HRAS K117N [plasma Membrane] - Reactome

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HRAS K117N [plasma membrane]

Stable Identifier R-HSA-9656603 Type Protein [EntityWithAccessionedSequence] Species Homo sapiens Compartment plasma membrane Locations in the PathwayBrowser Expand all Disease (Homo sapiens)

• • Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
    • Oncogenic MAPK signaling (Homo sapiens)
      • Signaling by RAS mutants (Homo sapiens)
        • RAS GTPase cycle mutants (Homo sapiens)
          • Signaling by RAS GAP mutants (Homo sapiens)
            • RAS GAP mutants aren't stimulated by GAPs (Homo sapiens)
              • RAS GAP mutants:GTP [plasma membrane] (Homo sapiens)
                • RAS GAP mutants [plasma membrane] (Homo sapiens)
                  • HRAS K117N [plasma membrane] (Homo sapiens)

External Reference Information External Reference UniProt:P01112 HRAS Gene Names HRAS, HRAS1 Chain chain:1-186, initiator methionine:1, chain:2-186, propeptide:187-189 Reference Genes BioGPS Gene:3265 HRAS COSMIC (genes):HRAS HRAS CTD Gene:3265 HRAS dbSNP Gene:3265 HRAS ENSEMBL:ENSG00000174775 HRAS HGNC:5173 HRAS KEGG:hsa:3265 HRAS Monarch:3265 HRAS NCBI Gene:3265 HRAS OMIM:190020 HRAS UCSC:P01112 HRAS Reference Transcript

• RefSeq:NM_001318054.1 HRAS
• RefSeq:NM_005343.4 HRAS
• RefSeq:NM_176795.5 HRAS
• RefSeq:XM_054368610.1 HRAS
• RefSeq:NM_001130442.3 HRAS

Other Identifiers 11733320_a_at 11744709_a_at 1590_s_at 16733952 212983_PM_at 212983_at 3265 3358091 3358092 3358093 3358094 3358095 3358096 3358097 3358098 3358099 3358100 3358101 3358102 3358103 3358104 3358105 3358106 3358107 3358108 3358109 3358111 35701_at 7945436 85278_r_at A_23_P98183 GE57461 GE792509 GO:0000139 GO:0000165 GO:0000166 GO:0002376 GO:0003924 GO:0003925 GO:0005515 GO:0005525 GO:0005634 GO:0005654 GO:0005737 GO:0005789 GO:0005794 GO:0005815 GO:0005829 GO:0005886 GO:0006355 GO:0006357 GO:0006897 GO:0006935 GO:0007165 GO:0007166 GO:0007264 GO:0007265 GO:0008284 GO:0008285 GO:0008286 GO:0009887 GO:0010628 GO:0010629 GO:0012505 GO:0014044 GO:0016020 GO:0016192 GO:0016787 GO:0019003 GO:0030335 GO:0032729 GO:0032956 GO:0036064 GO:0042088 GO:0042127 GO:0042552 GO:0042832 GO:0043410 GO:0043495 GO:0043524 GO:0045944 GO:0046330 GO:0048144 GO:0048146 GO:0048169 GO:0048471 GO:0048856 GO:0050679 GO:0050852 GO:0051402 GO:0051726 GO:0060090 GO:0060612 GO:0070374 GO:0071480 GO:0090303 GO:0090314 GO:0090398 GO:0090402 GO:0097193 GO:0098542 GO:0098696 GO:0098772 GO:0098978 GO:0160185 GO:1900029 GO:1905360 GO:2000630 HMNXSV003016066 Hs.37003.0.S1_3p_at Hs.37003.0.S1_3p_x_at ILMN_1699798 ILMN_1773751 J00277_at PH_hs_0031161 TC11001236.hg V00574_s_at Participates as a candidate of

• RAS GAP mutants [plasma membrane] (Homo sapiens)

