Learn: Cell Lines - The Human Protein Atlas

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Search Fields » Search result AND NOT Field AllGene nameProtein classUniprot keywordChromosomeExternal idTissue expression (IHC)Multiplex tissue (IHC)Patient ID (IHC)Secretome annotationTissue category (RNA)Tissue Tau score (RNA)Tissue expression cluster (RNA)Reliability score tissue (IHC)Brain region category (RNA)Brain Tau score (RNA)Mouse brain category (RNA)Mouse brain Tau score (RNA)Pig brain category (RNA)Pig brain Tau score (RNA)Brain expression cluster (RNA)Reliability score mouse brainCell type enrichment (RNA)Cell type category (scRNA)Cell type Tau score (RNA)Cell type group category (scRNA)Cell type group Tau score (RNA)Brain region cell type (scRNA)Brain region Tau score (scRNA)Immune cell category (RNA)Immune cell Tau score (RNA)Immune cell lineage category (RNA)Immune cell lineage Tau score (RNA)Immune cell expression cluster (RNA)Single cell type expression cluster (RNA)Subcellular location (ICC)Subcellular location - cell line (ICC)Predicted locationSubcellular Cell Cycle Peak PhaseReliability score cells (ICC)Prognostic cancerCancer category (RNA)Cell line category (RNA)Celline Tau score (RNA)Cell line expression cluster (RNA)Protein sequence variantsProtein interactionProtein interaction countMetabolic pathwayStructure ipTMEvidence summaryUniProt evidenceNeXtProt evidenceHPA evidenceProtein array (PA)Western blot (WB)Immunohistochemistry (IHC)Immunocytochemistry (ICC)With antibodiesHas dataSort by Term Gene name Class Blood group antigen proteinsCancer-related genesCandidate cardiovascular disease genesCD markersCitric acid cycle related proteinsDisease related genesEnzymesEssential proteinsFDA approved drug targetsG-protein coupled receptorsHuman disease related genesImmunoglobulin genesMapped to neXtProtMapped to UniProt SWISS-PROTMetabolic proteinsNuclear receptorsPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteinsProtein evidence (Ezkurdia et al 2014)Protein evidence (Kim et al 2014)RAS pathway related proteinsRibosomal proteinsRNA polymerase related proteinsT-cell receptor genesTranscription factorsTransportersVoltage-gated ion channels Subclass Category Biological processMolecular functionDisease Keyword Chromosome 12345678910111213141516171819202122MTUnmappedXY External id Tissue AnyAdipose tissueAdrenal glandAppendixBone marrowBreastBronchusBrown adipose tissueCartilageCaudateCerebellumCerebral cortexCervixChoroid plexusColonDorsal rapheDuodenumEfferent ductsEndometriumEpididymisEsophagusEyeFallopian tubeGallbladderHairHeart muscleHippocampusHypothalamusKidneyLactating breastLiverLungLymph nodeNasopharynxOral mucosaOvaryPancreasParathyroid glandPituitary glandPlacentaProstateRectumRetinaSalivary glandSeminal vesicleSkeletal muscleSkinSmall intestineSmooth muscleSoft tissueSole of footSpleenStomachSubstantia nigraTestisThymusThyroid glandTonsilUrinary bladderVagina Cell type Expression Antibody panel AnyCiliated cellsKidneyPancreasSalivary glandSertoli cellsSpermatidsSpermatocytesSpermatogonia Tissue Main location Patient ID Annotation Immunoglobulin genesIntracellular and membraneSecreted - unknown locationSecreted in brainSecreted in female reproductive systemSecreted in male reproductive systemSecreted in other tissuesSecreted to bloodSecreted to digestive systemSecreted to extracellular matrix Tissue AnyAdipose tissueAdrenal glandBlood vesselBone marrowBrainBreastCervixChoroid plexusEndometriumEpididymisEsophagusFallopian tubeGallbladderHeart muscleIntestineKidneyLiverLungLymphoid tissueOvaryPancreasParathyroid glandPituitary glandPlacentaProstateRetinaSalivary glandSeminal vesicleSkeletal muscleSkinSmooth muscleStomachTestisThyroid glandTongueUrinary bladderVagina Category Tissue enrichedGroup enrichedTissue enhancedLow tissue specificityNot detectedDetected in allDetected in manyDetected in someDetected in singleIs highest expressed Tau score 0.0-0.10.1-0.20.2-0.30.3-0.40.4-0.50.5-0.60.6-0.70.7-0.80.8-0.90.9-1.0 Cluster 14:Adipose tissue - Angiogenesis4:Adrenal gland - Steroid metabolism15:Bone marrow - Innate immune response44:Bone marrow - Nuclear processes73:Brain - Neuronal signaling78:Brain - Neuronal signaling10:Brain - Synaptic signal transduction65:Brain - Transcription36:Brain & Liver - Signaling46:Brain & retina - Neuronal signaling55:Breast - Lactation71:Cerebellum - Nervous system development27:Cerebellum - Synaptic function1:Choroid plexus - Transmembrane transport48:Ciliated tissues - Cilium organization56:Ciliated tissues - Cilium organization50:Epididymis - Male reproductive secretion22:Epididymis - Mixed function11:Esophagus - Basic cellular processes17:Intestine - Digestion77:Intestine - Digestion72:Kidney - Transmembrane transport26:Kidney & Intestine - Metabolism31:Liver - Metabolism & Coagulation45:Liver - Metabolism & Coagulation53:Liver - Plasma proteins28:Liver & Adrenal gland - Secretion16:Liver & Kidney - Metabolism13:Lung - Secretion34:Lymphoid tissue - Adaptive immune response51:Lymphoid tissue - Adaptive immune response18:Lymphoid tissue - Immune response66:Lymphoid tissue - Immune response59:Lymphoid tissue & Bone marrow - Cell proliferation29:Lymphoid tissue & Bone marrow - Innate immune response25:Non-specific - Basic cellular processes38:Non-specific - Basic cellular processes63:Non-specific - Basic cellular processes68:Non-specific - Basic cellular processes52:Non-specific - Cellular respiration76:Non-specific - Metabolism2:Non-specific - Mixed function35:Non-specific - Mixed function40:Non-specific - Mixed function70:Non-specific - Protein processing54:Non-specific - Ribosome74:Non-specific - Signal transduction24:Non-specific - Transcription49:Non-specific - Transcription61:Non-specific - Transcription64:Non-specific - Transcription3:Oligodendrocytes - Myelination75:Ovary - Mixed function8:Pancreas - Proteolysis69:Parathyroid gland - Mixed function20:Pituitary gland - Hormone signaling43:Placenta - Pregnancy hormone signaling42:Retina - Visual