CH25H Protein Expression Summary

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• TISSUE
• BRAIN
• SINGLE CELL
• SUBCELLULAR
• CANCER
• BLOOD
• CELL LINE
• STRUCTURE
• INTERACTION

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Search Fields » Search result AND NOT Field AllGene nameProtein classUniprot keywordChromosomeExternal idTissue expression (IHC)Multiplex tissue (IHC)Patient ID (IHC)Secretome annotationTissue category (RNA)Tissue Tau score (RNA)Tissue expression cluster (RNA)Reliability score tissue (IHC)Brain region category (RNA)Brain Tau score (RNA)Mouse brain category (RNA)Mouse brain Tau score (RNA)Pig brain category (RNA)Pig brain Tau score (RNA)Brain expression cluster (RNA)Reliability score mouse brainCell type enrichment (RNA)Cell type category (scRNA)Cell type Tau score (RNA)Cell type group category (scRNA)Cell type group Tau score (RNA)Brain region cell type (scRNA)Brain region Tau score (scRNA)Immune cell category (RNA)Immune cell Tau score (RNA)Immune cell lineage category (RNA)Immune cell lineage Tau score (RNA)Immune cell expression cluster (RNA)Single cell type expression cluster (RNA)Subcellular location (ICC)Subcellular location - cell line (ICC)Predicted locationSubcellular Cell Cycle Peak PhaseReliability score cells (ICC)Prognostic cancerCancer category (RNA)Cell line category (RNA)Celline Tau score (RNA)Cell line expression cluster (RNA)Protein sequence variantsProtein interactionProtein interaction countMetabolic pathwayStructure ipTMEvidence summaryUniProt evidenceNeXtProt evidenceHPA evidenceProtein array (PA)Western blot (WB)Immunohistochemistry (IHC)Immunocytochemistry (ICC)With antibodiesHas dataSort by Term Gene name Class Blood group antigen proteinsCancer-related genesCandidate cardiovascular disease genesCD markersCitric acid cycle related proteinsDisease related genesEnzymesEssential proteinsFDA approved drug targetsG-protein coupled receptorsHuman disease related genesImmunoglobulin genesMapped to neXtProtMapped to UniProt SWISS-PROTMetabolic proteinsNuclear receptorsPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteinsProtein evidence (Ezkurdia et al 2014)Protein evidence (Kim et al 2014)RAS pathway related proteinsRibosomal proteinsRNA polymerase related proteinsT-cell receptor genesTranscription factorsTransportersVoltage-gated ion channels Subclass Category Biological processMolecular functionDisease Keyword Chromosome 12345678910111213141516171819202122MTUnmappedXY External id Tissue AnyAdipose tissueAdrenal glandAppendixBone marrowBreastBronchusBrown adipose tissueCartilageCaudateCerebellumCerebral cortexCervixChoroid plexusColonDorsal rapheDuodenumEfferent ductsEndometriumEpididymisEsophagusEyeFallopian tubeGallbladderHairHeart muscleHippocampusHypothalamusKidneyLactating breastLiverLungLymph nodeNasopharynxOral mucosaOvaryPancreasParathyroid glandPituitary glandPlacentaProstateRectumRetinaSalivary glandSeminal vesicleSkeletal muscleSkinSmall intestineSmooth muscleSoft tissueSole of footSpleenStomachSubstantia nigraTestisThymusThyroid glandTonsilUrinary bladderVagina Cell type Expression Antibody panel AnyCiliated cellsKidneyPancreasSalivary glandSertoli cellsSpermatidsSpermatocytesSpermatogonia Tissue Main location Patient ID Annotation Immunoglobulin genesIntracellular and membraneSecreted - unknown locationSecreted in brainSecreted in female reproductive systemSecreted in male reproductive systemSecreted in other tissuesSecreted to bloodSecreted to digestive systemSecreted to extracellular matrix Tissue AnyAdipose tissueAdrenal glandBlood vesselBone marrowBrainBreastCervixChoroid plexusEndometriumEpididymisEsophagusFallopian tubeGallbladderHeart muscleIntestineKidneyLiverLungLymphoid tissueOvaryPancreasParathyroid glandPituitary glandPlacentaProstateRetinaSalivary glandSeminal vesicleSkeletal muscleSkinSmooth muscleStomachTestisThyroid glandTongueUrinary bladderVagina Category Tissue enrichedGroup enrichedTissue enhancedLow tissue specificityNot detectedDetected in allDetected in manyDetected in someDetected in singleIs highest expressed Tau score 0.0-0.10.1-0.20.2-0.30.3-0.40.4-0.50.5-0.60.6-0.70.7-0.80.8-0.90.9-1.0 Cluster 14:Adipose tissue - Angiogenesis4:Adrenal gland - Steroid metabolism15:Bone marrow - Innate immune response44:Bone marrow - Nuclear processes73:Brain - Neuronal signaling78:Brain - Neuronal signaling10:Brain - Synaptic signal transduction65:Brain - Transcription36:Brain & Liver - Signaling46:Brain & retina - Neuronal signaling55:Breast - Lactation71:Cerebellum - Nervous system development27:Cerebellum - Synaptic function1:Choroid plexus - Transmembrane transport48:Ciliated tissues - Cilium organization56:Ciliated tissues - Cilium organization50:Epididymis - Male reproductive secretion22:Epididymis - Mixed function11:Esophagus - Basic cellular processes17:Intestine - Digestion77:Intestine - Digestion72:Kidney - Transmembrane transport26:Kidney & Intestine - Metabolism31:Liver - Metabolism & Coagulation45:Liver - Metabolism & Coagulation53:Liver - Plasma proteins28:Liver & Adrenal gland - Secretion16:Liver & Kidney - Metabolism13:Lung - Secretion34:Lymphoid tissue - Adaptive immune