KRAS K117N [plasma Membrane] - Reactome

Trang chủ » K117n » KRAS K117N [plasma Membrane] - Reactome

Có thể bạn quan tâm

Reactome Pathway Database Toggle navigation
  • About
    • What is Reactome ?
    • News
    • Team
    • Scientific Advisory Board
    • Funding
    • Editorial Calendar
    • Release Calendar
    • Statistics
    • Our Logo
    • License Agreement
    • Privacy Notice
    • Disclaimer
    • Digital Preservation
    • Contact us
  • Content
    • Table of Contents
    • DOIs
    • Data Schema
    • Reactome Research Spotlight
    • ORCID Integration Project
    • COVID-19 Disease Pathways
  • Docs
    • Userguide
      • Pathway Browser
      • How do I search ?
      • Details Panel
      • Analysis Tools
        • Analysis Data
        • Analysis Gene Expression
        • Species Comparison
        • Tissue Distribution
      • Diseases
      • Cytomics
      • Review Status of Reactome Events
      • ReactomeFIViz
    • Developer's Zone
      • Graph Database
      • Analysis Service
      • Content Service
      • Pathways Overview
      • Pathway Diagrams
    • Icon Info
      • EHLD Specs & Guidelines
      • Icon Library Guidelines
    • Data Model
    • Curator Guide
    • Release Documentation
    • Computationally inferred events
    • FAQ
    • Linking to Us
    • Citing us
  • Tools
    • Pathway Browser
    • Analyse gene list
    • Analyse gene expression
    • Species Comparison
    • Tissue Distribution
    • Analysis Service
    • Content Service
    • ReactomeFIViz
    • Advanced Data Search
    • Site Search
  • Community
    • Contribute Pathway Knowledge
    • Icon Library
    • Outreach
    • Events
    • Publications
    • Partners
    • Contributors
    • Resources Guide
  • Download
Reactome Pathway Database
  • About
    • What is Reactome ?
    • News
    • Team
    • Scientific Advisory Board
    • Funding
    • Editorial Calendar
    • Release Calendar
    • Statistics
    • Our Logo
    • License Agreement
    • Privacy Notice
    • Disclaimer
    • Digital Preservation
    • Contact us
  • Content
    • Table of Contents
    • DOIs
    • Data Schema
    • Reactome Research Spotlight
    • ORCID Integration Project
    • COVID-19 Disease Pathways
  • Docs
    • Userguide
      • Pathway Browser
      • How do I search ?
      • Details Panel
      • Analysis Tools
        • Analysis Data
        • Analysis Gene Expression
        • Species Comparison
        • Tissue Distribution
      • Diseases
      • Cytomics
      • Review Status of Reactome Events
      • ReactomeFIViz
    • Developer's Zone
      • Graph Database
      • Analysis Service
      • Content Service
      • Pathways Overview
      • Pathway Diagrams
    • Icon Info
      • EHLD Specs & Guidelines
      • Icon Library Guidelines
    • Data Model
    • Curator Guide
    • Release Documentation
    • Computationally inferred events
    • FAQ
    • Linking to Us
    • Citing us
  • Tools
    • Pathway Browser
    • Analyse gene list
    • Analyse gene expression
    • Species Comparison
    • Tissue Distribution
    • Analysis Service
    • Content Service
    • ReactomeFIViz
    • Advanced Data Search
    • Site Search
  • Community
    • Contribute Pathway Knowledge
    • Icon Library
    • Outreach
    • Events
    • Publications
    • Partners
    • Contributors
    • Resources Guide
  • Download
Search ... Go!

KRAS K117N [plasma membrane]

Stable Identifier R-HSA-9653095 Type Protein [EntityWithAccessionedSequence] Species Homo sapiens Compartment plasma membrane Locations in the PathwayBrowser Expand all Disease (Homo sapiens)
    • Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
      • Oncogenic MAPK signaling (Homo sapiens)
        • Signaling by RAS mutants (Homo sapiens)
          • RAS GTPase cycle mutants (Homo sapiens)
            • Signaling by RAS GAP mutants (Homo sapiens)
              • RAS GAP mutants aren't stimulated by GAPs (Homo sapiens)
                • RAS GAP mutants:GTP [plasma membrane] (Homo sapiens)
                  • RAS GAP mutants [plasma membrane] (Homo sapiens)
                    • KRAS K117N [plasma membrane] (Homo sapiens)
Literature References
PubMed ID Title Journal Year
20147967 Activating K-Ras mutations outwith 'hotspot' codons in sporadic colorectal tumours - implications for personalised cancer medicine