Other forms of this molecule S-Farn-Me-2xPalmS HRAS [plasma membrane] proHRAS [cytosol] S-Farn-proHRAS [endoplasmic reticulum membrane] S-Farn-HRAS [endoplasmic reticulum membrane] S-Farn-Me HRAS [endoplasmic reticulum membrane] S-Farn-Me PalmS HRAS [Golgi membrane] HRAS [plasma membrane] S-Farn-Me HRAS [plasma membrane] HRAS G12C [plasma membrane] HRAS G12D [plasma membrane] HRAS G13S [plasma membrane] HRAS G13D [plasma membrane] HRAS G13V [plasma membrane] HRAS K117R [plasma membrane] HRAS G13C [plasma membrane] HRAS T58I [plasma membrane] HRAS G12S [plasma membrane] HRAS G12V [plasma membrane] HRAS G13R [plasma membrane] HRAS Q61K [plasma membrane] HRAS Q61L [plasma membrane] HRAS Q61R [plasma membrane] Modified Residues Name L-lysine 117 replaced with L-asparagine Coordinate 117 PsiMod L-asparagine residue [MOD:00012] A protein modification that effectively converts a source amino acid residue to an L-asparagine. L-lysine removal [MOD:01642] A protein modification that effectively removes or replaces an L-lysine. Disease

Name	Identifier	Synonyms
urinary system cancer	DOID:3996
thyroid cancer	DOID:1781	Thyroid gland neoplasm, thyroid cancer, thyroid neoplasm, neoplasm of thyroid gland, thyroid neoplasm, Thyroid neoplasm, malignant tumour of thyroid gland, malignant neoplasm of thyroid gland
breast cancer	DOID:1612	malignant tumor of the breast, mammary cancer, malignant neoplasm of breast, mammary tumor, primary breast cancer, breast cancer, Ca breast - NOS, breast tumor

