CH25H Gene - Ma'ayan Laboratory - Computational Systems Biology

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CH25H Gene

HGNC Family	Fatty acid hydroxylase domain containing
Name	cholesterol 25-hydroxylase
Description	This is an intronless gene that is involved in cholesterol and lipid metabolism. The encoded protein is a membrane protein and contains clusters of histidine residues essential for catalytic activity. Unlike most other sterol hydroxylases, this enzyme is a member of a small family of enzymes that utilize diiron cofactors to catalyze the hydroxylation of hydrophobic substrates. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Cholesterol 25‐hydroxylase (CH25H) is a multifunctional enzyme that oxidizes cholesterol into 25‐hydroxycholesterol (25HC), a potent oxysterol mediator that links innate immune activation with lipid metabolism and antiviral defense. In macrophages and dendritic cells, CH25H is rapidly induced in response to Toll‐like receptor stimulation via a TRIF–IFN signaling cascade, leading to robust 25HC production that dampens inflammatory responses by antagonizing sterol regulatory element–binding protein (SREBP) processing and thereby inhibiting interleukin‐1 family cytokine transcription and inflammasome activation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " Moreover, CH25H cooperates with other oxysterol‐synthesizing enzymes to generate ligand gradients (eg, 7α,25‐dihydroxycholesterol) that are essential for proper immune cell positioning in lymphoid tissues."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the context of viral infections, CH25H expression contributes directly to antiviral defense by inhibiting viral membrane fusion and replication. Its enzymatic product 25HC disrupts the formation of viral replication factories and impedes entry of enveloped viruses such as hepatitis C virus, as well as gammaherpesviruses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": " In addition, during bacterial infection with Listeria monocytogenes, CH25H is upregulated in an IFN‐β–dependent manner to modulate host cell survival and inflammatory cascades."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its immunomodulatory and antiviral properties, CH25H and 25HC play important roles in maintaining cholesterol homeostasis and vascular integrity. In endothelial cells and macrophages, activation of a KLF4–CH25H/LXR axis helps to control cholesterol biosynthesis and reduce inflammasome activity, thereby exerting a protective effect against atherosclerosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Furthermore, in metabolic tissues such as adipose tissue, CH25H expression is enriched in inflammatory cell populations and has been implicated in the progression of obesity‐associated inflammation and insulin resistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Andrea Reboldi, Eric V Dang, Jeffrey G McDonald, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1254790"}], "href": "https://doi.org/10.1126/science.1254790"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25104388"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25104388"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kiwon Park, Alan L Scott "}, {"type": "b", "children": [{"type": "t", "text": "Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Leukoc Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1189/jlb.0610318"}], "href": "https://doi.org/10.1189/jlb.0610318"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20699362"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20699362"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ulf Diczfalusy, Katarina E Olofsson, Ann-Margreth Carlsson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Lipid Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1194/jlr.M900107-JLR200"}], "href": "https://doi.org/10.1194/jlr.M900107-JLR200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19502589"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19502589"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Tangsheng Yi, Xiaoming Wang, Lisa M Kelly, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2012.06.015"}], "href": "https://doi.org/10.1016/j.immuni.2012.06.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22999953"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22999953"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": " Anggakusuma, Inés Romero-Brey, Carola Berger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.27913"}], "href": "https://doi.org/10.1002/hep.27913"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25999047"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25999047"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yu Xiang, Jing-Jie Tang, Wanyin Tao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Cholesterol 25-Hydroxylase as a Novel Host Restriction Factor and a Part of the Primary Innate Immune Responses against Hepatitis C Virus Infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.00587-15"}], "href": "https://doi.org/10.1128/JVI.00587-15"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25903345"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25903345"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Wadzanai P Mboko, Bryan C Mounce, Joseph Emmer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interferon regulatory factor 1 restricts gammaherpesvirus replication in primary immune cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.00638-14"}], "href": "https://doi.org/10.1128/JVI.00638-14"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24719409"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24719409"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Tie Zou, Oleg Garifulin, Robert Berland, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Listeria monocytogenes infection induces prosurvival metabolic signaling in macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Infect Immun (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/IAI.01195-10"}], "href": "https://doi.org/10.1128/IAI.01195-10"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21263022"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21263022"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Zhao Li, Marcy Martin, Jin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Krüppel-Like Factor 4 Regulation of Cholesterol-25-Hydroxylase and Liver X Receptor Mitigates Atherosclerosis Susceptibility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCULATIONAHA.117.027462"}], "href": "https://doi.org/10.1161/CIRCULATIONAHA.117.027462"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28794002"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28794002"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jiang Wang, Guo-Li Li, Sheng-Li Ming, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BRD4 inhibition exerts anti-viral activity through DNA damage-dependent innate immune responses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Pathog (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.ppat.1008429"}], "href": "https://doi.org/10.1371/journal.ppat.1008429"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32208449"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32208449"}]}]}]}
Synonyms	C25H
Proteins	CH25H_HUMAN
NCBI Gene ID	9023
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