Smith, G, Bounds, R, Wolf, H, Steele, RJ, Carey, FA, Wolf, CR

Br. J. Cancer 2010
External Reference Information External Reference UniProt:P01116 KRAS Gene Names KRAS, KRAS2, RASK2 Chain chain:1-186, initiator methionine:1, chain:2-186, propeptide:187-189 Reference Genes BioGPS Gene:3845 KRAS COSMIC (genes):KRAS KRAS CTD Gene:3845 KRAS dbSNP Gene:3845 KRAS ENSEMBL:ENSG00000133703 KRAS HGNC:6407 KRAS KEGG:hsa:3845 KRAS Monarch:3845 KRAS NCBI Gene:3845 KRAS OMIM:190070 KRAS UCSC:P01116 KRAS Reference Transcript
  • RefSeq:NM_001369786.1 KRAS
  • RefSeq:NM_033360.4 KRAS
  • RefSeq:XM_011520653.2 KRAS
  • RefSeq:NM_001369787.1 KRAS
  • RefSeq:NM_004985.4 KRAS
  • RefSeq:XM_006719069.3 KRAS
Participates as a member of
  • RAS GAP mutants [plasma membrane] (Homo sapiens)
Other forms of this molecule S-Farn-Me-PalmS KRAS [plasma membrane] p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane] KRAS A146T [plasma membrane] KRAS K147E [plasma membrane] KRAS K147T [plasma membrane] KRAS V14G [plasma membrane] KRAS K147N [plasma membrane] KRAS A146V [plasma membrane] KRAS A146S [plasma membrane] KRAS A146P [plasma membrane] KRAS P34R [plasma membrane] KRAS P34L [plasma membrane] KRAS G12A [plasma membrane] KRAS G12R [plasma membrane] KRAS G13V [plasma membrane] KRAS G13S [plasma membrane] KRAS G13C [plasma membrane] KRAS G13R [plasma membrane] KRAS G13A [plasma membrane] KRAS K5N [plasma membrane] KRAS G12S [plasma membrane] KRAS Q61L [plasma membrane] KRAS Q61K [plasma membrane] KRAS Q61R [plasma membrane] KRAS F156L [plasma membrane] KRAS G12C [plasma membrane] proKRAS [cytosol] S-Farn-proKRAS [endoplasmic reticulum membrane] S-Farn-KRAS [endoplasmic reticulum membrane] S-Farn-Me KRAS [endoplasmic reticulum membrane] KRAS [plasma membrane] KRAS A59T [plasma membrane] KRAS E63K [plasma membrane] KRAS G60D [plasma membrane] KRAS G60V [plasma membrane] KRAS Q22K [plasma membrane] KRAS D33E [plasma membrane] KRAS G60R [plasma membrane] KRAS T58I [plasma membrane] KRAS G13D [plasma membrane] KRAS D153V [plasma membrane] KRAS G12V [plasma membrane] KRAS V14I [plasma membrane] KRAS Q61H [plasma membrane] KRAS Q22R [plasma membrane] KRAS Q22E [plasma membrane] KRAS G12D [plasma membrane] KRAS L19F [plasma membrane] Modified Residues Name L-lysine 117 replaced with L-asparagine Coordinate 117 PsiMod L-asparagine residue [MOD:00012] A protein modification that effectively converts a source amino acid residue to an L-asparagine. L-lysine removal [MOD:01642] A protein modification that effectively removes or replaces an L-lysine. Disease
Name Identifier Synonyms
colorectal cancer DOID:9256
hematologic cancer DOID:2531 hematopoietic cancer, hematopoietic tumors, Hematologic neoplasm (disorder), Hematologic malignancy, hematopoietic neoplasm (morphologic abnormality), Hematologic malignancy (disorder), Hematological tumors, blood cancer, hematopoietic and lymphoid system tumor, malignant hematopoietic neoplasm (morphologic abnormality)