perception32:Retina & Lymphoid tissues - Signaling82:Salivary gland - Secretion62:Skeletal muscle - Muscle contraction19:Skeletal muscle - Striated muscle contraction30:Skeletal muscle - Striated muscle contraction9:Skin - Hair follicle development37:Skin - Keratinization58:Skin - Keratinization7:Small intestine - Absorption and Digestion12:Smooth muscle tissue - ECM organization5:Spleen - Immune response81:Squamous epithelium - Keratinization60:Stomach - Digestion41:Striated muscle - Muscle contraction21:Testis - Mixed function47:Testis - Mixed function67:Testis - Mixed function39:Testis - Nuclear processes6:Testis - Spermatogenesis23:Testis - Spermatogenesis57:Testis - Spermatogenesis79:Testis - Spermatogenesis80:Thymus - Adaptive immune response33:Thyroid gland - Tissue development Reliability EnhancedSupportedApprovedUncertain Brain region AnyAmygdalaBasal gangliaCerebellumCerebral cortexChoroid plexusHippocampal formationHypothalamusMedulla oblongataMidbrainPonsSpinal cordThalamusWhite matter Category Region enrichedGroup enrichedRegion enhancedLow region specificityNot detectedDetected in allDetected in manyDetected in someDetected in singleIs highest expressed Tau score 0.0-0.10.1-0.20.2-0.30.3-0.40.4-0.50.5-0.60.6-0.70.7-0.80.8-0.90.9-1.0 Brain region AnyAmygdalaBasal gangliaCerebellumCerebral cortexHippocampal formationHypothalamusMidbrainOlfactory bulbPons and medullaThalamusWhite matter Category Region enrichedGroup enrichedRegion enhancedLow region specificityNot detectedDetected in allDetected in manyDetected in someDetected in singleIs highest expressed Tau score 0.0-0.10.1-0.20.2-0.30.3-0.40.4-0.50.5-0.60.6-0.70.7-0.80.8-0.90.9-1.0 Brain region AnyAmygdalaBasal gangliaCerebellumCerebral cortexHippocampal formationHypothalamusMedulla oblongataMidbrainOlfactory bulbPonsSpinal cordThalamusWhite matter Category Region enrichedGroup enrichedRegion enhancedLow region specificityNot detectedDetected in allDetected in manyDetected in someDetected in singleIs highest expressed Tau score 0.0-0.10.1-0.20.2-0.30.3-0.40.4-0.50.5-0.60.6-0.70.7-0.80.8-0.90.9-1.0 Cluster 40:Astrocytes - Astrocyte-neuron interactions19:Astrocytes - Mixed function39:Astrocytes - Mixed function46:Brainstem - Mixed function10:Cerebellum - Nucleic acid binding32:Cerebral cortex - Mixed function3:Choroid plexus - Cilium17:Choroid plexus - Cilium42:Choroid plexus - Mitochondria23:Choroid plexus - Mixed function36:Choroid plexus - Mixed function47:Endothelial cells - Vasculature29:Forebrain - Mixed function43:Hindbrain - Mixed function49:Hindbrain - Mixed function56:Hypothalamus - Neuropeptide signaling8:Immune cells - Immune response54:Immune cells - T cell receptor20:Macrophages & Microglia - Immune response41:Monoamines - Neurotransmitter signalling1:Neurons - Mixed function24:Neurons - Mixed function33:Neurons - Mixed function37:Neurons - Mixed function51:Neurons - Mixed function53:Neurons - Mixed function2:Neurons - Nucleosome14:Neurons - Synaptic function52:Neurons & Synapses - Synaptic function35:Non-specific - DNA binding6:Non-specific - Immune response21:Non-specific - Metabolism5:Non-specific - Mixed function18:Non-specific - Mixed function22:Non-specific - Mixed function27:Non-specific - Mixed function34:Non-specific - Mixed function44:Non-specific - Mixed function45:Non-specific - Mixed function48:Non-specific - Mixed function4:Non-specific - mRNA splicing & Cell cycle50:Non-specific - Nucleic acid binding9:Non-specific - Receptor signaling7:Non-specific - Ribosome15:Non-specific - Transcription16:Non-specific - Transcription25:Non-specific - Transcription31:Non-specific - Transcription55:Non-specific - Transcription12:Non-specific - Vasculature13:Oligodendrocytes - Mixed function26:Oligodendrocytes - Mixed function28:Oligodendrocytes - Mixed function38:Sub-cortical - Mixed function30:White matter - Myelination11:White matter - Signal transduction Reliability SupportedApproved Tissue Adipose subcutaneousAdipose visceralAdrenal glandBreastColonHeart muscleKidneyLiverLungMinor Salivary GlandPancreasPituitary glandProstateSkeletal muscleSkinSpleenStomachTestisThyroid gland Cell type Enrichment Cell type AnyAdipocytesAdrenal cortex cellsAdrenal medulla cellsAlveolar cells type 1Alveolar cells type 2AstrocytesB-cellsBasal keratinocytesBasal prostatic cellsBergmann gliaBrain excitatory neuronsBrain inhibitory neuronsBreast hormone-responsive cellsBreast lactating cellsBreast myoepithelial cellsBreast secretory cellsCardiomyocytesCDCCholangiocytesChoroid plexus epithelial cellsColonocytesCone photoreceptor cellsConjunctival goblet cellsCorticotrophsCytotrophoblastsDecidual stromal cellsDifferentiating spermatogoniaDistal convoluted tubule cellsEarly primary spermatocytesEarly spermatidsEndometrial ciliated cellsEndometrial glandular cellsEndometrial luminal cellsEndometrial secretory cellsEndometrial stromal cellsEnteric stem cellsEnteric transient amplifying cellsEnterocytesEpendymal cellsEpicardial cellsEpididymal basal cellsEpididymal clear cellsEpididymal efferent duct absorptive cellsEpididymal efferent duct ciliated cellsEpididymal principal cellsErythrocyte progenitorsErythrocytesEsophageal apical cellsEsophageal basal cellsEsophageal suprabasal cellsExtravillous trophoblastsFallopian secretory cellsFallopian tube ciliated cellsFibro-adipogenic progenitorsFibroblastsFoveolar cellsGastric chief cellsGastric progenitor cellsGoblet cellsGonadotrophsGranulosa cellsHematopoietic stem cellsHepatic stellate cellsHepatocytesHofbauer cellsInnate lymphoid cellsKupffer cellsLacrimal acinar cellsLactotrophsLate primary spermatocytesLate spermatidsLeydig cellsLoop of henle epithelial cellsLymphatic endothelial cellsMacrophagesMast cellsMedullary thymic epithelial cellsMegakaryocyte progenitorsMegakaryocyte-Erythroid progenitorsMegakaryocytesMelanocytesMesothelial cellsMicrogliaMigrating cytotrophoblastsMonocyte progenitorsMonocytesMucous neck cellsMüller gliaMyonucleiMyosatellite cellsNeuroendocrine cellsNeutrophil progenitorsNeutrophilsNK-cellsOcular