response51:Lymphoid tissue - Adaptive immune response18:Lymphoid tissue - Immune response66:Lymphoid tissue - Immune response59:Lymphoid tissue & Bone marrow - Cell proliferation29:Lymphoid tissue & Bone marrow - Innate immune response25:Non-specific - Basic cellular processes38:Non-specific - Basic cellular processes63:Non-specific - Basic cellular processes68:Non-specific - Basic cellular processes52:Non-specific - Cellular respiration76:Non-specific - Metabolism2:Non-specific - Mixed function35:Non-specific - Mixed function40:Non-specific - Mixed function70:Non-specific - Protein processing54:Non-specific - Ribosome74:Non-specific - Signal transduction24:Non-specific - Transcription49:Non-specific - Transcription61:Non-specific - Transcription64:Non-specific - Transcription3:Oligodendrocytes - Myelination75:Ovary - Mixed function8:Pancreas - Proteolysis69:Parathyroid gland - Mixed function20:Pituitary gland - Hormone signaling43:Placenta - Pregnancy hormone signaling42:Retina - Visual perception32:Retina & Lymphoid tissues - Signaling82:Salivary gland - Secretion62:Skeletal muscle - Muscle contraction19:Skeletal muscle - Striated muscle contraction30:Skeletal muscle - Striated muscle contraction9:Skin - Hair follicle development37:Skin - Keratinization58:Skin - Keratinization7:Small intestine - Absorption and Digestion12:Smooth muscle tissue - ECM organization5:Spleen - Immune response81:Squamous epithelium - Keratinization60:Stomach - Digestion41:Striated muscle - Muscle contraction21:Testis - Mixed function47:Testis - Mixed function67:Testis - Mixed function39:Testis - Nuclear processes6:Testis - Spermatogenesis23:Testis - Spermatogenesis57:Testis - Spermatogenesis79:Testis - Spermatogenesis80:Thymus - Adaptive immune response33:Thyroid gland - Tissue development Reliability EnhancedSupportedApprovedUncertain Brain region AnyAmygdalaBasal gangliaCerebellumCerebral cortexChoroid plexusHippocampal formationHypothalamusMedulla oblongataMidbrainPonsSpinal cordThalamusWhite matter Category Region enrichedGroup enrichedRegion enhancedLow region specificityNot detectedDetected in allDetected in manyDetected in someDetected in singleIs highest expressed Tau score 0.0-0.10.1-0.20.2-0.30.3-0.40.4-0.50.5-0.60.6-0.70.7-0.80.8-0.90.9-1.0 Brain region AnyAmygdalaBasal gangliaCerebellumCerebral cortexHippocampal formationHypothalamusMidbrainOlfactory bulbPons and medullaThalamusWhite matter Category Region enrichedGroup enrichedRegion enhancedLow region specificityNot detectedDetected in allDetected in manyDetected in someDetected in singleIs highest expressed Tau score 0.0-0.10.1-0.20.2-0.30.3-0.40.4-0.50.5-0.60.6-0.70.7-0.80.8-0.90.9-1.0 Brain region AnyAmygdalaBasal gangliaCerebellumCerebral cortexHippocampal formationHypothalamusMedulla oblongataMidbrainOlfactory bulbPonsSpinal cordThalamusWhite matter Category Region enrichedGroup enrichedRegion enhancedLow region specificityNot detectedDetected in allDetected in manyDetected in someDetected in singleIs highest expressed Tau score 0.0-0.10.1-0.20.2-0.30.3-0.40.4-0.50.5-0.60.6-0.70.7-0.80.8-0.90.9-1.0 Cluster 40:Astrocytes - Astrocyte-neuron interactions19:Astrocytes - Mixed function39:Astrocytes - Mixed function46:Brainstem - Mixed function10:Cerebellum - Nucleic acid binding32:Cerebral cortex - Mixed function3:Choroid plexus - Cilium17:Choroid plexus - Cilium42:Choroid plexus - Mitochondria23:Choroid plexus - Mixed function36:Choroid plexus - Mixed function47:Endothelial cells - Vasculature29:Forebrain - Mixed function43:Hindbrain - Mixed function49:Hindbrain - Mixed function56:Hypothalamus - Neuropeptide signaling8:Immune cells - Immune response54:Immune cells - T cell receptor20:Macrophages & Microglia - Immune response41:Monoamines - Neurotransmitter signalling1:Neurons - Mixed function24:Neurons - Mixed function33:Neurons - Mixed function37:Neurons - Mixed function51:Neurons - Mixed function53:Neurons - Mixed function2:Neurons - Nucleosome14:Neurons - Synaptic function52:Neurons & Synapses - Synaptic function35:Non-specific - DNA binding6:Non-specific - Immune response21:Non-specific - Metabolism5:Non-specific - Mixed function18:Non-specific - Mixed function22:Non-specific - Mixed function27:Non-specific - Mixed function34:Non-specific - Mixed function44:Non-specific - Mixed function45:Non-specific - Mixed function48:Non-specific - Mixed function4:Non-specific - mRNA splicing & Cell cycle50:Non-specific - Nucleic acid binding9:Non-specific - Receptor signaling7:Non-specific - Ribosome15:Non-specific - Transcription16:Non-specific - Transcription25:Non-specific - Transcription31:Non-specific - Transcription55:Non-specific - Transcription12:Non-specific - Vasculature13:Oligodendrocytes - Mixed function26:Oligodendrocytes - Mixed function28:Oligodendrocytes - Mixed function38:Sub-cortical - Mixed function30:White matter - Myelination11:White matter - Signal transduction Reliability SupportedApproved Tissue Adipose subcutaneousAdipose visceralAdrenal glandBreastColonHeart muscleKidneyLiverLungMinor Salivary GlandPancreasPituitary glandProstateSkeletal muscleSkinSpleenStomachTestisThyroid gland Cell type Enrichment Cell type