Cross References RefSeq NP_001304983.1, NP_005334.1, NP_001123914.1, XP_054224585.1, NP_789765.1 Guide to Pharmacology - Targets 2822 OpenTargets ENSG00000174775 ENSEMBL ENSP00000482366, ENST00000634098, ENST00000397594, ENST00000397596, ENSP00000407586, ENSP00000480686, ENSP00000434023, ENST00000417302, ENST00000615062, ENSP00000388246, ENSP00000488296, ENST00000311189, ENSP00000309845, ENST00000610977, ENSG00000174775, ENSP00000488757, ENSP00000480317, ENSP00000380722, ENSP00000380723, ENST00000451590, ENST00000616241, ENST00000493230, ENST00000631967, ENST00000631404, ENSP00000488225, ENSG00000276536 Mondo 0006295 ZINC - Substances RASH_HUMAN ZINC target P01112 PRO P01112 GlyGen P01112 PDB 6BVM, 2RGD, 1HE8, 4EFN, 2EVW, 5WFO, 1JAI, 5ZC6, 4DLT, 4XVR, 5WPL, 6D59, 6D5W, 1CRP, 521P, 3RS3, 5WDP, 7DPH, 2RGG, 6V9F, 7OG9, 4L9S, 1NVU, 4URZ, 2X1V, 4URX, 8ELU, 5VBZ, 3L8Z, 3LBH, 3RRY, 6Q21, 6BVL, 2RGC, 8BE6, 4NYM, 1RVD, 2CLD, 6ZJ0, 121P, 2LCF, 4DST, 4DLU, 6E6P, 1K8R, 5B2Z, 3KKM, 6V9L, 3LO5, 5VBE, 8TBG, 7L0F, 6D5V, 3OIW, 8ELV, 4NYJ, 8ELX, 8OSM, 1BKD, 1Q21, 1CLU, 721P, 1JAH, 5WFQ, 3KUD, 3LBN, 2CLC, 821P, 1LFD, 6D5H, 4DSU, 3RSO, 7TAM, 3K9L, 1IAQ, 1ZW6, 4DLV, 7OGE, 4US0, 6D5E, 2CL0, 6V9N, 3KKN, 5B30, 2Q21, 221P, 8ELS, 6NTC, 7JIH, 2RGB, 5WFP, 6CUP, 3RRZ, 2LWI, 7JHP, 1CTQ, 6D5G, 1XD2, 6D56, 8BE9, 1P2V, 4XVQ, 3K9N, 2C5L, 2N42, 2UZI, 4US1, 1PLL, 4RSG, 5E95, 4DLW, 6E6C, 6V9M, 8ELT, 8BEA, 1NVX, 4US2, 8BWG, 1GNR, 7JII, 2RGA, 5WFR, 8WWC, 2VH5, 6MQT, 6D5J, 4K81, 6D55, 1P2U, 621P, 1LF5, 8BE7, 8OSN, 7OGF, 2CL7, 1PLK, 8TLR, 7L0G, 1WQ1, 6AXG, 2CE2, 4DLX, 4DLR, 3DDC, 6NTD, 1GNQ, 8ELR, 8ELY, 1LF0, 7VV9, 3RS4, 3LBI, 5X9S, 4G3X, 7OGA, 6V94, 6D5L, 6CUO, 1P2T, 8BE8, 4G0N, 4DLS, 4L9W, 2CL6, 3RS0, 1ZVQ, 4DLY, 6AMB, 1NVW, 4URU, 6ZL3, 8ELZ, 7JIF, 1GNP, 3OIU, 7VV8, 3RSL, 6CUR, 3K8Y, 3RS5, 6BVK, 8FG3, 421P, 1XCM, 1P2S, 1CRR, 1AGP, 2N46, 8BOS, 4DLZ, 8OSO, 3I3S, 6V9O, 7OGC, 2QUZ, 5WDO, 1PLJ, 8CNJ, 3TGP, 4URV, 1AA9, 1XJ0, 6DZH, 4URY, 3L8Y, 8EM0, 4EFM, 1IOZ, 8FG4, 2RGE, 6BVJ, 3RS7, 8CNN, 6V9J, 7VVG, 1CRQ, 4EFL, 4Q21, 5P21, 7DPJ, 5WDQ, 1QRA, 7OGD, 6D5M, 7OGB, 3RS2, 1NVV, 3OIV, 4URW, 4NYI, 7JIG, 8ELK, 8ELW, 6BVI ZINC - Investigational RASH_HUMAN COSMIC COSV54236714, COSV54237107 GeneCards HRAS HPA ENSG00000174775-HRAS Pharos - Targets P01112 Orphanet HRAS ZINC - Predictions - Purchasable RASH_HUMAN HMDB Protein HMDBP01958 Interactors (35)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.978	30
UniProt:Q07889 SOS1	3	SOS1 [cytosol] (R-HSA-64847) SOS1 [plasma membrane] (R-HSA-983559) p-4S-SOS1 [cytosol] (R-HSA-109821)	0.938	11
UniProt:P15056 BRAF	20	p-S,T-BRAF [cytosol] (R-HSA-169856) BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620)	0.931	9
UniProt:Q9NZL6 RGL1	1	RGL1 [cytosol] (R-HSA-561160)	0.744	4
UniProt:Q12967 RALGDS	1	RALGDS [cytosol] (R-HSA-171001)	0.683	3
UniProt:Q8WUX9 CHMP7	2	CHMP7 [cytosol] (R-HSA-917703) CHMP7 [endosome membrane] (R-HSA-9631168)	0.659	4
UniProt:P21359 NF1	20	NF1 R816* [cytosol] (R-HSA-6802424) NF1 F1464L [cytosol] (R-HSA-6802410) NF1 K1444E [cytosol] (R-HSA-6802414) NF1 L1187I [cytosol] (R-HSA-6802417) NF1 R1276P [cytosol] (R-HSA-6802420) NF1 R1412S [cytosol] (R-HSA-6802421) NF1 R2517* [cytosol] (R-HSA-9647532) NF1 Q616Gfs*4 [cytosol] (R-HSA-9647468) NF1 R2450* [cytosol] (R-HSA-9647535) NF1 R2637* [cytosol] (R-HSA-9647529) NF1 R2637Q [cytosol] (R-HSA-9647525) NF1 R304* [cytosol] (R-HSA-9647522) NF1 R1276* [cytosol] (R-HSA-9647550) NF1 C845Vfs*33 [cytosol] (R-HSA-9647486) NF1(2-2839) [cytosol] (R-HSA-947770) ub-NF1(2-2839) [cytosol] (R-HSA-5658418) NF1 R69Nfs*7 [cytosol] (R-HSA-9647505) NF1 R440* [cytosol] (R-HSA-9647511) NF1 R440Q [cytosol] (R-HSA-9647508) NF1 G849E fs*29 [cytosol] (R-HSA-9656596)	0.604	3
