both groups were similar (p &gt; 0.05). Despite high clinical efficacy in both treatment arms, patients using LWs showed a lower BLISS score at the 8th and 12th-week visit (1.9 ± 2.2 versus 7.2 ± 6.6, p = 0.003; 4.0 ± 1.3 versus 5.8 ± 6.3, p = 0.026). NI-TBUT showed a significant increase starting from the 4th week for patients using LWs and 8th week for patients using BS. Both treatment modalities caused a reduction in the Demodex count after 4 weeks of treatment (p &lt; 0.001). The treatment withdrawal did not cause any recurrence in both treatment arms. BS or LWs containing Hy-ter® can be used with good efficacy for the treatment of seborrheic blepharitis. However, LWs may provide a better symptomatic relief compared to BS after 8 weeks of treatment. Point Mutations at gyrA and gyrB Genes of Levofloxacin Resistant Helicobacter pylori Strains and Dual Resistance with ClarithromycinClinical Laboratory, 2021BACKGROUND Spontaneous point mutations in genes encoding gyrA/B subunits of DNA gyrase are respon... more BACKGROUND Spontaneous point mutations in genes encoding gyrA/B subunits of DNA gyrase are responsible for fluoroquinolone resistance. We aimed to determine the clarithromycin and levofloxacin resistance phenotypically in H. pylori strains and to investigate the mutations responsible for levofloxacin resistance and the effects of these mutations on dual antibiotic resistance. METHODS A total of 65 H. pylori isolates were included. The E-test method was used for the clarithromycin and le-vofloxacin antimicrobial susceptibility test. Real-time PCR was used to detect the point mutations. RESULTS Twenty-four (36.9%) of 65 H. pylori strains were phenotypically resistant to clarithromycin and 14 (21.5%) to levofloxacin. The phenotypic levofloxacin resistance rate of strains with Asn87Lys and Asp91Asn mutations were significantly higher (gyrA gene) (p &lt; 0.05). The phenotypic levofloxacin resistance rate of strains with Arg484Lys and Asp481Glu mutations were significantly higher (gyrB gene) (p &lt; 0.05). The Asn87Lys mutation increased the risk of phenotypes being resistant to levofloxacin 70.156 times and Asp91Asn mutation increased 125,427 times higher. Seven (10.8%) of 65 H. pylori strains showed dual resistance to both levofloxacin and clarithromycin. The rate of being dual resistant with A2143G mutation (clarithromycin resistance) was found to be significantly higher (p &lt; 0.05). CONCLUSIONS The Asn87Lys and Asp91Asn mutations in the gyrA gene had a phenotypically enhancing effect on levofloxacin resistance, while the presence of Asp481Glu and Arg484Lys mutations in the gyrB gene did not. The existence of dual resistance was developed with the increase in clarithromycin and levofloxacin resistance rates. Investigation of the Demodex Lid Infestation with in Vivo Confocal Microscopy versus Light Microscopy in Patients with Seborrheic BlepharitisOcular Immunology and Inflammation, 2021Aim: The comparison of the diagnostic efficiency of a reference method (light microscopy [LM] usi... more Aim: The comparison of the diagnostic efficiency of a reference method (light microscopy [LM] using 10% potassium hydroxide [KOH]) with the use of 100% alcohol to in vivo confocal microscopy (IVCM) for the detection of Demodex eyelid infestation in seborrheic blepharitis patients. Methods: Eyelashes were epilated from the right eyes for the reference method and the left eyes for the alcohol group in 58 eyes of 29 patients. IVCM was used on the left eyes. The primary outcomes were the number of Demodex mites per lash and the rate of Demodex positivity (≥1 mite). Results: The rate of Demodex positivity was similar among the three groups (KOH: 82.8%, alcohol: 86.2%, IVCM: 72.4%; p &gt;.05). The mean number of mites per lash in the KOH group (1.5 ± 1.3) was higher than in the alcohol (0.9 ± 0.6, p =.041) and IVCM groups (0.9 ± 0.9, p =.036). Conclusion: KOH was found to be superior in terms of the quantification of mites compared