Cross References RefSeq NP_203524.1, NP_004976.2, XP_011518955.1, NP_001356716.1, NP_001356715.1, XP_006719132.1 Guide to Pharmacology - Targets 2824 OpenTargets ENSG00000133703 ENSEMBL ENSP00000509238, ENST00000311936, ENSP00000256078, ENST00000685328, ENST00000688940, ENSG00000133703, ENST00000256078, ENSP00000308495, ENSP00000508921 Mondo 0002334 ZINC - Substances RASK_HUMAN ZINC target P01116 PRO P01116 PDB 6GJ6, 8STM, 6F76, 8R7W, 8T75, 6V6F, 4TQ9, 8EDY, 8B00, 1N4R, 6TAN, 5VBM, 4M21, 6GOG, 6USX, 4PZZ, 8TBK, 4M1T, 6P8Y, 6QUX, 8QUG, 8G9Q, 7EYX, 7T47, 6YR8, 2MSD, 8X6R, 5V71, 6ASE, 7ROV, 9BI1, 5WHE, 6FA1, 7KYZ, 8TXK, 7MDP, 7EWA, 7STF, 8EZG, 6T5B, 8FMI, 7RP3, 8WTE, 6W4F, 8AZV, 8B6I, 4DSN, 6O46, 6OIM, 8AFD, 8STN, 8R7X, 8AQ7, 8PI0, 7RT3, 6GQY, 5VQ8, 8TBH, 1N4Q, 4TQA, 6TAM, 6PTW, 9BG1, 5VP7, 8VR9, 8DVG, 8G4F, 7T1F, 6UT0, 5OCT, 6MBU, 5VQ6, 5O2T, 7OK4, 7RSE, 8DGT, 5KYK, 6XGV, 6B0Y, 6PQ3, 6XHA, 6VJJ, 8K4V, 6WS2, 8TY2, 8AZY, 7LC1, 7EWB, 6EPP, 8FMJ, 5TB5, 7RP4, 7O70, 8EIE, 8BE3, 6O4Z, 6GJ5, 7Q9U, 8UN5, 7KMR, 4OBE, 6OB2, 8ONV, 5VQ1, 7A1X, 6GQX, 7ACH, 8T74, 6GOF, 4LYF, 4LRW, 8TBF, 4M22, 8JGD, 6P8X, 7RSC, 6ARK, 8DGS, 9KPM, 8PIY, 8QU8, 7RT5, 4EPW, 2MSC, 7R0Q, 8EBZ, 6XGU, 8WUL, 6MS9, 9BHQ, 8BE4, 8EPW, 8TXH, 6BOF, 6CCX, 8T73, 8AZZ, 8CX5, 8TXG, 6W4E, 5WPM, 4DSO, 6FA4, 7TLK, 6USZ, 6O36, 5V9L, 4Q03, 6GJ8, 1KZO, 8AQ5, 9E5F, 4LDJ, 7ACA, 6T5V, 7A1W, 5VQ0, 8UN4, 7C40, 4L8G, 4M1Y, 8QVU, 8EER, 8TBL, 6QUU, 7RT4, 5VPZ, 4M1W, 6ASA, 6JTP, 6V65, 8DNJ, 6JTO, 6XHB, 7RPZ, 7VVB, 6P8Z, 9BI2, 8K4T, 8ECR, 6EPL, 8RRO, 8UN3, 1N4P, 8YJ2, 8AZR, 6EPO, 7F0W, 7A47, 6FA3, 6MQG, 5WHD, 6O51, 9BFY, 8AFB, 6PTS, 8JHL, 5V6V, 7OO7, 7KFZ, 7LZ5, 5V9O, 6T5U, 5OCO, 8VGQ, 8TBN, 9BFW, 4LYH, 6E6G, 8QW6, 8TBM, 6QUW, 7A1Y, 5O2S, 5VQ2, 4EPX, 5OCG, 5VPI, 6ZL5, 8VJZ, 4EPR, 6JTN, 7EW9, 9BHO, 4LV6, 8I5C, 6VC8, 6O4Y, 5US4, 4Q01, 8DNK, 8TXE, 6WS4, 8FMK, 8YIV, 9AX6, 4QL3, 6OB3, 7ACQ, 6ZLI, 5UQW, 6V5L, 6GJ7, 7RP2, 6E6F, 5WLB, 4LYJ, 7YV1, 8T71, 8I5E, 8TVK, 6GOE, 8T4V, 8RNI, 8QW7, 5W22, 5VPY, 8G4H, 7RT1, 7C41, 4LPK, 9KPN, 1D8D, 8B69, 4EPY, 6N2K, 8CPR, 6YXW, 6M9W, 5WHA, 8VRA, 6B0V, 5UFE, 8JJS, 7TLE, 8I5D, 6FA2, 7YCE, 7NY8, 8TY9, 9E9I, 8UDR, 8VRB, 8AZX, 8V3A, 1KZP, 6EPN, 5F2E, 7W5R, 6WGN, 4NMM, 8T72, 8AFC, 8F0M, 9E5D, 7ACF, 6H47, 5YY1, 7U8H, 6GQT, 8G9P, 4M1S, 5XCO, 8TBJ, 7SCW, 6MBT, 7R0M, 3GFT, 7LGI, 8S8C, 4EPT, 7TLG, 6PGP, 5TAR, 6CCH, 5MLA, 2MSE, 6MQN, 4Q02, 8TXJ, 6MNX, 8G42, 7LC2, 7YUZ, 8BE5, 5UK9, 4PZY, 7MQU, 9C15, 9BFZ, 1N4S, 5UFQ, 6MTA, 5YXZ, 6BP1, 5V9U, 1D8E, 6H46, 6P0Z, 6P8W, 6QUV, 6GOD, 6CC9, 7SCX, 7RT2, 8B78, 4M1O, 6GQW, 6GOM, 7OK3, 6MBQ, 8K50, 9E9H, 4EPV, 6N2J, 7R0N, 5MLB, 6PGO, 4WA7, 9BHP, 8TY8, 4LUC, 8BLR, 6O53, 5WHB, 6CU6, 8DNI, 5USJ, 8V39, 5V6S, 8G47, 7YCC, 6EPM COSMIC COSV55504752, COSV55545304, COSM30612 GeneCards KRAS HPA ENSG00000133703-KRAS Pharos - Targets P01116 Orphanet KRAS HMDB Protein HMDBP08526 Interactors (13)
