5EK0: Human Nav1.7-VSD4-NavAb in complex with GX-936 | PDB ID: | 5EK0Download | | MMDB ID: | 135070 | | PDB Deposition Date: | 2015/11/3 | | Updated in MMDB: | 2015/12 | | Experimental Method: | x-ray diffraction | | Resolution: | 3.53 Å | | Source Organism: | synthetic construct | | Similar Structures: | VAST+ | | Download sequence data |
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Biological Unit for 5EK0: tetrameric; determined by author and by software (PISA) Molecular Components in 5EK0 | Label | Count | Molecule |
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| Proteins (4 molecules) | | ABCD | 4 | Chimera of Bacterial Ion Transport Protein and Human Sodium Channel Protein Type 9 Subunit Alpha (Gene symbol: SCN9A) | | Chemicals and Non-standard biopolymers (25 molecules) | | 1 | 21 | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE | | 2 | 4 | 3-cyano-4-[2-[2-(1-ethylazetidin-3-yl)pyrazol-3-yl]-4-(trifluoromethyl)phenoxy]-~{N}-(1,2,4-thiadiazol-5-yl)benzenesulfonamide![3-cyano-4-[2-[2-(1-ethylazetidin-3-yl)pyrazol-3-yl]-4-(trifluoromethyl)phenoxy]-~{N}-(1,2,4-thiadiazol-5-yl)benzenesulfonamide](//pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?sid=274959035) | * Click molecule labels to explore molecular sequence information. |
![3-cyano-4-[2-[2-(1-ethylazetidin-3-yl)pyrazol-3-yl]-4-(trifluoromethyl)phenoxy]-~{N}-(1,2,4-thiadiazol-5-yl)benzenesulfonamide](http://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?sid=274959035)
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303