Relationship Of High CH50 Level And Interruption Of Cascade Reaction ...

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Abstract

In patients with pulmonary embolism (PE), forepart components of complements were activated. However there are interruption/decrease of cascade reaction and cytolytic effects in complement system. This study detected CRP, CH50, C3 and C4 levels in patients with venous thromboembolism (VTE) and compare with the imbalance of complement associated gene mRNA expression in PE patients. There was significant increase of CH50 in acute VTE patients. Even though CH50 increased significantly in acute VTE patients and had a relatively high sensitivity, cytolytic effects of complements might decrease, based on the genomics results of complement cascade reactions imbalance/interruption and increased total complements in VTE patients.

Keywords: CH50; complement; pulmonary embolism.

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Figures

Figure 1

Figure 1

A. Compared with normal range,…

Figure 1

A. Compared with normal range, CRP increased significantly in VTE patients. Density curve…

Figure 1 A. Compared with normal range, CRP increased significantly in VTE patients. Density curve of VTE patients was flatter and shifted to the right significantly (P < 0.01). B. Compared with normal range, CH50 increased and density curve shifted to the right significantly in VTE patients (P < 0.01). C. C3 was almost within the normal range and density curve shifted slightly to the left in VTE patients. D. C4 was almost within the normal range and density curve shifted slightly to the right in VTE patients.
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References

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