Table 5-4, Agents That May Affect TSH Secretion - Endotext - NCBI

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Table 5-4Agents that May Affect TSH Secretion

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Substance Common Use
Increase serum TSH concentration and/or its response to TRH
Iodine (iodide and iodine-containing compounds)aRadiologic contrast media, antiseptic expectorants, antiarrhymic and antianginal agents
LithiumaTreatment of bipolar psychoses
Dopamine receptor lockers (metclopramide,252,253 domperidone253 254)Antiemetic
Dopamine-blocking agent(sulpiride255 )Tranquilizer
Decarboxylase inhibitor (benserazide256)–
Dopamine-depleting agent(monoiodotyrosine253)–
L-Dopa inhibitors(chloropromazine,257 biperidine,258 haloperidol258)Neuroleptic drugs
Cimetidine (histamine receptor blocker)259Treatment of peptic ulcers
Clomifene (antiestrogen)260Induction of ovulation
Spironolactone261Antihypertensive agent
Amphetamines262Anticongestants and antiappetite
Decrease serum TSH concentration and/or its response to TRH
Thyroid hormones (T4 and T3)Replacement therapy, antigoitrogenic and anticancer agents
Thyroid hormone analogs (D-T4,263 3,3',5-Triac,264 etiroxate-HCl,265 3,5-dimethyl-3-isopropyl-L-thyronine266)Cholesterol-lowering and weight reducing agents
Dopaminergic agents (agonists)
DopamineaAntihypotensive agent
L-Dopaa (dopamine precursor)Diagnostic and anti-Parkinsonian agent
2-Brom-alpha-ergocryptineaAntilactation and pituitary tumor suppressive agent
Fusaric acid (inhibitor of dopamine ß-hydroxylase267)–
Pyridoxine (coenzyme of dopamine synthesis268)Vitamin and antiheuropathic agent
Other dopaminergic agents (perbidil,269 apomorphine,269 lisuride270 )Treatment of cerebrovascular diseases and migraine
Dopamine antagonist (pimozide)aNeuroleptic agent
alpha-Noradrenergic blockers (phentolamine,271 thioridazine272)Neuroleptic agents
Serotonin antagonists metergoline,273 cyroheptadine,274 methysergide275)Antimigraine agents and appetite stimulators
Serotonin agonist(5-hydroxytryptophan276)–
Glucocorticoidsa Antiinflammatory, immunosuppressive, and anticancer agents. Reduction of intracranial pressure
Acetylsalicylic acidaAntiinflammatory, antipyrexic and analgesic agent
Growth hormone277 b Growth-promoting agent
Somatostatin278,279 –
Octreotide 279aTreatment of carcinoids, acromegaly and other secretory tumors
Opiates (morphine,280 leucine- eukephaline,281 heroin282)Analgesic agents
Clofibrate283Hypolipemic agent
Fenclofenac216Antirheumatic agent
Bexarotene aCancer therapy
Metformin 392 Anti-diabetic agent
Ipilmumab a (autoimmune hypophysitis)Cancer therapy
Pembrolizumab a (autoimmune hypophysitis)Cancer therapy
Nivolumab a (autoimmune hypophysitis)Cancer therapy

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