CH25H has 5,007 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 104 datasets.

Click the + buttons to view associations for CH25H from the datasets below.

If available, associations are ranked by standardized value

Dataset	Summary
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CH25H gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CH25H gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of CH25H gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of CH25H gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of CH25H gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CH25H gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of CH25H gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of CH25H gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of CH25H gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
CellMarker Gene-Cell Type Associations	cell types associated with CH25H gene from the CellMarker Gene-Cell Type Associations dataset.
ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CH25H gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets	transcription factors binding the promoter of CH25H gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of CH25H gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CH25H gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing CH25H protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing CH25H protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with CH25H protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with CH25H protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of CH25H gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene Mutation Profiles	cell lines with CH25H gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
CTD Gene-Chemical Interactions	chemicals interacting with CH25H gene/protein from the curated CTD Gene-Chemical Interactions dataset.
CTD Gene-Disease Associations	diseases associated with CH25H gene/protein from the curated CTD Gene-Disease Associations dataset.
DepMap CRISPR Gene Dependency	cell lines with fitness changed by CH25H gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with CH25H gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with CH25H gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with CH25H gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with CH25H gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
DisGeNET Gene-Disease Associations	diseases associated with CH25H gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
DisGeNET Gene-Phenotype Associations	phenotypes associated with CH25H gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CH25H gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of CH25H gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets	transcription factors binding the promoter of CH25H gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing CH25H from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
GAD Gene-Disease Associations	diseases associated with CH25H gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
GAD High Level Gene-Disease Associations	diseases associated with CH25H gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of CH25H gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
GeneRIF Biological Term Annotations	biological terms co-occuring with CH25H gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing CH25H from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of CH25H gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of CH25H gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of CH25H gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CH25H gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	transcription factor perturbations changing expression of CH25H gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections	virus perturbations changing expression of CH25H gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GO Biological Process Annotations 2015	biological processes involving CH25H gene from the curated GO Biological Process Annotations 2015 dataset.
GO Biological Process Annotations 2023	biological processes involving CH25H gene from the curated GO Biological Process Annotations 2023 dataset.
GO Biological Process Annotations 2025	biological processes involving CH25H gene from the curated GO Biological Process Annotations2025 dataset.
GO Cellular Component Annotations 2015	cellular components containing CH25H protein from the curated GO Cellular Component Annotations 2015 dataset.
GO Cellular Component Annotations 2025	cellular components containing CH25H protein from the curated GO Cellular Component Annotations 2025 dataset.
GO Molecular Function Annotations 2015	molecular functions performed by CH25H gene from the curated GO Molecular Function Annotations 2015 dataset.
GO Molecular Function Annotations 2023	molecular functions performed by CH25H gene from the curated GO Molecular Function Annotations 2023 dataset.
GO Molecular Function Annotations 2025	molecular functions performed by CH25H gene from the curated GO Molecular Function Annotations 2025 dataset.
GTEx eQTL 2025	SNPs regulating expression of CH25H gene from the GTEx eQTL 2025 dataset.
GTEx Tissue Gene Expression Profiles	tissues with high or low expression of CH25H gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Gene Expression Profiles 2023	tissues with high or low expression of CH25H gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
GTEx Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CH25H gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
GTEx Tissue-Specific Aging Signatures	tissue samples with high or low expression of CH25H gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset.
GWAS Catalog SNP-Phenotype Associations 2025	phenotypes associated with CH25H gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	cell lines with high or low expression of CH25H gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset.
HMDB Metabolites of Enzymes	interacting metabolites for CH25H protein from the curated HMDB Metabolites of Enzymes dataset.