AnyAdipocytesAdrenal cortex cellsAdrenal medulla cellsAlveolar cells type 1Alveolar cells type 2AstrocytesB-cellsBasal keratinocytesBasal prostatic cellsBergmann gliaBrain excitatory neuronsBrain inhibitory neuronsBreast hormone-responsive cellsBreast lactating cellsBreast myoepithelial cellsBreast secretory cellsCardiomyocytesCDCCholangiocytesChoroid plexus epithelial cellsColonocytesCone photoreceptor cellsConjunctival goblet cellsCorticotrophsCytotrophoblastsDecidual stromal cellsDifferentiating spermatogoniaDistal convoluted tubule cellsEarly primary spermatocytesEarly spermatidsEndometrial ciliated cellsEndometrial glandular cellsEndometrial luminal cellsEndometrial secretory cellsEndometrial stromal cellsEnteric stem cellsEnteric transient amplifying cellsEnterocytesEpendymal cellsEpicardial cellsEpididymal basal cellsEpididymal clear cellsEpididymal efferent duct absorptive cellsEpididymal efferent duct ciliated cellsEpididymal principal cellsErythrocyte progenitorsErythrocytesEsophageal apical cellsEsophageal basal cellsEsophageal suprabasal cellsExtravillous trophoblastsFallopian secretory cellsFallopian tube ciliated cellsFibro-adipogenic progenitorsFibroblastsFoveolar cellsGastric chief cellsGastric progenitor cellsGoblet cellsGonadotrophsGranulosa cellsHematopoietic stem cellsHepatic stellate cellsHepatocytesHofbauer cellsInnate lymphoid cellsKupffer cellsLacrimal acinar cellsLactotrophsLate primary spermatocytesLate spermatidsLeydig cellsLoop of henle epithelial cellsLymphatic endothelial cellsMacrophagesMast cellsMedullary thymic epithelial cellsMegakaryocyte progenitorsMegakaryocyte-Erythroid progenitorsMegakaryocytesMelanocytesMesothelial cellsMicrogliaMigrating cytotrophoblastsMonocyte progenitorsMonocytesMucous neck cellsMüller gliaMyonucleiMyosatellite cellsNeuroendocrine cellsNeutrophil progenitorsNeutrophilsNK-cellsOcular epithelial cellsOligodendrocyte progenitor cellsOligodendrocytesOocytesOther brain neuronsOvarian stromal cellsPancreatic acinar cellsPancreatic duct cellsPancreatic islet cellsPaneth cellsPapillary tip epithelial cellsParietal cellsPDCsPericytesPeritubular myoid cellsPituicytes/FSCsPituitary stem cellsPlasma cellsPlateletsPodocytesProstatic club cellsProstatic glandular cellsProstatic hillock cellsProximal tubule cellsRenal collecting duct intercalated cellsRenal collecting duct principal cellsRenal connecting tubule cellsRespiratory basal cellsRespiratory ciliated cellsRespiratory deuterosomal cellsRespiratory ionocytesRespiratory secretory cellsRetinal amacrine cellsRetinal bipolar cellsRetinal ganglion cellsRetinal horizontal cellsRetinal pigment epithelial cellsRod photoreceptor cellsSalivary acinar cellsSalivary basal cellsSalivary duct cellsSalivary ionocytesSalivary myoepithelial cellsSchwann cellsSertoli cellsSmooth muscle cellsSomatotrophsSubmucosal glandular cellsSuprabasal keratinocytesSyncytiotrophoblastsT-cellsThymic myoid cellsThymocytesThyrotrophsTransitional alveolar cellsTuft cellsUndifferentiated spermatogoniaUrothelial cellsVascular endothelial cellsVascular smooth muscle cells Category Cell type enrichedGroup enrichedCell type enhancedLow cell type specificityNot detectedDetected in allDetected in manyDetected in someDetected in singleIs highest expressed Tau score 0.0-0.10.1-0.20.2-0.30.3-0.40.4-0.50.5-0.60.6-0.70.7-0.80.8-0.90.9-1.0 Cell type group AnyAcinar cellsAdipocytesAdrenal endocrine cellsAlveolar cellsApical squamous epithelial cellsB-cellsBarrier epithelial cellsBasal cellsCiliated cellsDendritic cellsDuctal cellsEndothelial cellsEnterocytesEnteroendocrine cellsErythrocytesFibro-adipogenic progenitorsFibroblastsGastric glandular cellsGlandular cellsGlial cellsGoblet cellsHepatocytesInnate lymphoid cellsIonocytesLeydig cellsLuminal cellsMast cellsMegakaryocytesMononuclear phagocytesMural cellsMyocytesNeuronal cellsNeutrophilsNK-cellsOocytesPancreatic islet cellsPigment cellsPituitary endocrine cellsPlasma cellsPlateletsProliferating cellsRenal nephron cellsReproductive supporting cellsSecretory cellsSecretory gland supportSmooth muscle cellsSpermatogenic cell typesStellate cellsStem cellsStromal cellsSuprabasal cellsT-cellsTrophoblast cells Category Cell type enrichedGroup enrichedCell type enhancedLow cell type specificityNot detectedDetected in allDetected in manyDetected in someDetected in singleIs highest expressed Tau score 0.0-0.10.1-0.20.2-0.30.3-0.40.4-0.50.5-0.60.6-0.70.7-0.80.8-0.90.9-1.0 Cell type AnyAmygdala excitatoryAstrocyteBergmann gliaCentral nervous system macrophageCerebellar inhibitoryCGE interneuronChoroid plexus epithelial cellCommitted oligodendrocyte precursorDeep-layer corticothalamic and 6bDeep-layer intratelencephalicDeep-layer near-projectingEccentric medium spiny neuronEndothelial cellEpendymal cellFibroblastHippocampal CA1-3Hippocampal CA4Hippocampal dentate gyrusLAMP5-LHX6 and ChandelierLeukocyteLower rhombic lipMammillary bodyMedium spiny neuronMGE interneuronMidbrain-derived inhibitoryMiscellaneousOligodendrocyteOligodendrocyte precursor cellPericyteSplatterThalamic excitatoryUpper rhombic lipUpper-layer intratelencephalicVascular associated smooth muscle cell Category