epithelial cellsOligodendrocyte progenitor cellsOligodendrocytesOocytesOther brain neuronsOvarian stromal cellsPancreatic acinar cellsPancreatic duct cellsPancreatic islet cellsPaneth cellsPapillary tip epithelial cellsParietal cellsPDCsPericytesPeritubular myoid cellsPituicytes/FSCsPituitary stem cellsPlasma cellsPlateletsPodocytesProstatic club cellsProstatic glandular cellsProstatic hillock cellsProximal tubule cellsRenal collecting duct intercalated cellsRenal collecting duct principal cellsRenal connecting tubule cellsRespiratory basal cellsRespiratory ciliated cellsRespiratory deuterosomal cellsRespiratory ionocytesRespiratory secretory cellsRetinal amacrine cellsRetinal bipolar cellsRetinal ganglion cellsRetinal horizontal cellsRetinal pigment epithelial cellsRod photoreceptor cellsSalivary acinar cellsSalivary basal cellsSalivary duct cellsSalivary ionocytesSalivary myoepithelial cellsSchwann cellsSertoli cellsSmooth muscle cellsSomatotrophsSubmucosal glandular cellsSuprabasal keratinocytesSyncytiotrophoblastsT-cellsThymic myoid cellsThymocytesThyrotrophsTransitional alveolar cellsTuft cellsUndifferentiated spermatogoniaUrothelial cellsVascular endothelial cellsVascular smooth muscle cells Category Cell type enrichedGroup enrichedCell type enhancedLow cell type specificityNot detectedDetected in allDetected in manyDetected in someDetected in singleIs highest expressed Tau score 0.0-0.10.1-0.20.2-0.30.3-0.40.4-0.50.5-0.60.6-0.70.7-0.80.8-0.90.9-1.0 Cell type group AnyAcinar cellsAdipocytesAdrenal endocrine cellsAlveolar cellsApical squamous epithelial cellsB-cellsBarrier epithelial cellsBasal cellsCiliated cellsDendritic cellsDuctal cellsEndothelial cellsEnterocytesEnteroendocrine cellsErythrocytesFibro-adipogenic progenitorsFibroblastsGastric glandular cellsGlandular cellsGlial cellsGoblet cellsHepatocytesInnate lymphoid cellsIonocytesLeydig cellsLuminal cellsMast cellsMegakaryocytesMononuclear phagocytesMural cellsMyocytesNeuronal cellsNeutrophilsNK-cellsOocytesPancreatic islet cellsPigment cellsPituitary endocrine cellsPlasma cellsPlateletsProliferating cellsRenal nephron cellsReproductive supporting cellsSecretory cellsSecretory gland supportSmooth muscle cellsSpermatogenic cell typesStellate cellsStem cellsStromal cellsSuprabasal cellsT-cellsTrophoblast cells Category Cell type enrichedGroup enrichedCell type enhancedLow cell type specificityNot detectedDetected in allDetected in manyDetected in someDetected in singleIs highest expressed Tau score 0.0-0.10.1-0.20.2-0.30.3-0.40.4-0.50.5-0.60.6-0.70.7-0.80.8-0.90.9-1.0 Cell type AnyAmygdala excitatoryAstrocyteBergmann gliaCentral nervous system macrophageCerebellar inhibitoryCGE interneuronChoroid plexus epithelial cellCommitted oligodendrocyte precursorDeep-layer corticothalamic and 6bDeep-layer intratelencephalicDeep-layer near-projectingEccentric medium spiny neuronEndothelial cellEpendymal cellFibroblastHippocampal CA1-3Hippocampal CA4Hippocampal dentate gyrusLAMP5-LHX6 and ChandelierLeukocyteLower rhombic lipMammillary bodyMedium spiny neuronMGE interneuronMidbrain-derived inhibitoryMiscellaneousOligodendrocyteOligodendrocyte precursor cellPericyteSplatterThalamic excitatoryUpper rhombic lipUpper-layer intratelencephalicVascular associated smooth muscle cell Category Cell type enrichedGroup enrichedCell type enhancedLow cell type specificityNot detectedDetected in allDetected in manyDetected in someDetected in singleIs highest expressed Tau score 0.0-0.10.1-0.20.2-0.30.3-0.40.4-0.50.5-0.60.6-0.70.7-0.80.8-0.90.9-1.0 Cell type AnyBasophilClassical monocyteEosinophilGdT-cellIntermediate monocyteMAIT T-cellMemory B-cellMemory CD4 T-cellMemory CD8 T-cellMyeloid DCNaive B-cellNaive CD4 T-cellNaive CD8 T-cellNeutrophilNK-cellNon-classical monocytePlasmacytoid DCT-regTotal PBMC Category Immune cell enrichedGroup enrichedImmune cell enhancedLow immune cell specificityNot detected in immune cellsNot detectedDetected in allDetected in manyDetected in someDetected in singleIs highest expressed Tau score 0.0-0.10.1-0.20.2-0.30.3-0.40.4-0.50.5-0.60.6-0.70.7-0.80.8-0.90.9-1.0 Cell lineage AnyB-cellsDendritic cellsGranulocytesMonocytesNK-cellsT-cells Category Lineage enrichedGroup enrichedLineage enhancedLow lineage specificityNot detectedDetected in allDetected in manyDetected in singleIs highest expressed Tau score 0.0-0.10.1-0.20.2-0.30.3-0.40.4-0.50.5-0.60.6-0.70.7-0.80.8-0.90.9-1.0 Cluster 17:B-cells - Immunoglobulins23:B-cells - Immunoglobulins34:B-cells - Unknown function46:Basophils - Proteolysis32:Basophils - Transcription41:Basophils - Unknown function2:Dendritic cells - Unknown function36:Eosinophils - Protein ubiquitination22:Eosinophils - Transcription19:Eosinophils - Unknown function45:Eosinophils - Unknown function40:Monocytes - Innate immune response26:Monocytes - Plasma membrane proteins38:Monocytes & Neutrophils - Degranulation37:Monocytes & Neutrophils - Innate immune response4:Neutrophils - Degranulation35:Neutrophils - Protein binding21:Neutrophils - Unknown function28:Neutrophils - Unknown function15:NK-cells - Unknown function33:Non-specific - ATP binding5:Non-specific - Cell proliferation16:Non-specific - Cell proliferation20:Non-specific - DNA binding30:Non-specific - DNA binding7:Non-specific - Innate immune response10:Non-specific - Membrane trafficking13:Non-specific - Mitochondria12:Non-specific - Mitochondrial translation3:Non-specific - Nuclear processes24:Non-specific - Transcription43:Non-specific - Transcription & Translation18:Non-specific - Translation14:Non-specific - Unknown function25:Non-specific - Unknown function29:Non-specific - Unknown function42:Non-specific - Vesicular transport44:Plasmacytoid DCs - Plasma membrane proteins8:Plasmacytoid DCs - Unknown function6:T-cells - T-cell receptor31:T-cells - T-cell receptor39:T-cells - T-cell receptor1:T-cells - Unknown function11:T-cells - Unknown function27:T-cells - Unknown function9:T-regs - Cell cycle regulation Cluster 89:Adipocytes - Lipid metabolism18:Adrenal