HPA Tissue Gene Expression Profiles	tissues with high or low expression of CH25H gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset.
HPA Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of CH25H gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset.
HuBMAP ASCT+B Annotations	cell types associated with CH25H gene from the HuBMAP ASCT+B dataset.
HuBMAP ASCT+B Augmented with RNA-seq Coexpression	cell types associated with CH25H gene from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset.
HuGE Navigator Gene-Phenotype Associations	phenotypes associated with CH25H gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
IMPC Knockout Mouse Phenotypes	phenotypes of mice caused by CH25H gene knockout from the IMPC Knockout Mouse Phenotypes dataset.
InterPro Predicted Protein Domain Annotations	protein domains predicted for CH25H protein from the InterPro Predicted Protein Domain Annotations dataset.
JASPAR Predicted Human Transcription Factor Targets 2025	transcription factors regulating expression of CH25H gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
JASPAR Predicted Mouse Transcription Factor Targets 2025	transcription factors regulating expression of CH25H gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset.
JASPAR Predicted Transcription Factor Targets	transcription factors regulating expression of CH25H gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	cell lines with high or low copy number of CH25H gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations	transcription factor perturbations changing expression of CH25H gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	small molecule perturbations changing expression of CH25H gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset.
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	gene perturbations changing expression of CH25H gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of CH25H gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
LOCATE Curated Protein Localization Annotations	cellular components containing CH25H protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset.
LOCATE Predicted Protein Localization Annotations	cellular components predicted to contain CH25H protein from the LOCATE Predicted Protein Localization Annotations dataset.
MGI Mouse Phenotype Associations 2023	phenotypes of transgenic mice caused by CH25H gene mutations from the MGI Mouse Phenotype Associations 2023 dataset.
MiRTarBase microRNA Targets	microRNAs targeting CH25H gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset.
MotifMap Predicted Transcription Factor Targets	transcription factors regulating expression of CH25H gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
MPO Gene-Phenotype Associations	phenotypes of transgenic mice caused by CH25H gene mutations from the MPO Gene-Phenotype Associations dataset.
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	gene perturbations changing expression of CH25H gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
MW Enzyme Metabolite Associations	interacting metabolites for CH25H protein from the MW Gene Metabolite Associations dataset.
Pathway Commons Protein-Protein Interactions	interacting proteins for CH25H from the Pathway Commons Protein-Protein Interactions dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of CH25H gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	gene perturbations changing expression of CH25H gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PFOCR Pathway Figure Associations 2023	pathways involving CH25H protein from the PFOCR Pathway Figure Associations 2023 dataset.
PFOCR Pathway Figure Associations 2024	pathways involving CH25H protein from the Wikipathways PFOCR 2024 dataset.
Reactome Pathways 2014	pathways involving CH25H protein from the Reactome Pathways dataset.
Reactome Pathways 2024	pathways involving CH25H protein from the Reactome Pathways 2024 dataset.
Roadmap Epigenomics Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at CH25H gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
RummaGEO Drug Perturbation Signatures	drug perturbations changing expression of CH25H gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures	gene perturbations changing expression of CH25H gene from the RummaGEO Gene Perturbation Signatures dataset.
Tabula Sapiens Gene-Cell Associations	cell types with high or low expression of CH25H gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset.
TargetScan Predicted Conserved microRNA Targets	microRNAs regulating expression of CH25H gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset.
TargetScan Predicted Nonconserved microRNA Targets	microRNAs regulating expression of CH25H gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors	tissue samples with high or low expression of CH25H gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores	tissues with high expression of CH25H protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores 2025	tissues with high expression of CH25H protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores	tissues with high expression of CH25H protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	tissues with high expression of CH25H protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores	tissues co-occuring with CH25H protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	tissues co-occuring with CH25H protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.
WikiPathways Pathways 2024	pathways involving CH25H protein from the WikiPathways Pathways 2024 dataset.

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Please acknowledge the Harmonizome in your publications by citing the following reference(s):

Diamant I, Clarke DJB, Evangelista JE, Lingam N, Ma'ayan A. Harmonizome 3.0: integrated knowledge about genes and proteins from diverse multi-omics resources. Nucleic Acids Res. 2024 Nov 20. pii: 53(1):D1016-D1028.

Rouillard AD, Gundersen GW, Fernandez NF, Wang Z, Monteiro CD, McDermott MG, Ma'ayan A. The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins. Database (Oxford). 2016 Jul 3;2016. pii: baw100.