Cell type enrichedGroup enrichedCell type enhancedLow cell type specificityNot detectedDetected in allDetected in manyDetected in someDetected in singleIs highest expressed Tau score 0.0-0.10.1-0.20.2-0.30.3-0.40.4-0.50.5-0.60.6-0.70.7-0.80.8-0.90.9-1.0 Cell type AnyBasophilClassical monocyteEosinophilGdT-cellIntermediate monocyteMAIT T-cellMemory B-cellMemory CD4 T-cellMemory CD8 T-cellMyeloid DCNaive B-cellNaive CD4 T-cellNaive CD8 T-cellNeutrophilNK-cellNon-classical monocytePlasmacytoid DCT-regTotal PBMC Category Immune cell enrichedGroup enrichedImmune cell enhancedLow immune cell specificityNot detected in immune cellsNot detectedDetected in allDetected in manyDetected in someDetected in singleIs highest expressed Tau score 0.0-0.10.1-0.20.2-0.30.3-0.40.4-0.50.5-0.60.6-0.70.7-0.80.8-0.90.9-1.0 Cell lineage AnyB-cellsDendritic cellsGranulocytesMonocytesNK-cellsT-cells Category Lineage enrichedGroup enrichedLineage enhancedLow lineage specificityNot detectedDetected in allDetected in manyDetected in singleIs highest expressed Tau score 0.0-0.10.1-0.20.2-0.30.3-0.40.4-0.50.5-0.60.6-0.70.7-0.80.8-0.90.9-1.0 Cluster 17:B-cells - Immunoglobulins23:B-cells - Immunoglobulins34:B-cells - Unknown function46:Basophils - Proteolysis32:Basophils - Transcription41:Basophils - Unknown function2:Dendritic cells - Unknown function36:Eosinophils - Protein ubiquitination22:Eosinophils - Transcription19:Eosinophils - Unknown function45:Eosinophils - Unknown function40:Monocytes - Innate immune response26:Monocytes - Plasma membrane proteins38:Monocytes & Neutrophils - Degranulation37:Monocytes & Neutrophils - Innate immune response4:Neutrophils - Degranulation35:Neutrophils - Protein binding21:Neutrophils - Unknown function28:Neutrophils - Unknown function15:NK-cells - Unknown function33:Non-specific - ATP binding5:Non-specific - Cell proliferation16:Non-specific - Cell proliferation20:Non-specific - DNA binding30:Non-specific - DNA binding7:Non-specific - Innate immune response10:Non-specific - Membrane trafficking13:Non-specific - Mitochondria12:Non-specific - Mitochondrial translation3:Non-specific - Nuclear processes24:Non-specific - Transcription43:Non-specific - Transcription & Translation18:Non-specific - Translation14:Non-specific - Unknown function25:Non-specific - Unknown function29:Non-specific - Unknown function42:Non-specific - Vesicular transport44:Plasmacytoid DCs - Plasma membrane proteins8:Plasmacytoid DCs - Unknown function6:T-cells - T-cell receptor31:T-cells - T-cell receptor39:T-cells - T-cell receptor1:T-cells - Unknown function11:T-cells - Unknown function27:T-cells - Unknown function9:T-regs - Cell cycle regulation Cluster 89:Adipocytes - Lipid metabolism18:Adrenal cortex cells - Steroidogensis81:Alveolar cells - Lung function84:Apical squamous epithelium - Cornification49:Apical squamous epithelium - Epithelial barrier & keratinization28:Astrocytes - Homeostasis & neuron support87:B-cells - Adaptive immunity: Humoral response104:Brain endothelial cells - Blood brain barrier4:Breast lactating luminal cells - Lactation60:Cardiomyocytes - Cardiac muscle contraction & structure2:Cerebellar granular cells - Neuronal signaling19:Cerebellar purkinje cells - Neurotransmission & signaling101:Choroid plexus epithelial cells - Ion transport34:Ciliated cells - Cilia assembly & function107:Ciliated cells - Cilia assembly & function45:Colonocytes & Enterocytes - Gastrointestinal absorption & barrier63:Cytotrophoblasts - Basic cellular functions82:Dendritic cells - Antigen presentation3:Early primary spermatocytes - Early meiosis42:Early spermatids - Spermiogenesis: Acrosomal phase33:Early spermatids - Spermiogenesis: Cap phase23:Elongating spermatids - Sperm cell metabolism & fertilization90:Elongating spermatids - Spermiogenesis: Elongation12:Endothelial cells - Angiogenesis & vascular homeostasis32:Endothelial cells - Angiogenesis & vascular immunity1:Enterocytes - Absorption and Digestion96:Enteroendocrine cells - Neuropeptide signaling83:Epicardial mesothelial cells - Basic cellular functions10:Epididymal principal cells - Sperm maturation microenvironment30:Epididymal principal cells - Sperm storage microenvironment66:Erythroid cells - Erythroid differentiation and maturation21:Extravillous trophoblasts - Placental invasion & endocrine regulatio108:Fibroblasts - ECM organization68:Foveolar cells - Mucosal defense52:Glandular & Luminal cells - Estrogen-regulated epithelial secretion94:Gonadal somatic cells - Mixed function93:Hepatocytes - Bile production & excretion25:Hepatocytes - Plasma protein synthesis & secretion54:Intestinal epithelial cells - Intestinal epi homeostasis & respiration70:Intestinal goblet cells - Mucin production26:Keratinocytes - Keratinization53:Late primary spermatocytes - Meiotic division & transition77:Late primary spermatocytes - Spermiogenesis: Golgi Phase56:Late spermatids - Spermiogenesis: Maturation73:Late spermatids - Spermiogenesis: Maturation72:Macrophages - Phagocytosis & lysosomal degradation58:Mast cells - Allergic inflammatory responses74:Microglia - Neuroimmunity & neuroinflammation40:Monocytes & Neutrophils - Inflammatory