cortex cells - Steroidogensis81:Alveolar cells - Lung function84:Apical squamous epithelium - Cornification49:Apical squamous epithelium - Epithelial barrier & keratinization28:Astrocytes - Homeostasis & neuron support87:B-cells - Adaptive immunity: Humoral response104:Brain endothelial cells - Blood brain barrier4:Breast lactating luminal cells - Lactation60:Cardiomyocytes - Cardiac muscle contraction & structure2:Cerebellar granular cells - Neuronal signaling19:Cerebellar purkinje cells - Neurotransmission & signaling101:Choroid plexus epithelial cells - Ion transport34:Ciliated cells - Cilia assembly & function107:Ciliated cells - Cilia assembly & function45:Colonocytes & Enterocytes - Gastrointestinal absorption & barrier63:Cytotrophoblasts - Basic cellular functions82:Dendritic cells - Antigen presentation3:Early primary spermatocytes - Early meiosis42:Early spermatids - Spermiogenesis: Acrosomal phase33:Early spermatids - Spermiogenesis: Cap phase23:Elongating spermatids - Sperm cell metabolism & fertilization90:Elongating spermatids - Spermiogenesis: Elongation12:Endothelial cells - Angiogenesis & vascular homeostasis32:Endothelial cells - Angiogenesis & vascular immunity1:Enterocytes - Absorption and Digestion96:Enteroendocrine cells - Neuropeptide signaling83:Epicardial mesothelial cells - Basic cellular functions10:Epididymal principal cells - Sperm maturation microenvironment30:Epididymal principal cells - Sperm storage microenvironment66:Erythroid cells - Erythroid differentiation and maturation21:Extravillous trophoblasts - Placental invasion & endocrine regulatio108:Fibroblasts - ECM organization68:Foveolar cells - Mucosal defense52:Glandular & Luminal cells - Estrogen-regulated epithelial secretion94:Gonadal somatic cells - Mixed function93:Hepatocytes - Bile production & excretion25:Hepatocytes - Plasma protein synthesis & secretion54:Intestinal epithelial cells - Intestinal epi homeostasis & respiration70:Intestinal goblet cells - Mucin production26:Keratinocytes - Keratinization53:Late primary spermatocytes - Meiotic division & transition77:Late primary spermatocytes - Spermiogenesis: Golgi Phase56:Late spermatids - Spermiogenesis: Maturation73:Late spermatids - Spermiogenesis: Maturation72:Macrophages - Phagocytosis & lysosomal degradation58:Mast cells - Allergic inflammatory responses74:Microglia - Neuroimmunity & neuroinflammation40:Monocytes & Neutrophils - Inflammatory signaling11:Muller glia cells - Retinal homeostasis110:Mural cells - ECM organization55:Myocytes - Oxidative muscle function109:Neurons - Neuronal signaling98:Neurons - Neurotransmission & signaling35:Neurons - Synaptic function & neurogenesis37:Neutrophil progenitors - Granulopoiesis31:Neutrophils - Chemotaxis & Apoptosis29:Neutrophils - Innate immune cellular maintenance24:Neutrophils - Innate immunity signal integration48:Neutrophils - Phagocytosis & degranulation92:NK-cells & T-cells - Adaptive immunity: Cytotoxicity22:Non-specific - Basic cellular functions103:Non-specific - Basic cellular processes71:Non-specific - Cardiac endocrine signaling & maintenanc65:Non-specific - Cell growth & division27:Non-specific - Cell proliferation97:Non-specific - Cellular respiration75:Non-specific - Chaperones and protein folding102:Non-specific - Mixed function105:Non-specific - Mixed function15:Non-specific - Protein processing17:Non-specific - RNA processing8:Non-specific - Secretory pathway7:Non-specific - Transcription20:Non-specific - Transcription regulation14:Oligodendrocyte progenitor cells - Development & myelination80:Oligodendrocytes - Myelination41:Oocytes - Oogenesis5:Pancreatic acinar cells - Pancreatic exocrine secretion76:Pancreatic endocrine cells - Endocrine signaling79:Photoreceptor cells - Phototransduction91:Pituicytes/FSC - Homeostasis & neuron support59:Pituitary endocrine cells - Neuroendocrine signaling78:Plasma cells - Antibody production & ER-stress response44:Plasma cells - Antibody production & secretion67:Plasma cells - Plasma cell differentiation6:Plasmacytoid dendritic cells - Viral sensing & interferon response47:Platelets - Hemostasis57:Podocytes - Glomerular filtration16:Prostatic glandular cells - Androgen response & seminal fluid88:Proximal tubular cells - Transmembrane transport64:Renal epithelial cells - Ion transport & homeostasis50:Renal epithelial cells - Ion transport and pH regulation86:Retinal bipolar cells - Synaptic signal transduction99:Retinal pigment epithelial cells - Retinol metabolism61:Schwann cells & Melanocytes - Mixed function38:Secretory epithelial cells - Exocrine secretion51:Secretory epithelial cells - Mixed function43:Sertoli cells - Spermatogenesis microenvironment36:Skeletal myocytes - Muscle excitation & contraction46:Skeletal myocytes - Muscle structure & formation62:Smooth muscle cells - Muscle contraction106:Spermatogonia - Spermatogonial differentiation85:Squamous epithelial cells - Keratinization100:Stratified epithelial cells - Barrier functions39:Syncytiotrophoblasts - Placental homeostasis & endocrine signal13:Syncytiotrophoblasts - Placental remodeling & endocrine func.9:T-cells - Adaptive immunity: Regulation95:Tuft cells - Chemosensory signaling69:Urothelial cells - Basic cellular functions Location AcrosomeActin filamentsAggresomeAnnulusBasal bodyCalyxCell JunctionsCentriolar satelliteCentrosomeCleavage furrowConnecting pieceCytokinetic bridgeCytoplasmic bodiesCytosolEnd pieceEndoplasmic reticulumEndosomesEquatorial segmentFlagellar centrioleFocal adhesion sitesGolgi apparatusIntermediate filamentsKinetochoreLipid dropletsLysosomesMicrotubule endsMicrotubulesMid pieceMidbodyMidbody ringMitochondriaMitotic chromosomeMitotic spindleNuclear bodiesNuclear membraneNuclear specklesNucleoliNucleoli fibrillar centerNucleoli rimNucleoplasmPerinuclear thecaPeroxisomesPlasma membranePrimary ciliumPrimary cilium tipPrimary cilium transition zonePrincipal pieceRods & RingsVesicles Searches EnhancedSupportedApprovedUncertainSingle cell variationCCD protein mitotic structureCCD