GX-936 | PF-05196233 | CAS#1235406-09-3 | Nav1.7 Inhibitor

MedKoo Cat#: 530622 | Name: GX-936

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GX-936, also known as PF-05196233, is a Nav1.7 inhibitor. GX-936 inhibit Nav1.7 through a voltage-sensor trapping mechanism, likely by stabilizing inactivated states of the channel.

Chemical Structure

GX-936 CAS#1235406-09-3

Theoretical Analysis

MedKoo Cat#: 530622

Name: GX-936

CAS#: 1235406-09-3

Chemical Formula: C24H20F3N7O3S2

Exact Mass: 575.1021

Molecular Weight: 575.59

Elemental Analysis: C, 50.08; H, 3.50; F, 9.90; N, 17.03; O, 8.34; S, 11.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly. Bulk Inquiry

• Technical Data
• QC and Documents
• Solubility and Formulation
• References

Related CAS # No Data Synonym GX-936; GX 936; GX936; PF-05196233; PF 05196233; PF05196233. IUPAC/Chemical Name 3-Cyano-4-[2-[1-(1-ethyl-3-azetidinyl)-1H-pyrazol-5-yl]-4-(trifluoromethyl)phenoxy]-N-1,2,4-thiadiazol-5-yl-benzenesulfonamide InChi Key UCAVSLIXTXZSRD-UHFFFAOYSA-N InChi Code InChI=1S/C24H20F3N7O3S2/c1-2-33-12-17(13-33)34-20(7-8-30-34)19-10-16(24(25,26)27)3-5-22(19)37-21-6-4-18(9-15(21)11-28)39(35,36)32-23-29-14-31-38-23/h3-10,14,17H,2,12-13H2,1H3,(H,29,31,32) SMILES Code O=S(C1=CC=C(OC2=CC=C(C(F)(F)F)C=C2C3=CC=NN3C4CN(CC)C4)C(C#N)=C1)(NC5=NC=NS5)=O Appearance Solid powder Purity >98% (or refer to the Certificate of Analysis) Shipping Condition Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. Storage Condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). Solubility Soluble in DMSO Shelf Life >2 years if stored properly Drug Formulation This drug may be formulated in DMSO Stock Solution Storage 0 - 4 C for short term (days to weeks), or -20 C for long term (months). HS Tariff Code 2934.99.9001 More Info Targeting the human Nav1.7 channel involved in pain perception, we present a protein-engineering strategy that has allowed us to determine crystal structures of a novel receptor site in complex with isoform-selective antagonists. Instruction View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 575.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity % Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Ahuja S, Mukund S, Deng L, Khakh K, Chang E, Ho H, Shriver S, Young C, Lin S, Johnson JP Jr, Wu P, Li J, Coons M, Tam C, Brillantes B, Sampang H, Mortara K, Bowman KK, Clark KR, Estevez A, Xie Z, Verschoof H, Grimwood M, Dehnhardt C, Andrez JC, Focken T, Sutherlin DP, Safina BS, Starovasnik MA, Ortwine DF, Franke Y, Cohen CJ, Hackos DH, Koth CM, Payandeh J. Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist. Science. 2015 Dec 18;350(6267):aac5464. doi: 10.1126/science.aac5464. PubMed PMID: 26680203.

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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