signaling11:Muller glia cells - Retinal homeostasis110:Mural cells - ECM organization55:Myocytes - Oxidative muscle function109:Neurons - Neuronal signaling98:Neurons - Neurotransmission & signaling35:Neurons - Synaptic function & neurogenesis37:Neutrophil progenitors - Granulopoiesis31:Neutrophils - Chemotaxis & Apoptosis29:Neutrophils - Innate immune cellular maintenance24:Neutrophils - Innate immunity signal integration48:Neutrophils - Phagocytosis & degranulation92:NK-cells & T-cells - Adaptive immunity: Cytotoxicity22:Non-specific - Basic cellular functions103:Non-specific - Basic cellular processes71:Non-specific - Cardiac endocrine signaling & maintenanc65:Non-specific - Cell growth & division27:Non-specific - Cell proliferation97:Non-specific - Cellular respiration75:Non-specific - Chaperones and protein folding102:Non-specific - Mixed function105:Non-specific - Mixed function15:Non-specific - Protein processing17:Non-specific - RNA processing8:Non-specific - Secretory pathway7:Non-specific - Transcription20:Non-specific - Transcription regulation14:Oligodendrocyte progenitor cells - Development & myelination80:Oligodendrocytes - Myelination41:Oocytes - Oogenesis5:Pancreatic acinar cells - Pancreatic exocrine secretion76:Pancreatic endocrine cells - Endocrine signaling79:Photoreceptor cells - Phototransduction91:Pituicytes/FSC - Homeostasis & neuron support59:Pituitary endocrine cells - Neuroendocrine signaling78:Plasma cells - Antibody production & ER-stress response44:Plasma cells - Antibody production & secretion67:Plasma cells - Plasma cell differentiation6:Plasmacytoid dendritic cells - Viral sensing & interferon response47:Platelets - Hemostasis57:Podocytes - Glomerular filtration16:Prostatic glandular cells - Androgen response & seminal fluid88:Proximal tubular cells - Transmembrane transport64:Renal epithelial cells - Ion transport & homeostasis50:Renal epithelial cells - Ion transport and pH regulation86:Retinal bipolar cells - Synaptic signal transduction99:Retinal pigment epithelial cells - Retinol metabolism61:Schwann cells & Melanocytes - Mixed function38:Secretory epithelial cells - Exocrine secretion51:Secretory epithelial cells - Mixed function43:Sertoli cells - Spermatogenesis microenvironment36:Skeletal myocytes - Muscle excitation & contraction46:Skeletal myocytes - Muscle structure & formation62:Smooth muscle cells - Muscle contraction106:Spermatogonia - Spermatogonial differentiation85:Squamous epithelial cells - Keratinization100:Stratified epithelial cells - Barrier functions39:Syncytiotrophoblasts - Placental homeostasis & endocrine signal13:Syncytiotrophoblasts - Placental remodeling & endocrine func.9:T-cells - Adaptive immunity: Regulation95:Tuft cells - Chemosensory signaling69:Urothelial cells - Basic cellular functions Location AcrosomeActin filamentsAggresomeAnnulusBasal bodyCalyxCell JunctionsCentriolar satelliteCentrosomeCleavage furrowConnecting pieceCytokinetic bridgeCytoplasmic bodiesCytosolEnd pieceEndoplasmic reticulumEndosomesEquatorial segmentFlagellar centrioleFocal adhesion sitesGolgi apparatusIntermediate filamentsKinetochoreLipid dropletsLysosomesMicrotubule endsMicrotubulesMid pieceMidbodyMidbody ringMitochondriaMitotic chromosomeMitotic spindleNuclear bodiesNuclear membraneNuclear specklesNucleoliNucleoli fibrillar centerNucleoli rimNucleoplasmPerinuclear thecaPeroxisomesPlasma membranePrimary ciliumPrimary cilium tipPrimary cilium transition zonePrincipal pieceRods & RingsVesicles Searches EnhancedSupportedApprovedUncertainSingle cell variationCCD protein mitotic structureCCD protein interphaseCell cycle dependent proteinCell cycle independent proteinCell cycle dependent transcriptCell cycle independent transcriptMultilocalizingLocalizing 1Localizing 2Localizing 3Localizing 4Localizing 5Localizing 6Main locationAdditional location Location AnyAcrosomeActin filamentsAggresomeAnnulusBasal bodyCalyxCell JunctionsCentriolar satelliteCentrosomeCleavage furrowConnecting pieceCytokinetic bridgeCytoplasmic bodiesCytosolEnd pieceEndoplasmic reticulumEndosomesEquatorial segmentFlagellar centrioleFocal adhesion sitesGolgi apparatusIntermediate filamentsKinetochoreLipid dropletsLysosomesMicrotubule endsMicrotubulesMid pieceMidbodyMidbody ringMitochondriaMitotic chromosomeMitotic spindleNuclear bodiesNuclear membraneNuclear specklesNucleoliNucleoli fibrillar centerNucleoli rimNucleoplasmPerinuclear thecaPeroxisomesPlasma membranePrimary ciliumPrimary cilium tipPrimary cilium transition zonePrincipal pieceRods & RingsVesicles Cell line AnyA-431A-549AF22ASC52teloBJ [Human fibroblast]CACO-2EFO-21GAMGHaCaTHAP1HBEC3-KTHDLM-2HEK293HELHeLaHep-G2HTCEpiHTERT-RPE1HTERT-RPE1 (serum starved)HUVEC/TERT2JURKATK-562KOLF2.1JLHCN-M2MCF-7NB4OE19PC-3PODO/SVTERT152PODO/TERT256REHRh30RPTEC/TERT1RT-4SH-SY5YSiHaSK-MEL-30SpermSuSaTHP-1U-251MGU2OS Class Predicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins Type ProteinRna Phase G1SG2 Reliability EnhancedSupportedApprovedUncertain Cancer Bladder Urothelial CarcinomaBreast Invasive CarcinomaCervical Squamous Cell Carcinoma and Endocervical AdenocarcinomaColon AdenocarcinomaGlioblastoma MultiformeHead and