Suppressor T Cell Memory. Induction And Recall Of HGG-specific ...

Trang chủ » Hgg T » Suppressor T Cell Memory. Induction And Recall Of HGG-specific ...

Có thể bạn quan tâm

Clipboard, Search History, and several other advanced features are temporarily unavailable. Skip to main page content Dot gov

The .gov means it’s official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation pubmed logo Search: Search Advanced Clipboard User Guide Save Email Send to
  • Clipboard
  • My Bibliography
  • Collections
  • Citation manager
Display options Display options Format Abstract PubMed PMID

Save citation to file

Format: Summary (text) PubMed PMID Abstract (text) CSV Create file Cancel

Email citation

Subject: 1 selected item: 6204629 - PubMed To: From: Format: Summary Summary (text) Abstract Abstract (text) MeSH and other data Send email Cancel

Add to Collections

  • Create a new collection
  • Add to an existing collection
Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error Please try again Add Cancel

Add to My Bibliography

  • My Bibliography
Unable to load your delegates due to an error Please try again Add Cancel

Your saved search

Name of saved search: Search terms: Test search terms Would you like email updates of new search results? Saved Search Alert Radio Buttons
  • Yes
  • No
Email: (change) Frequency: Monthly Weekly Daily Which day? The first Sunday The first Monday The first Tuesday The first Wednesday The first Thursday The first Friday The first Saturday The first day The first weekday Which day? Sunday Monday Tuesday Wednesday Thursday Friday Saturday Report format: Summary Summary (text) Abstract Abstract (text) PubMed Send at most: 1 item 5 items 10 items 20 items 50 items 100 items 200 items Send even when there aren't any new results Optional text in email: Save Cancel

Create a file for external citation management software

Create file Cancel

Your RSS Feed

Name of RSS Feed: Number of items displayed: 5 10 15 20 50 100 Create RSS Cancel RSS Link Copy

Actions

CiteCollectionsAdd to Collections
  • Create a new collection
  • Add to an existing collection
Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an errorPlease try again Add Cancel Display options Display options Format AbstractPubMedPMID

Share

  • Permalink Copy

Page navigation

  • Title & authors
  • Abstract
  • Similar articles
  • Cited by
  • Publication types
  • MeSH terms
  • Substances
  • LinkOut - more resources
Title & authors Abstract Similar articles Cited by Publication types MeSH terms Substances LinkOut - more resources CiteDisplay options Display options Format AbstractPubMedPMID

Abstract

Regulation of the antibody response to the hapten, dinitrophenyl (DNP), was studied using human gammaglobulin (HGG) as the carrier in an adoptive transfer system. CBA mice immunized at least 4 weeks previously to HGG or DNP served as the source of T helper cells and hapten-primed B cells, respectively. The addition of spleen cells from donors recently primed to HGG in immunogenic form (aHGG) suppressed the collaborative anti-DNP PFC response as effectively as cells from tolerant donors. The suppressive effect was antigen-specific and was mediated by a T cell with the same phenotype (Ly-1-, Ly-23+, Ia+) and induction kinetics as those previously identified in HGG-tolerant animals. During the primary response to HGG an early burst of helper activity was detected initially, followed by a wave of suppression which peaked at day 7 and subsequently waned, allowing adoptive helper function to reappear during the third week. When previously immunized animals were boosted with soluble HGG after primary suppression had waned, the sequential appearance of helper and suppressor activity was accelerated, and the secondary suppressive effect was more profound and of longer duration than that observed during a primary response. Although helper activity was not apparent during the peak of secondary suppression, helper T cells (Th) had not been functionally deleted since treatment of the donor spleen cells with anti-Ia and complement to deplete suppressor T cells (Ts) before adoptive transfer resulted in significant augmentation of the anti-DNP response. The secondary suppressive effect was formally shown to be mediated by activated Ts effector cells bearing the same surface markers as the cells responsible for primary suppression. The results suggest that the Ts population, like other lymphocyte subsets, contain memory cells capable of rapid reexpression of effector function upon secondary exposure to antigen. These cells are considered to be of a major importance in maintenance of immune homeostasis.

PubMed Disclaimer

Similar articles

  • Suppressor T cell memory. II. The role of memory suppressor T cells in tolerance to human gamma globulin. Loblay RH, Fazekas de St Groth B, Pritchard-Briscoe H, Basten A. Loblay RH, et al. J Exp Med. 1983 Mar 1;157(3):957-73. doi: 10.1084/jem.157.3.957. J Exp Med. 1983. PMID: 6187882 Free PMC article.
  • Regulation of anti-hapten antibody responses in vivo: memory, carrier-specific Lyt-2+ T cells can terminate antibody production without altering the peak of response. Kanellopoulos-Langevin C, Mathieson BJ, Perkins A, Maynard A, Asofsky R. Kanellopoulos-Langevin C, et al. J Immunol. 1984 Apr;132(4):1639-46. J Immunol. 1984. PMID: 6199405
  • Regulatory functions of hapten-reactive helper and suppressor T lymphocytes. I. Detection and characterization of hapten-reactive suppressor T-cell activity in mice immunized with hapten-isologous protein conjugate. Yamamoto H, Hamaoka T, Yoshizawa M, Kuroki M, Kitagawa M. Yamamoto H, et al. J Exp Med. 1977 Jul 1;146(1):74-90. doi: 10.1084/jem.146.1.74. J Exp Med. 1977. PMID: 68994 Free PMC article.
  • Control of isotype expression by helper T-cell clones and suppressor cells. Thèze J, Löwy I, Seman M, Brézin C, Neauport-Sautes C, Fridman WH. Thèze J, et al. Ann Immunol (Paris). 1983 Jul-Aug;134D(1):55-61. doi: 10.1016/s0769-2625(83)80056-7. Ann Immunol (Paris). 1983. PMID: 6226238 Review.
  • What roles do regulatory T cells play in the control of the adaptive immune response? Cohn M. Cohn M. Int Immunol. 2008 Sep;20(9):1107-18. doi: 10.1093/intimm/dxn088. Epub 2008 Jul 25. Int Immunol. 2008. PMID: 18658168 Free PMC article. Review.
See all similar articles

Cited by

  • Special regulatory T-cell review: T-cell dependent suppression revisited. Basten A, Fazekas de St Groth B. Basten A, et al. Immunology. 2008 Jan;123(1):33-9. doi: 10.1111/j.1365-2567.2007.02772.x. Immunology. 2008. PMID: 18154617 Free PMC article. Review.

Publication types

  • Research Support, Non-U.S. Gov't Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search

MeSH terms

  • Animals Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Antibody Formation* Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Antibody-Producing Cells / immunology Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Chorionic Gonadotropin / immunology Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Female Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Immunologic Memory* Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Kinetics Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Male Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Mice Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Mice, Inbred CBA Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Phenotype Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Spleen / cytology Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • T-Lymphocytes, Helper-Inducer / immunology Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • T-Lymphocytes, Regulatory / immunology* Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • gamma-Globulins / immunology* Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search

Substances

  • Chorionic Gonadotropin Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • gamma-Globulins Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search

LinkOut - more resources

  • Other Literature Sources

    • The Lens - Patent Citations Database

  • Miscellaneous

    • NCI CPTAC Assay Portal
[x] Cite Copy Download .nbib .nbib Format: AMA APA MLA NLM Send To
  • Clipboard
  • Email
  • Save
  • My Bibliography
  • Collections
  • Citation Manager
[x]

NCBI Literature Resources

MeSH PMC Bookshelf Disclaimer

The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.

Từ khóa » Hgg T