protein interphaseCell cycle dependent proteinCell cycle independent proteinCell cycle dependent transcriptCell cycle independent transcriptMultilocalizingLocalizing 1Localizing 2Localizing 3Localizing 4Localizing 5Localizing 6Main locationAdditional location Location AnyAcrosomeActin filamentsAggresomeAnnulusBasal bodyCalyxCell JunctionsCentriolar satelliteCentrosomeCleavage furrowConnecting pieceCytokinetic bridgeCytoplasmic bodiesCytosolEnd pieceEndoplasmic reticulumEndosomesEquatorial segmentFlagellar centrioleFocal adhesion sitesGolgi apparatusIntermediate filamentsKinetochoreLipid dropletsLysosomesMicrotubule endsMicrotubulesMid pieceMidbodyMidbody ringMitochondriaMitotic chromosomeMitotic spindleNuclear bodiesNuclear membraneNuclear specklesNucleoliNucleoli fibrillar centerNucleoli rimNucleoplasmPerinuclear thecaPeroxisomesPlasma membranePrimary ciliumPrimary cilium tipPrimary cilium transition zonePrincipal pieceRods & RingsVesicles Cell line AnyA-431A-549AF22ASC52teloBJ [Human fibroblast]CACO-2EFO-21GAMGHaCaTHAP1HBEC3-KTHDLM-2HEK293HELHeLaHep-G2HTCEpiHTERT-RPE1HTERT-RPE1 (serum starved)HUVEC/TERT2JURKATK-562KOLF2.1JLHCN-M2MCF-7NB4OE19PC-3PODO/SVTERT152PODO/TERT256REHRh30RPTEC/TERT1RT-4SH-SY5YSiHaSK-MEL-30SpermSuSaTHP-1U-251MGU2OS Class Predicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins Type ProteinRna Phase G1SG2 Reliability EnhancedSupportedApprovedUncertain Cancer Bladder Urothelial CarcinomaBreast Invasive CarcinomaCervical Squamous Cell Carcinoma and Endocervical AdenocarcinomaColon AdenocarcinomaGlioblastoma MultiformeHead and Neck Squamous Cell CarcinomaKidney ChromophobeKidney Renal Clear Cell CarcinomaKidney Renal Papillary Cell CarcinomaLiver Hepatocellular CarcinomaLung AdenocarcinomaLung Squamous Cell CarcinomaOvary Serous CystadenocarcinomaPancreatic AdenocarcinomaProstate AdenocarcinomaRectum AdenocarcinomaSkin Cutaneous MelanomaStomach AdenocarcinomaTesticular Germ Cell TumorThyroid CarcinomaUterine Corpus Endometrial Carcinoma Prognosis Favorable - potential prognosticFavorable - validated prognosticUnfavorable - potential prognosticUnfavorable - validated prognostic Cancer AnyBladder Urothelial CarcinomaBreast Invasive CarcinomaCervical Squamous Cell Carcinoma and Endocervical AdenocarcinomaColon AdenocarcinomaGlioblastoma MultiformeHead and Neck Squamous Cell CarcinomaKidney ChromophobeKidney Renal Clear Cell CarcinomaKidney Renal Papillary Cell CarcinomaLiver Hepatocellular CarcinomaLung AdenocarcinomaLung Squamous Cell CarcinomaOvary Serous CystadenocarcinomaPancreatic AdenocarcinomaProstate AdenocarcinomaRectum AdenocarcinomaSkin Cutaneous MelanomaStomach AdenocarcinomaTesticular Germ Cell TumorThyroid CarcinomaUterine Corpus Endometrial Carcinoma Category Cancer enrichedGroup enrichedCancer enhancedLow cancer specificityNot detectedDetected in allDetected in manyDetected in someDetected in singleIs highest expressed Cancer AnyAdrenocortical cancerBile duct cancerBladder cancerBone cancerBrain cancerBreast cancerCervical cancerColorectal cancerEsophageal cancerGallbladder cancerGastric cancerHead and neck cancerKidney cancerLeukemiaLiver cancerLung cancerLymphomaMyelomaNeuroblastomaNon-cancerousOvarian cancerPancreatic cancerProstate cancerRhabdoidSarcomaSkin cancerTestis cancerThyroid cancerUncategorizedUterine cancer Category Cancer enrichedGroup enrichedCancer enhancedLow cancer specificityNot detectedDetected in allDetected in manyDetected in someDetected in singleIs highest expressed Tau score 0.0-0.10.1-0.20.2-0.30.3-0.40.4-0.50.5-0.60.6-0.70.7-0.80.8-0.90.9-1.0 Cluster 48:Adipocytes & Endothelial cells - Angiogenesis61:BICR 18 - Protein kinases12:Bone cancer - Neuronal signaling27:Breast cancer - Unknown function10:Ciliated cells - Ion channel activity44:Connective tissue cells - ECM organization64:Connective tissue cells - ECM organization70:DU4475 - Unknown function49:HMC-1 - Innate immune response15:Kidney cancer - Membrane components47:Leukemia - Hemostasis6:Leukemia - Signal transduction59:Leukemia - T-cell receptor7:Liver cancer - Metabolism18:Liver cancer - Metabolism21:Lymphoma - Adaptive immune response46:Lymphoma - Humoral immune response55:Lymphoma - Immune response71:Lymphoma - Inflammatory response50:Lymphoma - Unknown function2:Mucus-secreting cells - Unknown function14:Myeloid leukemia - Innate immune response20:Myeloma - Immune response51:Myeloma - Immunoglobulins17:Neuroblastoma - Neuronal signaling11:Neuronal - Sensory perception72:Neuronal - Signal transduction1:Neuronal - Visual perception31:Non-specific - Antiviral immune response8:Non-specific - Basic cellular processes43:Non-specific - Basic cellular processes68:Non-specific - Cell cycle regulation32:Non-specific - Cell proliferation30:Non-specific - Gene expression regulation52:Non-specific - Mitochondria66:Non-specific - Mitochondria26:Non-specific - Mitochondria & RNA binding13:Non-specific - Mixed function36:Non-specific - mRNA processing37:Non-specific - mRNA processing22:Non-specific - mRNA splicing & Cell cycle28:Non-specific - Nuclear processes45:Non-specific - Nuclear processes58:Non-specific - Nuclear processes41:Non-specific - Nucleosome assembly62:Non-specific - Plasma proteins63:Non-specific - Protein processing25:Non-specific - Ribosome56:Non-specific - Sensory perception4:Non-specific - Transcription23:Non-specific - Transcription38:Non-specific - Transcription39:Non-specific - Transcription54:Non-specific - Transcription19:Non-specific - Unknown function24:Non-specific - Unknown function29:Non-specific - Unknown function40:Non-specific - Unknown function42:Non-specific - Unknown function65:Non-specific - Unknown function67:Non-specific - Unknown function60:Prostate cancer - Unknown function3:Rhabdoid - Membrane components5:Rhabdoid - Unknown function35:RS4;11 - Unknown function33:Sarcoma - Muscle contraction69:Skin cancer - ECM organization9:Skin cancer - Melanin biosynthesis53:Squamous epithelial cells - Keratinization57:Stomach & Colon cancer - Digestion34:Testis cancer - Unknown