The Lipid Peroxidation Inhibitor Indenoindole H290/51 Protects ...

Clipboard, Search History, and several other advanced features are temporarily unavailable. Skip to main page content

The .gov means it’s official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation Search: Search Advanced Clipboard Save Email Send to

• Clipboard
• My Bibliography
• Collections
• Citation manager

Display options Display options Format Abstract PubMed PMID

Save citation to file

Format: Summary (text) PubMed PMID Abstract (text) CSV Create file Cancel

Email citation

Email address has not been verified. Go to My NCBI account settings to confirm your email and then refresh this page. To: Subject: Body: Format: Summary Summary (text) Abstract Abstract (text) MeSH and other data Send email Cancel

Add to Collections

• Create a new collection
• Add to an existing collection

Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error Please try again Add Cancel

Add to My Bibliography

• My Bibliography

Unable to load your delegates due to an error Please try again Add Cancel

Your saved search

Name of saved search: Search terms: Test search terms Would you like email updates of new search results? Saved Search Alert Radio Buttons

• Yes
• No

Email: (change) Frequency: Monthly Weekly Daily Which day? The first Sunday The first Monday The first Tuesday The first Wednesday The first Thursday The first Friday The first Saturday The first day The first weekday Which day? Sunday Monday Tuesday Wednesday Thursday Friday Saturday Report format: Summary Summary (text) Abstract Abstract (text) PubMed Send at most: 1 item 5 items 10 items 20 items 50 items 100 items 200 items Send even when there aren't any new results Optional text in email: Save Cancel

Create a file for external citation management software

Create file Cancel

Your RSS Feed

Name of RSS Feed: Number of items displayed: 5 10 15 20 50 100 Create RSS Cancel RSS Link Copy

Full text links

Elsevier Science Full text links

Actions

CiteCollectionsAdd to Collections

• Create a new collection
• Add to an existing collection

Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an errorPlease try again Add Cancel PermalinkPermalinkCopyDisplay options Display options Format AbstractPubMedPMID

Page navigation

• Title & authors
• Abstract
• Publication types
• MeSH terms
• Substances
• LinkOut - more resources

Title & authors Abstract Publication types MeSH terms Substances LinkOut - more resources Full text links CiteDisplay options Display options Format AbstractPubMedPMID

Abstract

Lipid peroxidation contributes to myocardial reperfusion injury. The indenoindole H290/51, a lipid peroxidation inhibitor with balanced lipophilicity and a considerably higher antioxidative capacity than that of vitamin E, was tested for its myocardioprotective effect against reperfusion injury. Coronary-ligated pigs were subjected to 45 min of myocardial ischemia followed by 240 min of reperfusion. Starting five minutes prior to reperfusion, H290/51 (n = 6) or vehicle (n = 6) was retrogradely infused via a coronary vein for 30 min. The total dose of H290/51 was 1 microM in 300 ml fluid (10 ml/min). In addition to the hemodynamics, left ventricular (LV) wall segment shortening (%SS) was measured by sonomicrometry. The LV area at risk and infarct size were measured by means of Evans blue and triphenyl tetrazolium chloride staining. The hemodynamics did not change significantly during the study, and no differences were found between the two groups. In the H 290/51-treated pigs, %SS of the ischemic area recovered from 1.9% at the end of ischemia to 9.1% after 120 min (p < .05) and to 16.2% at 240 min (p < .01). There was no significant recovery in the vehicle group. The LV area at risk was approximately 20% of LV. Infarct size as a percentage of LV and of the area at risk was significantly smaller in the H290/51 group (9+/-3% and 46+/-11%) than in the control group (18+/-6%; p < .05 and 83+/-5%; p < .01). H290/51 effectively protected the myocardium at risk in the setting of myocardial ischemia followed by reperfusion. This effect was reflected by diminished infarct size and improved functional recovery.

PubMed Disclaimer

Publication types

• Comparative Study Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Research Support, Non-U.S. Gov't Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search

MeSH terms

• Animals Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Antioxidants / therapeutic use* Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Drug Evaluation, Preclinical Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Female Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Free Radicals Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Hemodynamics / drug effects Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Indoles / therapeutic use* Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Lipid Peroxidation / drug effects* Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Male Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Myocardial Infarction / pathology Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Myocardial Infarction / prevention & control Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Myocardial Reperfusion Injury / prevention & control* Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Risk Factors Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Swine Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Ventricular Function, Left / drug effects Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Vitamin E / therapeutic use Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search

Substances

• Antioxidants Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Free Radicals Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• H290-51 Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Indoles Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Vitamin E Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Medical

  • MedlinePlus Health Information

Full text links [x] Elsevier Science [x] Cite Copy Download .nbib .nbib Format: AMA APA MLA NLM Send To

• Clipboard
• Email
• Save
• My Bibliography
• Collections
• Citation Manager

[x]

NCBI Literature Resources

MeSH PMC Bookshelf Disclaimer

The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.