to alcohol and IVCM. The Relationship Between the Use of Hydrogel and Silicone Hydrogel Contact Lenses and Coagulase-Negative Staphylococci Population in the Conjunctiva and Biofilm Forming Staphylococcus epidermidisTürk Mikrobiyoloji Cemiyeti Dergisi, 2021Objective: The most important bacteria of the conjunctival microbiota are Staphylococcus epidermi... more Objective: The most important bacteria of the conjunctival microbiota are Staphylococcus epidermidis, diphteroid rods, Corynebacterium spp. and Cutibacterium acnes. Especially biofilm formation of S. epidermidis is very important for contact lens related infections. For this purpose, we aimed to examine the changes in the presence of biofilm-forming S. epidermidis and other coagulase-negative staphylococci in conjunctival swabs taken before and after lens usage in 140 patients (90 hydrogel, 50 silicone hydrogel) who were prepared to wear lenses. Methods: Coagulase-negative staphylococci isolated from the conjunctival microbiota identified standard clinical microbiological methods, after identification of S.epidermidis strains with API Staph; Slime production was determined by Congo red agar, standard tube and molecular methods. Results: S.epidermidis was the most frequently isolated species in conjunctival microbiota before and after lens usage. Before lens usage, slime positive S. ...Download Swabs Containing Tea Tree Oil and Chamomile Oil Versus Baby Shampoo in Patients With Seborrheic Blepharitis: A Double-Blind Randomized Clinical TrialEye &amp; Contact Lens: Science &amp; Clinical Practice, 2021PURPOSE The comparison of the efficacy of swabs containing tea tree oil and chamomile oil and bab... more PURPOSE The comparison of the efficacy of swabs containing tea tree oil and chamomile oil and baby shampoo (BS) in the treatment of seborrheic blepharitis was aimed. METHODS This randomized, double-blind, parallel-group, active control, multicenter clinical trial included patients with seborrheic blepharitis using block randomization (BS, n=23; swabs, n=26). Patients were treated with BS or swabs for 8 weeks followed by 4 weeks of treatment withdrawal. Change in Blepharitis Symptom measure (BLISS), Demodex count, Ocular Surface Disease Index (OSDI) score, Schirmer test, tear breakup time (TBUT), noninvasive TBUT (NI-TBUT), corneal staining, and meibography at different visits (baseline, fourth, , and 12th week) were the main outcome measures. RESULTS Patients in both groups showed similar baseline parameters (P&gt;0.05). Patients using swabs showed significantly lower BLISS scores compared with patients using BS at the 4th, 8th, and 12th week visits (3.6±6.1 vs. 6.3±4.5 P=0.011; 1.1±2.8 vs. 6.6±6.7, P&lt;0.001; 0.9±2.8 vs. 5.7±6.6, P=0.002, respectively). Patients using swabs showed improvement in OSDI scores after 8 weeks of treatment compared with the baseline visit (P&lt;0.001). Despite a similar Demodex reduction effect in both treatment arms even after 4 weeks of treatment (P&lt;0.001), both treatment modalities did not show any effect on the other parameters. CONCLUSION Although both swabs and BS showed efficacy for the treatment of seborrheic blepharitis in terms of the Demodex reduction and symptomatic improvement, swabs may provide better symptomatic improvement. Four weeks of treatment discontinuation may not cause any recurrence in the symptoms or Demodex infestation. Effect of scleral lens use on conjunctival microbiotaContact Lens and Anterior Eye, 2019This study aimed to investigate the effect of scleral lens (SL) use on conjunctival microbiota. M... more This study aimed to investigate the effect of scleral lens (SL) use on conjunctival microbiota. Method: A total of 26 eyes of 26 patients using an SL and 25 eyes of 25 healthy controls were included in the study. The samples were obtained from the lower fornices of the eyes using sterile swabs. For the bacteriological examination, a bacterial culture was obtained by inoculating the samples on chocolate