Weak, Bidentate Chelating Group Assisted Cross-coupling Of C(sp3)

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Weak, bidentate chelating group assisted cross-coupling of C(sp3)–H bonds in aliphatic acid derivatives with aryltrifluoroborates†

Check for updates Zhihua Cai,ab Shangda Li,a Yuzhen Gao,a Lei Fua and Gang Li ORCID logo *ab Author affiliations

* Corresponding authors

a State Key Laboratory of Structural Chemistry, Center for Excellence in Molecular Synthesis, Fujian Institute of Research on the Structure of Matter, Fuzhou, Fujian 350002, China E-mail: [email protected]

b University of Chinese Academy of Science, Beijing, China

Abstract

A protocol of Pd(II)-catalyzed, weak bidentate directing group assisted β-C(sp3)–H activation/cross-coupling with organoboron reagents has been achieved, affording arylation of aliphatic acid derivatives that contain α-hydrogen atoms in moderate to good yields. The potential of this method for an asymmetric β-C(sp3)–H arylation via desymmetrization was also presented.

Graphical abstract: Weak, bidentate chelating group assisted cross-coupling of C(sp3)–H bonds in aliphatic acid derivatives with aryltrifluoroborates You have access to this article Please wait while we load your content...

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