UniProt:P42337 Pik3ca	1	Pik3ca [cytosol] (R-MMU-9027214)	0.589	3
UniProt:P52306 RAP1GDS1	1	RAP1GDS1 [mitochondrial outer membrane] (R-HSA-9693756)	0.589	2
UniProt:Q9Y5Z9 UBIAD1	1	UBIAD1 [endoplasmic reticulum membrane] (R-HSA-2980965)	0.581	9
UniProt:P11233 RALA	2	RALA [cytosol] (R-HSA-170988) GGC-RALA [cytoplasmic vesicle membrane] (R-HSA-1458479)	0.571	2
UniProt:P12931 SRC	6	MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG-SRC [plasma membrane] (R-HSA-8876922) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276)	0.571	2
UniProt:Q9EQZ6	1	Rapgef4 [plasma membrane] (R-MMU-3008666)	0.556	3
UniProt:Q96EZ8 MCRS1	1	MCRS1 [nucleoplasm] (R-HSA-3321849)	0.556	3
UniProt:O14641 DVL2	5	pp-DVL2 [cytosol] (R-HSA-3772398) p-DVL2 [cytosol] (R-HSA-201706) DVL2 [cytosol] (R-HSA-201694) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444) ub-DVL2 [cytosol] (R-HSA-4652689)	0.556	3
UniProt:O95674 CDS2	1	CDS2 [mitochondrial inner membrane] (R-HSA-1498755)	0.556	3
UniProt:O15534 PER1	4	PER1 [cytosol] (R-HSA-400373) p-S-PER1 [nucleoplasm] (R-HSA-3325590) p-S-PER1 [cytosol] (R-HSA-400310) K48polyUb-K,p-S-PER1 [cytosol] (R-HSA-517831)	0.556	3
UniProt:A0AVK6 E2F8	1	E2F8 [nucleoplasm] (R-HSA-8952990)	0.556	3
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.556	3
UniProt:P10809 HSPD1	6	HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1 [mitochondrial matrix] (R-HSA-1299448) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1(1-573) [cytosol] (R-HSA-1267989)	0.556	3
UniProt:P22415 USF1	2	USF1 [nucleoplasm] (R-HSA-9023562) pT153 USF1 [nucleoplasm] (R-HSA-9855887)	0.556	3
UniProt:Q8N5V2 NGEF	2	p-Y179-NGEF [cytosol] (R-HSA-3928441) NGEF [cytosol] (R-HSA-3006800)	0.556	3
UniProt:Q13352 ITGB3BP	2	ITGB3BP [cytosol] (R-HSA-3006405) ITGB3BP [nucleoplasm] (R-HSA-606325)	0.556	3
UniProt:Q9BXU0 TEX12	1	TEX12 [nucleoplasm] (R-HSA-912441)	0.556	3
UniProt:Q99558 MAP3K14	5	Active NIK [cytosol] (R-HSA-5607646) MAP3K14 [cytosol] (R-HSA-168189) p-MAP3K14 [cytosol] (R-HSA-168187) K48polyUb-NIK [cytosol] (R-HSA-5668525) p-T559-MAP3K14 [cytosol] (R-HSA-5668531)	0.556	3
UniProt:O75528 TADA3	1	TADA3 [nucleoplasm] (R-HSA-3322966)	0.556	3
UniProt:Q00994 BEX3	1	NGFRAP1 [cytosol] (R-HSA-194333)	0.556	3
UniProt:Q12824 SMARCB1	1	SMARCB1 [nucleoplasm] (R-HSA-389261)	0.556	3
UniProt:P24941 CDK2	5	p-T160-CDK2 [nucleoplasm] (R-HSA-187967) CDK2 [nucleoplasm] (R-HSA-68365) CDK2 [cytosol] (R-HSA-157440) p-CDK2 [nucleoplasm] (R-HSA-68370) p-Y15-CDK2 [nucleoplasm] (R-HSA-187905)	0.556	3
UniProt:P53611 RABGGTB	2	RABGGTB [plasma membrane] (R-HSA-6801098) RABGGTB [cytosol] (R-HSA-8870419)	0.527	3
UniProt:Q7Z569 BRAP	2	ub-BRAP [cytosol] (R-HSA-5674001) BRAP [cytosol] (R-HSA-5672938)	0.524	3
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.519	5
UniProt:Q03135 CAV1	5	CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [endocytic vesicle membrane] (R-HSA-535009) CAV1 [early endosome membrane] (R-HSA-5368451)	0.508	2
UniProt:Q16850 CYP51A1	1	CYP51A1 [endoplasmic reticulum membrane] (R-HSA-194721)	0.483	2
UniProt:P42684 ABL2	1	ABL2 [cytosol] (R-HSA-375998)	0.462	2

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