agar, blood agar, MacConkey agar, and fluid thioglycollate medium. After 24-48 h of incubation at 37 0 C, the growth of different colonies of bacteria was identified using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (Bruker MALDI Biotyper). Results: The mean age of the study group was 41.6 ± 19.1 years (18-65); the mean age of the control group was 40 ± 6 (21-62) (p = 0.69). There were 10 male patients and 16 female patients in the study group and 9 male patients and 16 female patients in the control group (p = 0.86). The mean duration of SL use was 13.7 ± 13.4 months (1-42 months). No bacterial growth was observed in 17 (65.4 %) of the 26 eyes in the SL group and 5 (20 %) of the 25 eyes in the control group (p = 0.001). The most commonly observed microorganisms were Staphylococcus epidermidis (S.epidermidis) and Staphylococcus aureus (S.aureus) in both groups. Conclusion: SL users were found to have a higher rate of culture negativity in comparison to the healthy controls, suggesting that SLs have a significant effect on conjunctival microbiota.Download Bacteroidetes and Firmicutes levels in gut microbiota and effects of hosts TLR2/TLR4 gene expression levels in adult type 1 diabetes patients in Istanbul, TurkeyJournal of Diabetes and its Complications, 2019This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.format_quoteT1DM patients showed elevated Bacteroidetes, reduced Firmicutes, and altered TLR2/TLR4 expression, suggesting a link between gut microbiota and T1DM.format_quoteDownload Travel-associated infections caused by unusual serogroups of Legionella pneumophila identified using Legionella BIOCHIP slides in Turkey and IraqTravel Medicine and Infectious Disease, 2016Background: Although Legionella pneumophila serogroup 1 is the common disease causing serogroup, ... more Background: Although Legionella pneumophila serogroup 1 is the common disease causing serogroup, rare serogroups can also may cause legionellosis. A 54-year-old male patient (index case) reported that he had been on a religious trip (for visiting, tomb of Ali, which is important for Shias) to Iraq with a large group (50 shia pilgrims from Kars city of Turkey) two weeks prior to admission. Due to civil war, the hotel where the patient stayed in Iraq lacked proper hygiene. A large number of people in the travel group were experiencing the sameDownload Aerobic bacteria in infected breast of Turkish woman: Prevalence and antimicrobial resistance evaluated in cases with lactational mastitis, periductal mastititis and granulomatous mastitisInternational Journal of Infectious Diseases, 2016Background: Mastitis is a disease causing serious psychological and physical difficulties in wome... more Background: Mastitis is a disease causing serious psychological and physical difficulties in women. We report the aerobic bacteria isolated from infected breasts of 44 women diagnosed with lactational mastitis (LM), 10 with periductal mastitis (PM) and 46 diagnosed with granulomatous mastitis (GM). Methods & Materials: Between November2015-June 2015, pus specimens of 100 women diagnosed with mastitis were Gram stained and aerobic cultures were performed. The isolated bacteria were identified by standart microbiological methods and by Phoenix microbiology analyzer (BD Phoenix TM). From 1 LM patient and 19 GM patient's pus samples which showed bacteria on their Gram-stained smears but had sterile cultures, bacterial DNA was isolated. After extraction, the DNA was purified and PCR amplification procedures were performed. 