function16:Thyroid cancer - Neuronal signaling Variants Alphamissense populationAlphamissense clinicalExperimental PopulationExperimental clinical Interacting gene (ensg_id) Type ConsensusIntActBioGridOpenCellBioPlex Number of interactions 123456-1011-2021-3031-4041-5051-7576-100101-200>200 Pathway Acyl-CoA hydrolysisAcylglycerides metabolismAlanine; aspartate and glutamate metabolismAmino sugar and nucleotide sugar metabolismAminoacyl-tRNA biosynthesisAndrogen metabolismArachidonic acid metabolismArginine and proline metabolismAscorbate and aldarate metabolismBeta oxidation of branched-chain fatty acids (mitochondrial)Beta oxidation of di-unsaturated fatty acids (n-6) (mitochondrial)Beta oxidation of di-unsaturated fatty acids (n-6) (peroxisomal)Beta oxidation of even-chain fatty acids (mitochondrial)Beta oxidation of even-chain fatty acids (peroxisomal)Beta oxidation of odd-chain fatty acids (mitochondrial)Beta oxidation of phytanic acid (peroxisomal)Beta oxidation of poly-unsaturated fatty acids (mitochondrial)Beta oxidation of unsaturated fatty acids (n-7) (mitochondrial)Beta oxidation of unsaturated fatty acids (n-7) (peroxisomal)Beta oxidation of unsaturated fatty acids (n-9) (mitochondrial)Beta oxidation of unsaturated fatty acids (n-9) (peroxisomal)Beta-alanine metabolismBile acid biosynthesisBile acid recyclingBiopterin metabolismBiotin metabolismBlood group biosynthesisButanoate metabolismC5-branched dibasic acid metabolismCarnitine shuttle (cytosolic)Carnitine shuttle (endoplasmic reticular)Carnitine shuttle (mitochondrial)Carnitine shuttle (peroxisomal)Cholesterol biosynthesis 1 (Bloch pathway)Cholesterol biosynthesis 2Cholesterol biosynthesis 3 (Kandustch-Russell pathway)Cholesterol metabolismChondroitin / heparan sulfate biosynthesisChondroitin sulfate degradationCysteine and methionine metabolismDrug metabolismEicosanoid metabolismEstrogen metabolismEther lipid metabolismFatty acid activation (cytosolic)Fatty acid activation (endoplasmic reticular)Fatty acid biosynthesisFatty acid biosynthesis (even-chain)Fatty acid biosynthesis (odd-chain)Fatty acid biosynthesis (unsaturated)Fatty acid degradationFatty acid desaturation (even-chain)Fatty acid desaturation (odd-chain)Fatty acid elongation (even-chain)Fatty acid elongation (odd-chain)Fatty acid metabolismFatty acid oxidationFolate metabolismFormation and hydrolysis of cholesterol estersFructose and mannose metabolismGalactose metabolismGlucocorticoid biosynthesisGlutathione metabolismGlycerolipid metabolismGlycerophospholipid metabolismGlycine; serine and threonine metabolismGlycolysis / GluconeogenesisGlycosphingolipid biosynthesis-ganglio seriesGlycosphingolipid biosynthesis-globo seriesGlycosphingolipid biosynthesis-lacto and neolacto seriesGlycosphingolipid metabolismGlycosylphosphatidylinositol (GPI)-anchor biosynthesisGlyoxylate and dicarboxylate metabolismHeme degradationHeparan sulfate degradationHistidine metabolismInositol phosphate metabolismInsect hormone biosynthesisIsolatedKeratan sulfate biosynthesisKeratan sulfate degradationLeukotriene metabolismLinoleate metabolismLipoic acid metabolismLysine metabolismMetabolism of other amino acidsMiscellaneousN-glycan metabolismNicotinate and nicotinamide metabolismNucleotide metabolismO-glycan metabolismOctane oxidationOmega-3 fatty acid metabolismOmega-6 fatty acid metabolismOxidative phosphorylationPantothenate and CoA metabolismPentose and glucuronate interconversionsPentose phosphate pathwayPhenylalanine metabolismPhenylalanine; tyrosine and tryptophan biosynthesisPhosphatidylinositol phosphate metabolismPool reactionsPorphyrin metabolismPropanoate metabolismProstaglandin biosynthesisProtein assemblyProtein degradationProtein modificationPurine metabolismPyrimidine metabolismPyruvate metabolismRetinol metabolismRiboflavin metabolismROS detoxificationSerotonin and melatonin biosynthesisSphingolipid metabolismStarch and sucrose metabolismSteroid metabolismSulfur metabolismTerpenoid backbone biosynthesisThiamine metabolismToluene degradationTransport reactionsTricarboxylic acid cycle and glyoxylate/dicarboxylate metabolismTryptophan metabolismTyrosine metabolismUbiquinone and other terpenoid-quinone biosynthesisUbiquinone synthesisValine; leucine; and isoleucine metabolismVitamin A metabolismVitamin B12 metabolismVitamin B2 metabolismVitamin B6 metabolismVitamin C metabolismVitamin D metabolismVitamin E metabolismXenobiotics metabolism ipTM 0-0.20.2-0.40.4-0.60.6-0.80.8-1 Category Evidence at protein levelEvidence at transcript levelNo human protein/transcript evidence Category Evidence at protein levelEvidence at transcript levelNo human protein/transcript evidence Category Evidence at protein levelEvidence at transcript levelNo human protein/transcript evidence Category Evidence at protein levelEvidence at transcript levelNo human protein/transcript evidence Validation SupportedApprovedUncertain Validation Enhanced - CaptureEnhanced - GeneticEnhanced - IndependentEnhanced - OrthogonalEnhanced - RecombinantSupportedApprovedUncertain Validation Enhanced - IndependentEnhanced - OrthogonalSupportedApprovedUncertain Validation Enhanced - GeneticEnhanced - IndependentEnhanced - RecombinantSupportedApprovedUncertain Antibodies YesNo Data type Tissue - ImmunohistochemistryTissue - GTEx transcriptomicsTissue - FANTOM transcriptomicsTissue - Expression clusteringBrainBrain - Expression clusteringSingle cell - Expression clusteringImmune cell - Expression clusteringSubcellularCancer - ImmunohistochemistryCancer - Mass spectrometryBlood - conc. immunoassayBlood - conc. mass spectrometryBlood - Olink HTBlood - Olink 1536Blood - SomaScanBlood - ProteomEdgeBlood - Targeted proteomicsCell line - Mass spectrometryCell line - Expression clusteringStructureInteractionMetabolic Column GenePositionTissue specific scorePrognosticReliability (IF)Reliability (IH) Add Cancel
Cell linesHematopoietic cell linesCell lines
Name Description of cell line Original reference Origin Sex & Age Source Cellosaurus (ExPaSy)

