A 77-01 (CAS 607737-87-1) - R&D Systems

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Catalog #	Availability	Size / Price	Qty
6712/25
6712/5

Request a Quote Bulk Orders Add to Cart 1 Image Description: Potent inhibitor of TGF-βRI

Chemical Name: 4-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]quinoline

Purity: ≥98%

View All Products for TGF-beta Receptor Inhibitors Product Details Citations (1) Reviews Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

A 77-01 is a potent TGF-βRI (ALK-5) inhibitor (IC50 = 34 nM). Inhibits TGF-β transcriptional activation. Inhibits TGF-β-induced proliferation of lung epithelial cells and SMAD phosphorylation. Inhibits TGF-β-induced epithelial-to-mesenchymal transition (EMT). Also inhibitor of p38 MAPK. Likely active metabolite of A 83-01 (Cat. No. 2939).

Technical Data

M.Wt: 286.33 Formula: C18H14N4 Solubility: Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl Purity: ≥98% Storage: Store at +4°C CAS No: 607737-87-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-β. Tojo et al. Cancer Sci., 2005;96:791
2. Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-β type I receptor kinase domain. Sawyer et al. J.Med.Chem., 2003;46:3953

Product Datasheets

COA view current batch SDS Reconstitution CalculatorMolarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial) ml ul = Mass (in vial) mg ug ng ÷ Desired Reconstitution Concentration mg/ml ug/ml ng/ml

Molarity Calculator

Mass picograms nanograms micrograms milligrams grams kilograms = Concentration femtomolar picomolar nanomolar micromolar millimolar molar x Volume nanoliter microliter milliliter liter x M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for A 77-01

The citations listed below are publications that use Tocris products. Selected citations for A 77-01 include:

1 Citation: Showing 1 - 1

1. Interplay among p21Waf1/Cip1, MUSASHI-1 and Krüppel-like factor 4 in activation of Bmi1-CreER reserve intestinal stem cells after gamma radiation-induced injury. Authors: Vincent W Et al. Sci Rep 2020;10:18300

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