1446-1515nt amplicons were sequenced using the BigDye Terminator v3.1 kit (Applied Biosystems, USA). DNA sequences were examined and edited using MEGA software. Antimicrobial sensitivities of bacteria isolated from cultures were determined by the disc diffusion method. The results were evaluated according to EUCAST 2015 documents. Results: Aerobic bacteria were isolated from 31(70,4%) LM, 6(60%) PM and 19(41,3%) GM patient's samples, S.aureus was found as the most prevalent bacteria (43,1%, 60% respectively) in LM and PM patients. However C.kroppenstedtii was found as the most prevalent bacteria (15,2%) in GM patient's samples. Furthermore, 2 S.aureus, 3 S.epidermidis, 1 S.capitis, 1 Streptococcus spp. 1 S.mitis, 1 L.lactis, 1 K.pneumoniae, 3 C.kroppenstedtii, 1 C.pseudotuberculosis, 1 C.urealyticum DNA were determined from 19(28%) GM patient samples. A statistically significant relation was found between Gram positive bacteria and GM (p<0.05). The most effective antibiotics were trimethoprim-sulfamethoxazole, gentamicin, ciprofloxacin, vancomycin, linezolid for Gram(+)diplococci, ceftazidime, amoxicillin/clavulanic acid, imipenem and gentamicin for Gram(-)bacilli and penicillin, gentamicin, vancomycin, linezolid for Gram(+)bacilli. Conclusion: As a result, for the first time, the bacteria that until now appeared only in animal mastitis (S.saprophyticus, S.capitis, L.lactis) were determined on human granulomateous mastitis. We believe that, the addition of antibiotics penetrating strongly to the adipose tissue and effective on the most common isolated bacteria would be beneficial for the treatment of patients with mastitis.Download A Retrospective Analysis of Anaerobic Bacteria Isolated in 236 Cases of Pleural Empyema and their Prevalance of Antimicrobial Resistance in TurkeyClinical laboratory, 2018Parapneumonic effusions usually occur secondary to an infection and produce pus (empyema) that ac... more Parapneumonic effusions usually occur secondary to an infection and produce pus (empyema) that accumulates in the pleural space. We aimed to evaluate the prevalence of anerobes in patients with empyema and to assess their resistance patterns for seven antimicrobials. Pleural fluid specimens from 236 patients were inoculated on Schaedler agar. Anaerobic bacteria were identified via API 20 A. Susceptibility testing for penicillin, ampicillin + sulbactam, amoxicillin + clavulanate, cefoxitin, clindamycin, metronidazole, and imipenem were performed with the E-test. There were 118 anaerobic bacterial strains detected in 66 (27.9%) of the 236 specimens. Gram-positive anaerobic cocci were detected in 54.23% and the predominant cocci were 41 Peptostreptococcus spp, (34.75%) followed by 17 P. acnes (14.41%) and 6 C. tertium (5.08%). The Gram-negative anaerobes were B. fragilis (28, 23.73%), P. melaninogenica (8, 6.78%), P. intermedia (4, 3.39%), F. nucleatum (6, 5.08%), F. mortiferum (5, 4.2... Evaluation of Syphilis Coinfection in HIV-Infected IndividualsKlimik Dergisi\/klimik Journal, 2020 H. pylori-miRNA interaction in gastric cancer tissues: First prospective study from TurkeyThe new microbiologica, 2019Helicobacter pylori (H. pylori) is involved in the etiology of gastric cancer (GC). miRNAs are sh... more Helicobacter pylori (H. pylori) is involved in the etiology of gastric cancer (GC). miRNAs are short RNAs that regulate gene expression by marking mRNAs for degradation. miRNAs are involved in tumorigenesis, metastasis, and cell proliferation. We aimed to investigate the miRNA expression profiles of tissues from H. pylori (+) and (-) GC patients. Forty GC patients, 20 H. pylori (+) and 20 H. pylori (-), and a healthy control group were included. The miRNA expression levels were investigated by microarrays and quantitative RT-PCR. We detected 9 upregulated and 4 downregulated miRNAs by microarray. We selected 5 upregulated and 5 downregulated miRNAs for the quantitative RT-PCR assay. The relative fold changes of miRNAs in the cancerous tissue and non-tumor mucosa specimens of H. pylori (+) GC patients for hsa-miR-194 were 4.24- and 3.83-fold higher, respectively, whereas the hsa-miR-145 expression levels were downregulated 0.33-fold and 0.43-fold, respectively, in the same group. The...Download Antimicrobial resistance of Helicobacter pylori strains to five antibiotics, including levofloxacin, in Northwestern TurkeyINTRODUCTION Antibiotic resistance