Neck Squamous Cell CarcinomaKidney ChromophobeKidney Renal Clear Cell CarcinomaKidney Renal Papillary Cell CarcinomaLiver Hepatocellular CarcinomaLung AdenocarcinomaLung Squamous Cell CarcinomaOvary Serous CystadenocarcinomaPancreatic AdenocarcinomaProstate AdenocarcinomaRectum AdenocarcinomaSkin Cutaneous MelanomaStomach AdenocarcinomaTesticular Germ Cell TumorThyroid CarcinomaUterine Corpus Endometrial Carcinoma Prognosis Favorable - potential prognosticFavorable - validated prognosticUnfavorable - potential prognosticUnfavorable - validated prognostic Cancer AnyBladder Urothelial CarcinomaBreast Invasive CarcinomaCervical Squamous Cell Carcinoma and Endocervical AdenocarcinomaColon AdenocarcinomaGlioblastoma MultiformeHead and Neck Squamous Cell CarcinomaKidney ChromophobeKidney Renal Clear Cell CarcinomaKidney Renal Papillary Cell CarcinomaLiver Hepatocellular CarcinomaLung AdenocarcinomaLung Squamous Cell CarcinomaOvary Serous CystadenocarcinomaPancreatic AdenocarcinomaProstate AdenocarcinomaRectum AdenocarcinomaSkin Cutaneous MelanomaStomach AdenocarcinomaTesticular Germ Cell TumorThyroid CarcinomaUterine Corpus Endometrial Carcinoma Category Cancer enrichedGroup enrichedCancer enhancedLow cancer specificityNot detectedDetected in allDetected in manyDetected in someDetected in singleIs highest expressed Cancer AnyAdrenocortical cancerBile duct cancerBladder cancerBone cancerBrain cancerBreast cancerCervical cancerColorectal cancerEsophageal cancerGallbladder cancerGastric cancerHead and neck cancerKidney cancerLeukemiaLiver cancerLung cancerLymphomaMyelomaNeuroblastomaNon-cancerousOvarian cancerPancreatic cancerProstate cancerRhabdoidSarcomaSkin cancerTestis cancerThyroid cancerUncategorizedUterine cancer Category Cancer enrichedGroup enrichedCancer enhancedLow cancer specificityNot detectedDetected in allDetected in manyDetected in someDetected in singleIs highest expressed Tau score 0.0-0.10.1-0.20.2-0.30.3-0.40.4-0.50.5-0.60.6-0.70.7-0.80.8-0.90.9-1.0 Cluster 48:Adipocytes & Endothelial cells - Angiogenesis61:BICR 18 - Protein kinases12:Bone cancer - Neuronal signaling27:Breast cancer - Unknown function10:Ciliated cells - Ion channel activity44:Connective tissue cells - ECM organization64:Connective tissue cells - ECM organization70:DU4475 - Unknown function49:HMC-1 - Innate immune response15:Kidney cancer - Membrane components47:Leukemia - Hemostasis6:Leukemia - Signal transduction59:Leukemia - T-cell receptor7:Liver cancer - Metabolism18:Liver cancer - Metabolism21:Lymphoma - Adaptive immune response46:Lymphoma - Humoral immune response55:Lymphoma - Immune response71:Lymphoma - Inflammatory response50:Lymphoma - Unknown function2:Mucus-secreting cells - Unknown function14:Myeloid leukemia - Innate immune response20:Myeloma - Immune response51:Myeloma - Immunoglobulins17:Neuroblastoma - Neuronal signaling11:Neuronal - Sensory perception72:Neuronal - Signal transduction1:Neuronal - Visual perception31:Non-specific - Antiviral immune response8:Non-specific - Basic cellular processes43:Non-specific - Basic cellular processes68:Non-specific - Cell cycle regulation32:Non-specific - Cell proliferation30:Non-specific - Gene expression regulation52:Non-specific - Mitochondria66:Non-specific - Mitochondria26:Non-specific - Mitochondria & RNA binding13:Non-specific - Mixed function36:Non-specific - mRNA processing37:Non-specific - mRNA processing22:Non-specific - mRNA splicing & Cell cycle28:Non-specific - Nuclear processes45:Non-specific - Nuclear processes58:Non-specific - Nuclear processes41:Non-specific - Nucleosome assembly62:Non-specific - Plasma proteins63:Non-specific - Protein processing25:Non-specific - Ribosome56:Non-specific - Sensory perception4:Non-specific - Transcription23:Non-specific - Transcription38:Non-specific - Transcription39:Non-specific - Transcription54:Non-specific - Transcription19:Non-specific - Unknown function24:Non-specific - Unknown function29:Non-specific - Unknown function40:Non-specific - Unknown function42:Non-specific - Unknown function65:Non-specific - Unknown function67:Non-specific - Unknown function60:Prostate cancer - Unknown function3:Rhabdoid - Membrane components5:Rhabdoid - Unknown function35:RS4;11 - Unknown function33:Sarcoma - Muscle contraction69:Skin cancer - ECM organization9:Skin cancer - Melanin biosynthesis53:Squamous epithelial cells - Keratinization57:Stomach & Colon cancer - Digestion34:Testis cancer - Unknown function16:Thyroid cancer - Neuronal signaling Variants Alphamissense populationAlphamissense clinicalExperimental PopulationExperimental clinical Interacting gene (ensg_id) Type ConsensusIntActBioGridOpenCellBioPlex Number of interactions 123456-1011-2021-3031-4041-5051-7576-100101-200>200 Pathway Acyl-CoA hydrolysisAcylglycerides metabolismAlanine; aspartate and glutamate metabolismAmino sugar and nucleotide sugar metabolismAminoacyl-tRNA biosynthesisAndrogen metabolismArachidonic acid metabolismArginine and proline metabolismAscorbate and aldarate metabolismBeta oxidation of branched-chain fatty acids (mitochondrial)Beta oxidation of di-unsaturated fatty acids (n-6) (mitochondrial)Beta oxidation of