Accession #Entities Entities Confidence Score Evidence (IntAct)
UniProt:P04049 RAF1 20
  • p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465)
  • p-S338-RAF1 [cytosol] (R-HSA-5624469)
  • p-S621-RAF1 S259F [cytosol] (R-HSA-9656124)
  • p-S621-RAF1 S257L [cytosol] (R-HSA-9656121)
  • p-S621-RAF1 P261L [cytosol] (R-HSA-9656106)
  • p-S621-RAF1 N262K [cytosol] (R-HSA-9656101)
  • p-S621-RAF1 P261A [cytosol] (R-HSA-9656103)
  • p-S621-RAF1 P261S [cytosol] (R-HSA-9656113)
  • p-S621-RAF1 S259T [cytosol] (R-HSA-9656130)
  • p-S621-RAF1 P261T [cytosol] (R-HSA-9656115)
  • p-S621-RAF1 P261R [cytosol] (R-HSA-9656110)
  • p-S621-RAF1 S259P [cytosol] (R-HSA-9656127)
  • p-S621-RAF1 T260I [cytosol] (R-HSA-9656136)
  • p-S621-RAF1 T260R [cytosol] (R-HSA-9656139)
  • p-S621-RAF1 V263A [cytosol] (R-HSA-9656148)
  • p-S621-RAF1 R256S [cytosol] (R-HSA-9656119)
  • p-S621-RAF1 T491I [cytosol] (R-HSA-9656143)
  • p-S621-RAF1 D486N [cytosol] (R-HSA-9656088)
  • p-S621-RAF1 S427G [cytosol] (R-HSA-9656134)
  • p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)
0.695 6
UniProt:P15056 BRAF 20
  • p-S,T-BRAF [cytosol] (R-HSA-169856)
  • BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402)
  • p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536)
  • BRAF E501G [cytosol] (R-HSA-9651132)
  • BRAF D594N [cytosol] (R-HSA-6802299)
  • BRAF D638E [cytosol] (R-HSA-9651125)
  • BRAF G596R [cytosol] (R-HSA-6802385)
  • BRAF D594V [cytosol] (R-HSA-6802305)
  • BRAF G596V [cytosol] (R-HSA-9651138)
  • BRAF G466E [cytosol] (R-HSA-6802374)
  • BRAF D594G [cytosol] (R-HSA-6802295)
  • BRAF L505H [cytosol] (R-HSA-9648845)
  • BRAF F595L [cytosol] (R-HSA-6802316)
  • BRAF L597V [cytosol] (R-HSA-6802397)
  • BRAF G464E [cytosol] (R-HSA-6802369)
  • BRAF N581D [cytosol] (R-HSA-9651152)
  • BRAF E586K [cytosol] (R-HSA-6802308)
  • BRAF V600K [cytosol] (R-HSA-6802502)
  • BRAF A246P [cytosol] (R-HSA-9651123)
  • BRAF G469V [cytosol] (R-HSA-9648620)
0.68 5
UniProt:Q99755 PIP5K1A 1
  • PIP5K1A [cytosol] (R-HSA-1806260)
0.661 9
UniProt:Q96II5 Q96II5 0.556 3
UniProt:P50749 RASF2 0.544 2
UniProt:O75915 ARL6IP5 1
  • ARL6IP5 [cytosol] (R-HSA-2980942)
0.519 2
UniProt:P61586 RHOA 6
  • RHOA [plasma membrane] (R-HSA-194510)
  • RHOA [cell junction] (R-HSA-2134503)
  • RHOA [cytosol] (R-HSA-194866)
  • RHOA [ficolin-1-rich granule membrane] (R-HSA-6804971)
  • RHOA [secretory granule membrane] (R-HSA-6804980)
  • RHOA [endoplasmic reticulum membrane] (R-HSA-5672082)
0.519 2
UniProt:P10398 ARAF 4
  • p-S299,S302,T452,T455,S582 ARAF [cytosol] (R-HSA-5672646)
  • p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (R-HSA-5672648)