Brain

SH-SY5Y Metastatic neuroblastoma, clonal subline of neuroepithelioma cell line SK-N-SH Biedler et al., Cancer Res 33: 2643 (1973) Bone marrow Female, 4 DSMZ CVCL_0019Cancer cell line
AF22 iPS derived Neuroepithelia stem (NES) cell line Falk et al., PLoS One 7(1) (2012) Skin Female, 36 NA Uncategorised
U-251MG Glioblastoma cell line Westermark B., Int J Cancer12: 438 (1973) Brain Male BW1 CVCL_0021Cancer cell line
GAMG Glioblastoma cell line Akslen et al, Anticancer Res. 8(4): 797-803 (1988) Female, 42 DSMZ CVCL_1226Cancer cell line

Eye

HTERT-RPE1 Retinal pigment epithelial cells immortalized with hTERT Rambhatla L et al.. Invest Ophthalmol Vis Sci. 43(5):1622-30. (2002) Retina, eye Female, 1 CVCL_4388Telomerase immortalized cell line
HTCEpi Telomerase-immortalized corneal epithelial cell line Robertson et al., Invest Ophthalmol Vis Sci 46(2): 470-478 (2005) Cornea Male, 62 Evercyte CVCL_AQ44Telomerase immortalized cell line
HTERT-RPE1 (serum starved) Retinal pigment epithelial cells immortalized with hTERT Rambhatla L et al.. Invest Ophthalmol Vis Sci. 43(5):1622-30. (2002) Retina, eye Female, 1 CVCL_4388Telomerase immortalized cell line

Proximal digestive tract

OE19 Esophageal adenocarcinoma cell line PMID: 9010035 Esophagus Male, 72 DSMZ CVCL_1622Cancer cell line

Gastrointestinal tract

CACO-2 Colon adenocarcinoma cell line Fogh J., et al. J. Natl. Cancer Inst. 58: 209 (1977) Colon Male, 72 DSMZ CVCL_0025Cancer cell line

Liver & Gallbladder

Hep-G2 Hepatocellular carcinoma cell line Aden et al., Nature 282: 615 (1979) Liver Male, 15 DSMZ CVCL_0027Cancer cell line

Kidney & Urinary bladder

RPTEC/TERT1 Proximal tubular epithelial cell line Wieser et al., Am J Physiol Renal Physiol 295(5): 1365-1375 (2008) Human kidney cortex Male Evercyte CVCL_K278Telomerase immortalized cell line
RT-4 Urinary bladder transitional cell carcinoma cell line Rigby et al., Br J Cancer 24: 746 (1970) Urinary bladder Male, 63 DSMZ/ECACC CVCL_0036Cancer cell line
HEK293 Embryonal kidney cell line, transformed by adenovirus type 5 Graham et al., J Gen Virol 36: 59 (1977) Embryonal kidney Female DSMZ CVCL_0045Transformed cell line

Male reproductive system

Sperm Male Uncategorised
SuSa Testicular germ cell tumor PMID: 593370 Testis Male, 30 DSMZ CVCL_L280Cancer cell line
PC-3 Metastatic poorly differentiated prostate adenocarcinoma cell line Kaighn et al., Invest Urol 17: 16-23 (1979) Bone marrow Male, 62 DSMZ CVCL_0035Cancer cell line