is the main factor that affects the efficacy of current therap... more INTRODUCTION Antibiotic resistance is the main factor that affects the efficacy of current therapeutic regimens against Helicobacter pylori. This study aimed to determine the rates of resistance to efficacy clarithromycin, amoxicillin, tetracycline, levofloxacin and metronidazole among H. pylori strains isolated from Turkish patients with dyspepsia. METHODS H. pylori was cultured from corpus and antrum biopsies that were collected from patients with dyspeptic symptoms, and the antimicrobial susceptibility of H. pylori was determined using the E-test (clarithromycin, amoxicillin, tetracycline, metronidazole and levofloxacin) according to the EUCAST breakpoints. Point mutations in the 23S rRNA gene of clarithromycin-resistant strains were investigated using real-time PCR. RESULTS A total of 98 H. pylori strains were isolated, all of which were susceptible to amoxicillin and tetracycline. Of these strains, 36.7% (36/98) were resistant to clarithromycin, 35.5% (34/98) were resistant to ...format_quoteResistance rates for clarithromycin (36.7%), metronidazole (35.5%), and levofl oxacin (29.5%) are alarmingly high in Turkish H. pylori strains.format_quoteDownload CTX-M-15 type extended spectrum β-lactamase producing Escherichia coli and Klebsiella pneumoniae: A developing problem in infected outpatients and hospitalised patients in Istanbul, TurkeyExtented-spectrum β-lactamase (ESBL) producing Escherichia coli and Klebsiella pneumoniae were sh... more Extented-spectrum β-lactamase (ESBL) producing Escherichia coli and Klebsiella pneumoniae were shown to be a significant cause of both community-acquired and hospital-acquired infections worldwide. The aim of this study was to compare the epidemiological feature of CTX-M, TEM and SHV producing pathogenic E. coli and K. pneumoniae strains in outpatients and hospitalised patients. Antimicrobial susceptibilities of 551 E. coli and 62 K. pneumoniae strains isolated as pathogenic bacteria were determined by disc diffusion method and ESBLs were characterised by isoelectric focusing and PCR. ESBL production was found in 17.4% of the E. coli and 33.9% of the K. pneumoniae strains. CTX-M type ESBL production was determined in 94.8% of the E. coli and 81% of the K. pneumoniae strains and their sequence analysis revealed the presence of CTX-M-15. Our ESBL producing strains had an excellent susceptibility to imipenem, meropenem and ertapenem. According to the usage of molecular methods, the epi...Download The role of Helicobacter cinaedi in the development of atherosclerosisPostępy Higieny i Medycyny DoświadczalnejHelicobacter cinaedi (H. cinaedi) is a Gram-negative curved motile rod that causes bloodstream or... more Helicobacter cinaedi (H. cinaedi) is a Gram-negative curved motile rod that causes bloodstream or enteric infections. It was suggested that H. cinaedi was involved in the progression of atherosclerosis. We aimed to investigate the presence of H. cinaedi DNA using a nested-polymerase chain reaction (PCR) in atheroma plaques from patients with atherosclerosis-induced vascular diseases. A total of 129 patients diagnosed with valvular heart disease due to atherosclerosis and 146 patients with non-atherosclerotic post-stenotic dilatation were included as the patient and the control groups, respectively. The ATCC BA847 H. cinaedi strain was used as the positive control for the nested-PCR method. We investigated H. cinaedi DNA in our study groups using the nested-PCR method and detected only six H. cinaedi DNA (4.65%) in the 129 atherosclerotic patient group. We detected significant difference between patient and control groups with respect to the presence of H. cinaedi on the basis of Fis...format_quoteNo causal relationship found between H. cinaedi and atherosclerosis despite associations with age and cholesterol as risk factors.format_quoteDownload ×Close

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