di-unsaturated fatty acids (n-6) (peroxisomal)Beta oxidation of even-chain fatty acids (mitochondrial)Beta oxidation of even-chain fatty acids (peroxisomal)Beta oxidation of odd-chain fatty acids (mitochondrial)Beta oxidation of phytanic acid (peroxisomal)Beta oxidation of poly-unsaturated fatty acids (mitochondrial)Beta oxidation of unsaturated fatty acids (n-7) (mitochondrial)Beta oxidation of unsaturated fatty acids (n-7) (peroxisomal)Beta oxidation of unsaturated fatty acids (n-9) (mitochondrial)Beta oxidation of unsaturated fatty acids (n-9) (peroxisomal)Beta-alanine metabolismBile acid biosynthesisBile acid recyclingBiopterin metabolismBiotin metabolismBlood group biosynthesisButanoate metabolismC5-branched dibasic acid metabolismCarnitine shuttle (cytosolic)Carnitine shuttle (endoplasmic reticular)Carnitine shuttle (mitochondrial)Carnitine shuttle (peroxisomal)Cholesterol biosynthesis 1 (Bloch pathway)Cholesterol biosynthesis 2Cholesterol biosynthesis 3 (Kandustch-Russell pathway)Cholesterol metabolismChondroitin / heparan sulfate biosynthesisChondroitin sulfate degradationCysteine and methionine metabolismDrug metabolismEicosanoid metabolismEstrogen metabolismEther lipid metabolismFatty acid activation (cytosolic)Fatty acid activation (endoplasmic reticular)Fatty acid biosynthesisFatty acid biosynthesis (even-chain)Fatty acid biosynthesis (odd-chain)Fatty acid biosynthesis (unsaturated)Fatty acid degradationFatty acid desaturation (even-chain)Fatty acid desaturation (odd-chain)Fatty acid elongation (even-chain)Fatty acid elongation (odd-chain)Fatty acid metabolismFatty acid oxidationFolate metabolismFormation and hydrolysis of cholesterol estersFructose and mannose metabolismGalactose metabolismGlucocorticoid biosynthesisGlutathione metabolismGlycerolipid metabolismGlycerophospholipid metabolismGlycine; serine and threonine metabolismGlycolysis / GluconeogenesisGlycosphingolipid biosynthesis-ganglio seriesGlycosphingolipid biosynthesis-globo seriesGlycosphingolipid biosynthesis-lacto and neolacto seriesGlycosphingolipid metabolismGlycosylphosphatidylinositol (GPI)-anchor biosynthesisGlyoxylate and dicarboxylate metabolismHeme degradationHeparan sulfate degradationHistidine metabolismInositol phosphate metabolismInsect hormone biosynthesisIsolatedKeratan sulfate biosynthesisKeratan sulfate degradationLeukotriene metabolismLinoleate metabolismLipoic acid metabolismLysine metabolismMetabolism of other amino acidsMiscellaneousN-glycan metabolismNicotinate and nicotinamide metabolismNucleotide metabolismO-glycan metabolismOctane oxidationOmega-3 fatty acid metabolismOmega-6 fatty acid metabolismOxidative phosphorylationPantothenate and CoA metabolismPentose and glucuronate interconversionsPentose phosphate pathwayPhenylalanine metabolismPhenylalanine; tyrosine and tryptophan biosynthesisPhosphatidylinositol phosphate metabolismPool reactionsPorphyrin metabolismPropanoate metabolismProstaglandin biosynthesisProtein assemblyProtein degradationProtein modificationPurine metabolismPyrimidine metabolismPyruvate metabolismRetinol metabolismRiboflavin metabolismROS detoxificationSerotonin and melatonin biosynthesisSphingolipid metabolismStarch and sucrose metabolismSteroid metabolismSulfur metabolismTerpenoid backbone biosynthesisThiamine metabolismToluene degradationTransport reactionsTricarboxylic acid cycle and glyoxylate/dicarboxylate metabolismTryptophan metabolismTyrosine metabolismUbiquinone and other terpenoid-quinone biosynthesisUbiquinone synthesisValine; leucine; and isoleucine metabolismVitamin A metabolismVitamin B12 metabolismVitamin B2 metabolismVitamin B6 metabolismVitamin C metabolismVitamin D metabolismVitamin E metabolismXenobiotics metabolism ipTM 0-0.20.2-0.40.4-0.60.6-0.80.8-1 Category Evidence at protein levelEvidence at transcript levelNo human protein/transcript evidence Category Evidence at protein levelEvidence at transcript levelNo human protein/transcript evidence Category Evidence at protein levelEvidence at transcript levelNo human protein/transcript evidence Category Evidence at protein levelEvidence at transcript levelNo human protein/transcript evidence Validation SupportedApprovedUncertain Validation Enhanced - CaptureEnhanced - GeneticEnhanced - IndependentEnhanced - OrthogonalEnhanced - RecombinantSupportedApprovedUncertain Validation Enhanced - IndependentEnhanced - OrthogonalSupportedApprovedUncertain Validation Enhanced - GeneticEnhanced - IndependentEnhanced - RecombinantSupportedApprovedUncertain Antibodies YesNo Data type Tissue - ImmunohistochemistryTissue - GTEx transcriptomicsTissue - FANTOM transcriptomicsTissue - Expression clusteringBrainBrain - Expression clusteringSingle cell - Expression clusteringImmune cell - Expression clusteringSubcellularCancer - ImmunohistochemistryCancer - Mass spectrometryBlood - conc. immunoassayBlood - conc. mass spectrometryBlood - Olink HTBlood - Olink 1536Blood - SomaScanBlood - ProteomEdgeBlood - Targeted proteomicsCell line - Mass spectrometryCell line - Expression clusteringStructureInteractionMetabolic Column GenePositionTissue specific scorePrognosticReliability (IF)Reliability (IH) Add Cancel