Skin

SK-MEL-30 Metastatic malignant melanoma cell line Carey et al., Proc Natl Acad Sci USA 73: 3278 (1976) Subcutis Male, 67 DSMZ CVCL_0039Cancer cell line
A-431 Epidermoid carcinoma cell line Giard et al., J Natl Cancer Inst 51: 1417 (1973) Skin Female, 85 DSMZ CVCL_0037Cancer cell line
HaCaT Keratinocyte cell line Boukamp et al., J Cell Biol Mar 106(3): 761 (1988) Skin Male NEF2 CVCL_0038Spontaneously immortalized cell line

Lung

HBEC3-KT Immortalized human bronchial epithelial cell line Central lung bronchiole Female, 65 Evercyte CVCL_X491Telomerase immortalized cell line
A-549 Lung carcinoma cell line Giard et al., J Natl Cancer Inst 51: 1417 (1973) Lung Male, 58 DSMZ CVCL_0023Cancer cell line

Female reproductive system

HeLa Cervical epithelial adenocarcinoma cell line Scherer et al., J Exp Med 97: 695 (1953) Cervix Female, 31 DSMZ CVCL_0030Cancer cell line
MCF-7 Metastatic breast adenocarcinoma cell line Soule et al., J Natl Cancer Inst 51: 1409 (1973) Pleural effusion Female, 69 DSMZ CVCL_0031Cancer cell line
SiHa Cervical squamous cell carcinoma cell line, integrated 1-2 copies of HPV16 Friedl F. et al.Proc., Soc. Exp. Biol. Med. 135: 543-545 (1970) Cervix Female, 55 LGC/ATCC CVCL_0032Cancer cell line
EFO-21 Metastatic ovarian serous cystadenocarcinoma cell line Simon et al., J Natl Cancer Inst 70: 839 (1983) Ascites Female, 56 DSMZ CVCL_0029Cancer cell line

Endothelial

HUVEC/TERT2 Umbilical vein endothelial cell line NA Umbilical vein Female Evercyte CVCL_9Q53Telomerase immortalized cell line

Mesenchymal

LHCN-M2 Adherent myoblast cell line Zhu et al., Aging Cell 6(4): 515-523 (2007) Satellite cells (from pectoralis major muscle) Male, 41 Evercyte CVCL_8890Telomerase immortalized cell line
U2OS Osteosarcoma cell line Ponten J., Saksela E. Int. J. Cancer 2: 434 (1967) Bone Female, 15 LGC/ATCC CVCL_0042Cancer cell line
Rh30 Metastatic rhabdomyosarcoma cell line Douglass et al., Cytogenet Cell Genet 45: 148-155 (1987) Bone marrow Male, 17 DSMZ CVCL_0041Cancer cell line
BJ [Human fibroblast] Adherent fibroblast cell line Bodnar AG., et al. Science 279: 349-352 (1998) Foreskin Male LGC/ATCC CVCL_3653Finite cell line
ASC52telo Adipose tissue-derived mesenchymal stem cell line Wolbank S. et al., Tissue Eng Part A: Jul;15(7):1843-54 (2009) Adipose tissue Female Evercyte CVCL_U602Telomerase immortalized cell line

Lymphoid

REH** Pre-B cell leukemia cell line (ALL, first relapse) Rosenfeld et al., Nature 267: 841–3 (1977) Peripheral blood Female, 15 DSMZ CVCL_1650Cancer cell line
JURKAT T-cell leukemia cell line Peripheral blood Male, 14 DSMZ CVCL_0065Cancer cell line
HDLM-2 Hodgkin lymphoma cell line Drexler et al., Leuk Res 10: 487 (1986) Pleural effusion Male, 74 DSMZ CVCL_0009Cancer cell line

Myeloid

NB4 Acute promyelocytic leukemia (APL) cell line Lanotte et al., Blood 77: 1080 (1991) Bone marrow Female, 23 DSMZ CVCL_0005Cancer cell line
K-562 Chronic myeloid leukemia (CML) cell line Lozzio et al., J Natl Cancer Inst 50: 535 (1973) Pleural effusion Female, 53 DSMZ CVCL_0004Cancer cell line
HEL Erythroleukemia cell line (AML M6 in relapse after treatment for Hodgkin's disease) Martin et al., Science 216: 1233 (1982) Peripheral blood Male, 30 DSMZ CVCL_0001Cancer cell line
THP-1 Acute monocytic leukemia (AML) cell line Tsuchiya et al., Int J Cancer 26: 171 (1980) Peripheral blood Male, 1 DSMZ CVCL_0006Cancer cell line
HAP1 Haploid karyotype cell line from Chronic myelogenous leukemia Carette et al., Nature 477(7364): 340-343 (2011) Leukemia Male Horizon Discovery CVCL_Y019Cancer cell line

Stem cells

KOLF2.1J 36459969 Male, 55 Uncategorised

Renal, urinary, male reproductive system

PODO/TERT256 Female Evercyte CVCL_JL76
PODO/SVTERT152 Urine visceral epithelial cells Male, 41 Evercyte CVCL_B5ST

Mouse

NIH 3T3 Mouse embryonal fibroblast cell line Aaronson et al., J Cell Physio 72(2): 141-148 (1968) Embryo DSMZ CVCL_0594Spontaneously immortalized cell line

Notes

* Allen M, Bjerke M, Edlund H, Nelander S and Westermark B: Origin of the U87MG glioma cell line: Good news and bad news. Science Translational Medicine 31 Aug 2016: Vol. 8, Issue 354, pp. 354. DOI: 10.1126/scitranslmed.aaf6853 ** REH was previously listed as KM3. Due to misidentification, KM3 has been deleted from the DSMZ catalogue and the true identity is REH. DSMZ - False leukemia and lymphoma cell lines. Drexler et al., False leukemia-lymphoma cell lines: An update on over 500 cell lines. Leukemia 17: 416-426 (2003)

Source information

  1. Prof. Bengt Westermark, Uppsala University, Uppsala, Sweden
  2. Prof. Norbert E Fusenig, DKFZ, Heidelberg, Germany

Hematopoietic cell lines

Schematic description of hematopoietic differentiation lineages, and cellular origin for hematopoietic cell lines.

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