A 77-01 | TGF-β Receptor Inhibitor - MedChemExpress

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1. TGF-beta/Smad
2. TGF-β Receptor
3. A 77-01

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A 77-01 is a potent inhibitor of transforming growth factor (TGF)-β type I receptor superfamily activin-like kinase ALK5 with an IC50 of 25 nM.

For research use only. We do not sell to patients.

A 77-01 Chemical Structure

CAS No. : 607737-87-1

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Based on 1 publication(s) in Google Scholar

A 77-01 Related Antibodies

1 Publications Citing Use of MCE A 77-01

• •Mol Med Rep. 2018 May;17(5):6301-6310. [Abstract]

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• [1]. Tojo M, et al. The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. Cancer Sci. 2005 Nov;96(11):791-800.

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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A 77-01 Related Classifications

• Cancer
• Cancer Targeted Therapy Cancer Immunotherapy Cancer Metabolism and Metastasis

• TGF-beta/Smad
• TGF-β Receptor

• Do most proteins show cross-species activity?

  Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

A 77-01607737-87-1TGF-β ReceptorTransforming growth factor beta receptorsInhibitorinhibitorinhibit

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