  • p-S582 ARAF [cytosol] (R-HSA-5672681)
  • p-S214,S582 ARAF [cytosol] (R-HSA-5672639)
0.483 2
UniProt:P28288 ABCD3 2
  • ABCD3 [cytosol] (R-HSA-1456459)
  • ABCD3 [peroxisomal membrane] (R-HSA-1456468)
0.483 2
UniProt:P01111 NRAS 20
  • S-Farn-Me PalmS NRAS [plasma membrane] (R-HSA-9647910)
  • proNRAS [cytosol] (R-HSA-9647758)
  • S-Farn-proNRAS [endoplasmic reticulum membrane] (R-HSA-9647928)
  • S-Farn NRAS [endoplasmic reticulum membrane] (R-HSA-9647782)
  • S-Farn-Me NRAS [endoplasmic reticulum membrane] (R-HSA-9647891)
  • S-Farn-Me PalmS NRAS [Golgi membrane] (R-HSA-9647906)
  • NRAS [plasma membrane] (R-HSA-62725)
  • S-Farn-Me NRAS [plasma membrane] (R-HSA-9647893)
  • NRAS Q60E [plasma membrane] (R-HSA-9656589)
  • NRAS G12D [plasma membrane] (R-HSA-6802339)
  • NRAS G12S [plasma membrane] (R-HSA-6802347)
  • NRAS G13D [plasma membrane] (R-HSA-6802363)
  • NRAS Q61K [plasma membrane] (R-HSA-6802446)
  • NRAS Q61L [plasma membrane] (R-HSA-6802455)
  • NRAS Q61R [plasma membrane] (R-HSA-6802461)
  • NRAS Q61P [plasma membrane] (R-HSA-9649680)
  • NRAS G12A [plasma membrane] (R-HSA-9649657)
  • NRAS G12R [plasma membrane] (R-HSA-9649662)
  • NRAS G12C [plasma membrane] (R-HSA-9649660)
  • NRAS G12V [plasma membrane] (R-HSA-9649666)
0.483 2
UniProt:Q7KZI7 MARK2 0.483 2
UniProt:Q9UQB8 BAIAP2 1
  • BAIAP2 [cytosol] (R-HSA-442574)
0.483 2
ChEBI:16618 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,4,5-TRISPHOSPHATE 0.462 2
  • About
    • What is Reactome ?
    • News
    • Team
    • Scientific Advisory Board
    • Funding
    • Editorial Calendar
    • Release Calendar
    • Statistics
    • Our Logo
    • License Agreement
    • Privacy Notice
    • Disclaimer
    • Digital Preservation
    • Contact us
  • Content
    • Table of Contents
    • DOIs
    • Data Schema
    • Reactome Research Spotlight
    • ORCID Integration Project
    • COVID-19 Disease Pathways
  • Docs
    • Userguide
    • Developer's Zone
    • Icon Info
    • Data Model
    • Curator Guide
    • Release Documentation
    • Computationally inferred events
    • FAQ
    • Linking to Us
    • Citing us
  • Tools
    • Pathway Browser
    • Analyse gene list
    • Analyse gene expression
    • Species Comparison
    • Tissue Distribution
    • Analysis Service
    • Content Service
    • ReactomeFIViz
    • Advanced Data Search
    • Site Search
  • Community
    • Contribute Pathway Knowledge
    • Icon Library
    • Outreach
    • Events
    • Publications
    • Partners
    • Contributors
    • Resources Guide
  • Download

© 2025 Reactome

This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice. I agree, dismiss this banner Cite Us! Cite Us!

Cite Us!

Warning! Unable to extract citation. Please try again later.
Download As:
BibTeX RIS Text Download Close

Từ khóa » K117n