• SUMMARY

• TISSUE

• BRAIN

• SINGLE CELL

• SUBCELL

• CANCER

• BLOOD

• CELL LINE

• STRUCTURE

• INTERACTION

CH25H

PROTEIN SUMMARY GENE INFORMATION RNA DATA

Hippocampal formation Amygdala Basal ganglia Midbrain Spinal cord Cerebral cortex Cerebellum Hypothalamus Choroid plexus Retina Thyroid gland Parathyroid gland Adrenal gland Pituitary gland Lung Salivary gland Esophagus Tongue Stomach Duodenum Colon Rectum Small intestine Liver Gallbladder Pancreas Kidney Urinary bladder Testis Epididymis Prostate Seminal vesicle Vagina Breast Cervix Endometrium Fallopian tube Ovary Placenta Blood vessel Heart muscle Skeletal muscle Smooth muscle Adipose tissue Skin Bone marrow Spleen Tonsil Lymph node Appendix Thymus CH25H INFORMATION Proteini Full gene name according to HGNC. Cholesterol 25-hydroxylase Gene namei Official gene symbol, which is typically a short form of the gene name, according to HGNC. CH25H Protein classi Assigned HPA protein class(es) for the encoded protein(s). Read more Enzymes Metabolic proteins Protein evidence Evidence at protein level (all genes) Number of transcriptsi Number of protein-coding transcripts from the gene as defined by Ensembl. 1 Protein interactions Interacting with 2 proteins PROTEIN EXPRESSION AND LOCALIZATION Tissue profilei A summary of the overall protein expression profile across the analyzed normal tissues based on knowledge-based annotation, presented in the Tissue resource. "Estimation of protein expression could not be performed. View primary data." is shown for genes where available RNA-seq and gene/protein characterization data in combination with immunohistochemistry data has been evaluated as not sufficient to yield a reliable estimation of the protein expression profile. Not available Subcellular locationi Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas. Not available Predicted locationi All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Membrane TISSUE RNA EXPRESSION Tissue specificityi The RNA specificity category is based on normalized mRNA expression levels in the consensus dataset, calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. Tissue enhanced (Lymphoid tissue) Tissue expression clusteri The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Bone marrow - Nuclear processes (mainly) Brain specificityi The regional specificity category is based on mRNA expression levels in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. All brain expression profiles are based on data from HPA. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category Low human brain regional specificity Brain expression clusteri The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Non-specific - Mixed function (mainly) CELL TYPE RNA EXPRESSION Single cell type specificityi The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Cell type enhanced (Vascular smooth muscle cells, Pericytes, Microglia, Breast lactating cells, Epididymal principal cells, Fibroblasts, Ocular epithelial cells, Esophageal basal cells, Smooth muscle cells, Macrophages) Single cell typeexpression clusteri The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Non-specific - Basic cellular processes (mainly) Tissue cell type classificationi Genes can have enriched specificity in different cell types in one or several tissues, or be enriched in a core cell type that appears in many different tissues. No predicted cell type specificity Immune cell specificityi The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Not detected in immune cells Immune cellexpression clusteri The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Not detected - no cluster assigned CANCER & CELL LINES Prognostic summary CH25H is a prognostic marker in Liver hepatocellular carcinoma, Lung squamous cell carcinoma, Ovary serous cystadenocarcinoma Cancer specificityi Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected. Low cancer specificity Cell lineexpression clusteri The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Connective tissue cells - ECM organization (mainly) Cell line specificityi RNA specificity category based on RNA sequencing data from cancer cell lines in the Human Protein Atlas grouped according to type of cancer. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Group enriched (Brain cancer, Thyroid cancer, Uterine cancer) PROTEINS IN BLOOD Detected in blood byimmunoassayi The blood-based immunoassay category applies to actively secreted proteins and is based on plasma or serum protein concentrations established with enzyme-linked immunosorbent assays, compiled from a literature search. The categories include: detected and not detected, where detection refers to a concentration found in the literature search. No (not applicable) Detected in blood bymass spectrometryi Detection or not of the gene in blood, based on spectral count estimations from a publicly available mass spectrometry-based plasma proteomics dataset obtained from the PeptideAtlas. Read more No Proximity extension assayi Indicates whether the protein has been measured (Data available) or not (Not available) using the Olink Explore HT proximity extension assay platform. Read more Not available SomaScani Indicates whether the protein has been measured (Data available) or not (Not available) using the SomaScan 11K platform. Read more Not available PROTEIN FUNCTION Protein function (UniProt)i Useful information about the protein provided by UniProt. Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes 1. Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells (By similarity). May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing 2. As an interferon-stimulated gene, has broad antiviral activities against a wide range of enveloped viruses, such as vesicular stomatitis virus (VSV) and SARS coronavirus-2 (SARS-CoV-2). Its product, 25-hydroxycholesterol, activates the ER-localized enzyme ACAT to induce internalization of accessible cholesterol on the plasma membrane and restricts SARS-CoV-2 S protein-mediated fusion which inhibits virus replication 3, 4. In testis, production of 25-hydroxycholesterol by macrophages plays a role in Leydig cell differentiation (By similarity). Required to restrain inflammation in macrophages: production of 25-hydroxycholesterol protects macrophages from cholesterol overload, thereby preventing mitochondrial DNA release and subsequent activation of the AIM2 inflammasome (By similarity).... show less Molecular function (UniProt)i Keywords assigned by UniProt to proteins due to their particular molecular function. Monooxygenase, Oxidoreductase Biological process (UniProt)i Keywords assigned by UniProt to proteins because they are involved in a particular biological process. Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism Ligand (UniProt)i Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule. Iron, Metal-binding Gene summary (Entrez)i Useful information about the gene from Entrez This is an intronless gene that is involved in cholesterol and lipid metabolism. The encoded protein is a membrane protein and contains clusters of histidine residues essential for catalytic activity. Unlike most other sterol hydroxylases, this enzyme is a member of a small family of enzymes that utilize diiron cofactors to catalyze the hydroxylation of hydrophobic substrates. [provided by RefSeq, Jul 2008]... show less

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